VALINOMYCIN
- CAS No.
- 2001-95-8
- Chemical Name:
- VALINOMYCIN
- Synonyms
- valinomicin;nsc122023;valamycin;-valyl)[qr];VALINOMYCIN;nsc122023[qr];valinomicin[qr];VALINOMYCIN 99%;Valinomycin,90%;Valinomycin,96%
- CBNumber:
- CB7199194
- Molecular Formula:
- C54H90N6O18
- Molecular Weight:
- 1111.32
- MOL File:
- 2001-95-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/8/30 13:35:17
| Melting point | 187-190 °C |
|---|---|
| alpha | D20 +31.0° (c = 1.6 in benzene) |
| Boiling point | 821.74°C (rough estimate) |
| Density | 1.060 |
| refractive index | 1.6400 (estimate) |
| Flash point | 87℃ |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥10 mg/mL |
| form | solid |
| pka | 11.32±0.70(Predicted) |
| color | white |
| optical activity | [α]20/D +32±2°, c = 1.6% in benzene |
| Water Solubility | Soluble in DMSO at 10mg/ml. Insoluble in water |
| Merck | 13,9976 |
| BRN | 78657 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| EPA Substance Registry System | Valinomycin (2001-95-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310 | |||||||||
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310 | |||||||||
| Hazard Codes | Xn,T,T+,Xi | |||||||||
| Risk Statements | 27/28-36/37/38-21/22 | |||||||||
| Safety Statements | 36-45-36/37-28-37/39-26 | |||||||||
| RIDADR | UN 2811 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YV9468000 | |||||||||
| F | 10-18-21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29419090 | |||||||||
| NFPA 704 |
|
VALINOMYCIN price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | V0627 | Valinomycin ≥98% (TLC), ≥90% (HPLC) | 2001-95-8 | 10MG | ₹9157.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V0627 | Valinomycin ≥98% (TLC), ≥90% (HPLC) | 2001-95-8 | 25MG | ₹16107.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V0627 | Valinomycin ≥98% (TLC), ≥90% (HPLC) | 2001-95-8 | 100MG | ₹40994.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V3639 | Valinomycin Ready Made Solution, ~1?mg/mL in DMSO | 2001-95-8 | 5ML | ₹10267.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V0627 | Valinomycin ≥98% (TLC), ≥90% (HPLC) | 2001-95-8 | 500MG | ₹192988.1 | 2022-06-14 | Buy |
VALINOMYCIN Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumour activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux.
Definition
ChEBI: A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in severa Streptomyces strains.
General Description
Shiny crystalline solid. Used as an insecticide and nematocide. Not registered as a pesticide in the U.S.
Reactivity Profile
VALINOMYCIN is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health Hazard
VALINOMYCIN is highly toxic orally.
Fire Hazard
When heated to decomposition, VALINOMYCIN emits toxic fumes of nitrogen oxides.
Biological Activity
Selective K + ionophore (K 0.5 values are 48, 73, 75, 93 and 246 mM for K + , Rb + , Cs + , Na + and Li + respectively) that transports K + across biological and artificial lipid membranes. Inhibits Ca 2+ -ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro .
Purification Methods
Recrystallise valinomycin from dibutyl ether or Et2O. It is dimorphic: modification A crystallises from n-octane, and modification B crystallises from EtOH/H2O. It is soluble in pet ether, CHCl3, AcOH, BuOAc and Me2CO. [Smith et al. J Am Chem Soc 97 7242 1975, UV, IR and NMR see Brocknmann & Schmidt-Kastner Chem Ber 88 57 1955, Beilstein 27 I 9728. 17 IV 9728.]
VALINOMYCIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29900 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | China | 8828 | 58 | Inquiry |
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