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Tandospirone citrate

CAS No.: 112457-95-1

Chemical Name:: Tandospirone citrate

Synonyms: andospironecitrate;SM 3997;Methanospirone;SM-3997 citrate;tandospirone citrate;Tandopsirone citrate;Tandospirone-d8 Citrate;Tandospirone citrate (SM 3997);2-(Dicyclohexylphosphanyl)-1-(2-methoxy-6-(triethylsilyl)phenyl)-1H-pyrrole;(3aR,4R,7S,7aS)-2-(4-chlorobutyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

CBNumber:: CB71270043

Molecular Formula:: C21H29N5O2.C6H8O7

Molecular Weight:: 575.615

MOL File:: 112457-95-1.mol

Modify Date:: 2024/7/2 8:55:15

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Tandospirone citrate Properties

Melting point	169.5-170°
storage temp.	Inert atmosphere,Store in freezer, under -20°C
form	Solid
color	White to off-white
Water Solubility	Water: 10.4 mg/mL (18.07 mM)
InChIKey	DMLGUJHNIWGCKM-DPFKZJTMNA-N
SMILES	[C@@]12(C(=O)N(CCCCN3CCN(C4=NC=CC=N4)CC3)C(=O)[C@]1([C@@]1(CC[C@]2(C1)[H])[H])[H])[H].C(O)(C(=O)O)(CC(=O)O)CC(=O)O \|&1:0,22,23,26,r\|

Tandospirone citrate Chemical Properties,Uses,Production

Uses

Tandospirone citrate is a potent 5-HT1A partial agonist with a Ki value of 27 nM. Tandospirone citrate is approximately two to three orders of magnitude less potent at 5-HT2, 5-HT1C, alpha 1-adrenergic, alpha 2-adrenergic, and dopamine D1 and D2 receptors (Ki values ranging from 1300 to 41000 nM).
Anti-anxiety agent.

Pharmacology

Tandospirone citrate is a partial agonist of the 5-hydroxytryptamine type 1A (5-HT1A) receptor,which selectively binds to the 5-HT1A receptor in the brain. The anti-anxiety effect is exerted by inhibiting the activities of the 5-HT1A system via selectively stimulating the 5-HT1A receptor widely distributed in these sites.

Side effects

The most common adverse reactions to Tandospirone citrate include drowsiness, dizziness, headache, nausea, malaise, rash, urticaria and pruritus. In addition, there are some symptoms that require special attention, such as those related to hepatic insufficiency and jaundice: general malaise, loss of appetite, yellowing of the skin and whites of the eyes. Excitement, sweating and trembling associated with serotonin syndrome. Fever, impaired consciousness, sweating associated with malignant syndrome. These symptoms are rarely considered initial symptoms of the indicated adverse reaction. However, if you experience discomfort, contact your doctor immediately.

Tandospirone citrate Preparation Products And Raw materials

Raw materials

Tandospirone Citric acid

Preparation Products

Tandospirone citrate Suppliers

Global( 117)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Chengdu Aupone Pharmaceutical Co.Ltd.	+86-28-+86-28-87843998-6060-6060 +8618631098571	China	54	58	Inquiry
Biopole Pharmatech Co., Ltd.	+8615151475053	China	37	58	Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	10991	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29899	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	China	7255	58	Inquiry
changzhou huayang technology co., ltd	+8615250961469	China	9740	58	Inquiry

Supplier	Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
Chengdu Aupone Pharmaceutical Co.Ltd.	58
Biopole Pharmatech Co., Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Shanghai UCHEM Inc.	58
changzhou huayang technology co., ltd	58

Tandospirone citrate Spectrum

Tandospirone citrate(112457-95-1)¹HNMR

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4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aa,4b,7b,7aa)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) 4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (9CI) SM 3997 tandospirone citrate (3aα,4β,7β,7aα)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione·citric acid Methanospirone Tandopsirone citrate 3aalpha,4alpha,5,6,7alpha,7aalpha-Hexahydro-2-[4- [4-(2-pyriMidinyl)-1-piperazinyl]butyl]-4,7-Methano-1H-isoindole-1,3(2H)-dione dihydrogen citrate (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione 2-hydroxy-1,2,3-propanetricarboxylate (1:1) SM-3997 citrate rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate Tandospirone citrate (SM 3997) Tandospirone-d8 Citrate andospironecitrate SM3997,SM-3997,Tandospirone,Tandospirone citrate,Inhibitor,Serotonin Receptor,SM 3997,5-hydroxytryptamine Receptor,inhibit,5-HT Receptor 2-(Dicyclohexylphosphanyl)-1-(2-methoxy-6-(triethylsilyl)phenyl)-1H-pyrrole 4-((3aR,4S,7R,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl)butyl 4-(pyrimidin-2-yl)piperazine-1-carboxylate (1S,2R,3S,4R)-3-((4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)carbamoyl)bicyclo[2.2.1]heptane-2-carboxylic acid (3aR,3a'R,4S,4'S,7R,7aS,7'R,7a'S)-2,2'-(piperazine-1,4-diylbis(butane-4,1-diyl))bis(hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione) (3aR,4R,7S,7aS)-2-(4-chlorobutyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione (3aR,4S,7R,7aS)-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate 112457-95-1 C21H29N5O2C6H8O7 112457-95-1 API