SB 223412
- CAS No.
- 174636-32-9
- Chemical Name:
- SB 223412
- Synonyms
- CS-1123;SB 223412;Talnetant (SB 223412);SB-223412; SB223412; SB 223412;3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;(S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide;(S)-3-Hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide;3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide;(-)-3-Hydroxy-2-phenyl-N-[1(S)-phenylpropyl]quinoline-4-carboxamide
- CBNumber:
- CB71333041
- Molecular Formula:
- C25H22N2O2
- Molecular Weight:
- 382.45
- MOL File:
- 174636-32-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:03:01
| Melting point | 125.1-126.2℃ |
|---|---|
| Boiling point | 580.4±50.0 °C(Predicted) |
| Density | 1.212±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: soluble25mg/mL, clear |
| form | powder |
| pka | 6.70±0.50(Predicted) |
| color | white to beige |
| optical activity | [α]/D -25 to -31°, c = 0.5 in methanol |
SB 223412 price More Price(2)
SB 223412 Chemical Properties,Uses,Production
Description
Talnetant is an antagonist of the neurokinin-3 (NK3) receptor (Ki = 1 nM). It is selective for NK3 over NK1 and NK2 receptors (Kis = 144 and >100,000 nM, respectively, in CHO cells expressing recombinant human receptors). Talnetant inhibits calcium mobilization induced by neurokinin B in HEK293 cells expressing human NK3 receptors (IC50 = 16.6 nM). It inhibits contractions induced by the NK3 receptor agonist senktide in isolated rabbit iris sphincter muscle (pD2 = 9.1). Talnetant (5-20 mg/kg) reduces senktide-induced head shakes and tail whips in mice. It also inhibits senktide-induced wet-dog shakes, increases extracellular dopamine and norepinephrine in the medial prefrontal cortex, and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs.
SB 223412 Preparation Products And Raw materials
SB 223412 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | CHINA | 9427 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | China | 42057 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |