Ramipril
![Ramipril Structure](CAS/GIF/87333-19-5.gif)
- CAS No.
- 87333-19-5
- Chemical Name:
- Ramipril
- Synonyms
- ALTACE;RaMipril API;(2s-(1(r*(r*)),2-alpha,3a-beta,6a-beta))-henylpropyl)amino)-1-oxopropyl;2-[[1-(2-ethoxycarbonyl-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrol-1-yl)-1-oxopropan-2-yl]amino]-4-phenylbutanoic acid;DELIX;vesdil;Trimce;RAMACE;Triatec;UNIPRIL
- CBNumber:
- CB0249104
- Molecular Formula:
- C23H32N2O5
- Molecular Weight:
- 416.51
- MOL File:
- 87333-19-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/9/3 18:36:42
Melting point | 106-108°C |
---|---|
Boiling point | 616.2±55.0 °C(Predicted) |
alpha | D24 +33.2° (c = 1 in 0.1N ethanolic HCl) |
Density | 1.200±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: ~18mg/mL |
pka | pKa 3.30±0.01(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain);5.75±0.00(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain) |
form | powder |
color | white |
BCS Class | 1 |
CAS DataBase Reference | 87333-19-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS08 |
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Signal word | Danger | |||||||||
Hazard statements | H360FD | |||||||||
Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/38 | |||||||||
Safety Statements | 26-37/39 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | GY5879600 | |||||||||
HS Code | 2933995300 | |||||||||
Toxicity | LD50 (14 day) in male, female mice, male, female rats (mg/kg): 1194, 1158, 687, 608 i.v.; 10933, 10048, >10000, >10000 orally (Donaubauer, Mayer) | |||||||||
NFPA 704 |
|
Ramipril price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | R0404 | Ramipril ≥98% (HPLC) | 87333-19-5 | 100MG | ₹23111.38 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | R0404 | Ramipril ≥98% (HPLC) | 87333-19-5 | 250MG | ₹46893.9 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PHR1446 | Ramipril Pharmaceutical Secondary Standard; Certified Reference Material | 87333-19-5 | 1G | ₹9926.53 | 2022-06-14 | Buy |
TCI Chemicals (India) | R0219 | Ramipril | 87333-19-5 | 1G | ₹7000 | 2022-05-26 | Buy |
TCI Chemicals (India) | R0219 | Ramipril | 87333-19-5 | 5G | ₹14200 | 2022-05-26 | Buy |
Ramipril Chemical Properties,Uses,Production
Description
Ramipril, a prodrug of ramiprilat, is a long-acting, tissue-specific and non-sulfhydryl ACE inhibitor useful in the treatment of mild to moderate hypertension. In animal studies ramipril exerted cardioprotective effects resembling those of bradykinin in cardiac reperfusion injuries. Ramipril is also reportedly useful in congestive heart failure.
Chemical Properties
White Solid
Uses
Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes. Ramipril is a second generation ACE inhibitor (IC50 = 4 nM) that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. The antihypertensive and cardioprotective efficacy of ramipril has been demonstrated in large-scale noncomparative studies and clinical trials.[Cayman Chemical]
Definition
ChEBI: A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.
General Description
Ramipril, (2S, 3aS, 6aS)-1-[(S)-N-[(S)-1-carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]-pyrrole-2-carboxylic acid 1-ethyl ester (Altace), ishydrolyzed to ramiprilat, its active diacid form, faster thanenalapril is hydrolyzed to its active diacid form. Peak serumconcentrations from a single oral dose are achieved between1.5 and 3 hours. The ramiprilate formed completely suppresses ACE activity for up to 12 hours, with 80% inhibitionof the enzyme still observed after 24 hours.
Ramipril Preparation Products And Raw materials
Raw materials
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Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
AARTI INDUSTRIES LIMITED | 912267976666 | New Delhi, India | 172 | 58 | Inquiry |
Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
S.V ENTERPRISES | +919322701159 | Mumbai, India | 150 | 58 | Inquiry |
AnalyticsStanza Inc | +91-7032031309 +91-7032031309 | Hyderabad, India | 227 | 58 | Inquiry |
Aarti Industries Limited (AIL) | +91-84596144931 +91-9920899935 | Maharashtra, India | 235 | 58 | Inquiry |
Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
MELODY HEALTHCARE PVT LTD | +undefined2228780912 | Maharashtra, India | 20 | 58 | Inquiry |
HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
Supplier | Advantage |
---|---|
AARTI INDUSTRIES LIMITED | 58 |
Dr. Reddy's Laboratories Ltd | 58 |
S.V ENTERPRISES | 58 |
AnalyticsStanza Inc | 58 |
Aarti Industries Limited (AIL) | 58 |
Hetero Drugs Limited | 58 |
MELODY HEALTHCARE PVT LTD | 58 |
HRV Global Life Sciences | 58 |
Varanous Labs Pvt Ltd | 58 |
Cipla Ltd | 58 |
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