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Ramiprilat

Ramiprilat Structure
CAS No.
87269-97-4
Chemical Name:
Ramiprilat
Synonyms
Ramipley;RAMIPRILAT;Ramiprilate;RAMIPRIL USP;HOE 498 Diacid;Ramipril Diacid;RAMIPRILAT HYDRATE;Ramiprilat USP/EP/BP;Ramipril Impurity 27;RaMipril EP IMpurity E
CBNumber:
CB7231407
Molecular Formula:
C21H28N2O5
Molecular Weight:
388.46
MOL File:
87269-97-4.mol
MSDS File:
SDS
Modify Date:
2024/11/19 23:02:33
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Ramiprilat Properties

Melting point 139-141°C
Boiling point 632.2±55.0 °C(Predicted)
Density 1.273±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 2.20±0.10(Predicted)
color White to Pale Yellow
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/38
Safety Statements  26-37/39
NFPA 704
0
2 0

Ramiprilat Chemical Properties,Uses,Production

Description

Ramiprilat is the active metabolite of ramipril and functions as an angiotensin-converting enzyme inhibitor (pKi = 9.08 in human heart) to suppress the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, thereby preventing vasoconstriction. Furthermore, ramiprilat is reported to interfere with the targeting of B2 kinin receptors to endothelial cell membranes further preventing bradykinin signaling. In addition to its cardioprotective effects in both animal models and clinical studies, ramiprilat has been reported to inhibit matrix metalloproteinase-3 and -9 activity in isolated Crohn’s disease fistulas.

Chemical Properties

White to Off-White Solid

Uses

Ramiprilat (Ramipril EP Impurity E) is a metabolite of Ramipril (R111000), and acts as an ACE inhibitor (1). Reduces the need for dialysis among patients previously on angiotensin-converting-enzyme inhibitors (2). Ramipril is used in stroke prevention. (3)

Definition

ChEBI: A dipeptide that is the active metabolite of ramipril. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.

Ramiprilat Preparation Products And Raw materials

Raw materials

Preparation Products

Ramiprilat Suppliers

Global( 156)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6514 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6739 58 Inquiry
APITORIA PHARMA PRIVATE LTD +91 40 6672 5000 Chongqing, India 110 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49732 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29808 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-89586680 +86-18192503167 China 7859 58 Inquiry
Baoji Guokang Healthchem co.,ltd +8615604608665 15604608665 CHINA 9414 58 Inquiry
CR Corporation Limited +8613062833949 China 8647 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
SynZeal Research Pvt Ltd 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
APITORIA PHARMA PRIVATE LTD 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
TargetMol Chemicals Inc. 58
Shaanxi Dideu Medichem Co. Ltd 58
Baoji Guokang Healthchem co.,ltd 58
CR Corporation Limited 58

87269-97-4(Ramiprilat)Related Search:

Pyrrolidine Polyvinylpyrrolidone N-Methyl-2-pyrrolidone N-Vinyl-2-pyrrolidone Ramipril Diketopiperazine
Ramipril Related Compound A (30 mg) ((2S,3aS,6aS)-1-[(S)2-[[(S)-1-(methoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid) RAMIPRIL RELATED COMPOUND B (20 MG) (RAMIPRIL ISOPROPYLESTER) Ramiprilat Diketopiperazine Carboxy styrene-butadiene latex Ramipril
RAMIPRIL-D3 RAMIPRILAT-D5 ACYL-B-D-GLUCURONIDE RAMIPRIL-D5 ACYL-B-D-GLUCURONIDE RAMIPRILAT ACYL-B-D-GLUCURONIDE RAMIPRILAT-D3
(1R) RAMIPRILAT-D5 Ramiprilat Diketopiperazine-d5 RAMIPRILAT-D5
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RAMIPRILAT RAMIPRILAT HYDRATE Ramiprilat, ammonium salt (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic Acid HOE 498 Diacid Ramipril Diacid (2S,3aS,6aS)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid (2S,3aβ,6aβ)-1-[(S)-2-[[(S)-1-Carboxy-3-phenylpropyl]amino]propionyl]octahydrocyclopenta[b]pyrrole-2α-carboxylic acid Ramiprilate ramiprilat:(2s,3as,6as)-1-((s)-n-((s)-1-carboxy-3-phenylpropyl)alanyl)tetrahydrocyclopenta(b)pyrrole-2-carboxylic acid (2S,3aS,6aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid RaMipril IMpurity-E (EP) RaMipril EP IMpurity E Ramipril EP Impurity E (Ramiprilat) Ramipril Impurity V:Ramiprilat Ramipril EP Imp E (acid) (2S,3aS,6aS)-1-[(S)-2-[[(S)-1-carboxy-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid Ramipril Impurity 1(Ramipril EP Impurity E) (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Car Ramipril impurity Ⅴ(Ramiprilat) Cyclopenta[b]pyrrole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, (2S,3aS,6aS)- Ramiprilat USP/EP/BP Ramipril Impurity 1 （EP Impurity E） Ramipril EP Impurity E (Ramipril Diacid/ Ramiprilat) Ramipley Ramipril EP Impurity EQ: What is Ramipril EP Impurity E Q: What is the CAS Number of Ramipril EP Impurity E Q: What is the storage condition of Ramipril EP Impurity E Q: What are the applications of Ramipril EP Impurity E Ramipril impurity Ⅴ (Ramiprilat) RamiprilEPImpurityE-d5 (2S,3aS,6aS)-1-(((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole RAMIPRIL USP Ramipril Impurity 27 87269-97-4 C21H28N2O5 38846 Various Metabolites and Impurities Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals