AMILORIDE
- CAS No.
- 2609-46-3
- Chemical Name:
- AMILORIDE
- Synonyms
- MK-870;AMILORIDE;AMILORIDE Impurity;N-amidino-3,5-diamino-6-chloropyrazine-2-carboxamide;3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide;3,5-Diamino-6-chloro-N-(diaminomethylene)pyrazinecarboxamide;3,5-Diamino-6-chloro-N-(aminoiminomethyl)-2-pyrazinecarboxamide;2-Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-
- CBNumber:
- CB7146512
- Molecular Formula:
- C6H8ClN7O
- Molecular Weight:
- 229.63
- MOL File:
- 2609-46-3.mol
- Modify Date:
- 2024/7/2 8:55:16
| Melting point | 240.5-241.5° |
|---|---|
| Density | 2.11±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | pKa 8.7 (Uncertain) |
| form | Solid |
| color | Off-white to light yellow |
| Water Solubility | 659g/L(25 ºC) |
| CAS DataBase Reference | 2609-46-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H319-H300-H315-H412 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P310-P321-P330-P405-P501-P273-P501 |
AMILORIDE Chemical Properties,Uses,Production
Description
Amyloride is also a potassium sparing diuretic that exhibits moderate activity. It is not an antagonist of aldosterone. It inhibits reabsorption of sodium ions and reduces excretion of potassium ions.
Uses
Amiloride is an epithelial sodium channel blocker.
Definition
ChEBI: A monocarboxylic acid amide that is N-carbamimidoylpyrazine-2-carboxamide substituted by amino groups at positions 3 and 5 and a chloro group at position 6.
Clinical Use
Amiloride, another potassium-sparing diuretic, is an aminopyrazine structurally related to triamterene as an open-chain analogue. Similar to triamterene, it interferes with the process of cationic exchange in the distal convoluted tubule by blocking luminal sodium channels. It blocks the reabsorption of sodium ion and the secretion of potassium ion. It has no effect on the action of aldosterone. Oral amiloride is approximately 50% absorbed, with a duration of action of 10 to 12 hours, which is slightly longer than that for triamterene. Although triamterene is extensively metabolized, approximately 50% of amiloride is excreted unchanged. Renal impairment can increase its elimination half-life. Like triamterene, amiloride combined with a thiazide or loop diuretic is used to treat edema or hypertension.
AMILORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Anant Pharmaceuticals Pvt Ltd | +91-8550986868 +91-9485998001 | Haryana, India | 461 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | China | 9326 | 58 | Inquiry |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | China | 19947 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| HX Pharmaceutical technology co., LTD | 15671363360 | China | 2581 | 58 | Inquiry |
| ShangHai Anpel Co, Ltd. | 18501792038; 18501792038 | China | 9614 | 58 | Inquiry |
| NORANA GROUP | 027-027-59209883 17386169806 | China | 4602 | 58 | Inquiry |
| Hubei Yunmei Technology Co., Ltd | 027-59206672 18327059871 | China | 5005 | 58 | Inquiry |
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