SB 223412
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- ₹14440.55 - ₹58151.9
- Product name: SB 223412
- CAS: 174636-32-9
- MF: C25H22N2O2
- MW: 382.45
- EINECS:
- MDL Number:MFCD00944075
- Synonyms:SB 223412;3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;(-)-(S)-N-(alpha-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxaMide;TALNETANT//SB223412//3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxaMide;(-)-3-Hydroxy-2-phenyl-N-[1(S)-phenylpropyl]quinoline-4-carboxamide;(S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide;3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide;3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1165
- Product descriptionTalnetant ≥98% (HPLC)
- Packaging5MG
- Price₹14440.55
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1165
- Product descriptionTalnetant ≥98% (HPLC)
- Packaging25MG
- Price₹58151.9
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1165 | Talnetant ≥98% (HPLC) | 5MG | ₹14440.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1165 | Talnetant ≥98% (HPLC) | 25MG | ₹58151.9 | 2022-06-14 | Buy |
Properties
Melting point :125.1-126.2℃
Boiling point :580.4±50.0 °C(Predicted)
Density :1.212±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble25mg/mL, clear
form :powder
pka :6.70±0.50(Predicted)
color :white to beige
optical activity :[α]/D -25 to -31°, c = 0.5 in methanol
Boiling point :580.4±50.0 °C(Predicted)
Density :1.212±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble25mg/mL, clear
form :powder
pka :6.70±0.50(Predicted)
color :white to beige
optical activity :[α]/D -25 to -31°, c = 0.5 in methanol
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Talnetant is an antagonist of the neurokinin-3 (NK3) receptor (Ki = 1 nM). It is selective for NK3 over NK1 and NK2 receptors (Kis = 144 and >100,000 nM, respectively, in CHO cells expressing recombinant human receptors). Talnetant inhibits calcium mobilization induced by neurokinin B in HEK293 cells expressing human NK3 receptors (IC50 = 16.6 nM). It inhibits contractions induced by the NK3 receptor agonist senktide in isolated rabbit iris sphincter muscle (pD2 = 9.1). Talnetant (5-20 mg/kg) reduces senktide-induced head shakes and tail whips in mice. It also inhibits senktide-induced wet-dog shakes, increases extracellular dopamine and norepinephrine in the medial prefrontal cortex, and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs.Suppliers and manufacturers
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