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Ramipril

Ramipril Structure
CAS No.
87333-19-5
Chemical Name:
Ramipril
Synonyms
ALTACE;RaMipril API;(2s-(1(r*(r*)),2-alpha,3a-beta,6a-beta))-henylpropyl)amino)-1-oxopropyl;2-[[1-(2-ethoxycarbonyl-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrol-1-yl)-1-oxopropan-2-yl]amino]-4-phenylbutanoic acid;DELIX;vesdil;Trimce;RAMACE;Triatec;UNIPRIL
CBNumber:
CB0249104
Molecular Formula:
C23H32N2O5
Molecular Weight:
416.51
MOL File:
87333-19-5.mol
MSDS File:
SDS
Modify Date:
2024/9/3 18:36:42

Ramipril Properties

Melting point 106-108°C
Boiling point 616.2±55.0 °C(Predicted)
alpha D24 +33.2° (c = 1 in 0.1N ethanolic HCl)
Density 1.200±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ~18mg/mL
pka pKa 3.30±0.01(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain);5.75±0.00(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain)
form powder
color white
BCS Class 1
CAS DataBase Reference 87333-19-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H360FD
Precautionary statements  P201-P202-P280-P308+P313-P405-P501
Hazard Codes  Xi
Risk Statements  36/38
Safety Statements  26-37/39
WGK Germany  2
RTECS  GY5879600
HS Code  2933995300
Toxicity LD50 (14 day) in male, female mice, male, female rats (mg/kg): 1194, 1158, 687, 608 i.v.; 10933, 10048, >10000, >10000 orally (Donaubauer, Mayer)
NFPA 704
0
2 0

Ramipril price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) R0404 Ramipril ≥98% (HPLC) 87333-19-5 100MG ₹23111.38 2022-06-14 Buy
Sigma-Aldrich(India) R0404 Ramipril ≥98% (HPLC) 87333-19-5 250MG ₹46893.9 2022-06-14 Buy
Sigma-Aldrich(India) PHR1446 Ramipril Pharmaceutical Secondary Standard; Certified Reference Material 87333-19-5 1G ₹9926.53 2022-06-14 Buy
TCI Chemicals (India) R0219 Ramipril 87333-19-5 1G ₹7000 2022-05-26 Buy
TCI Chemicals (India) R0219 Ramipril 87333-19-5 5G ₹14200 2022-05-26 Buy
Product number Packaging Price Buy
R0404 100MG ₹23111.38 Buy
R0404 250MG ₹46893.9 Buy
PHR1446 1G ₹9926.53 Buy
R0219 1G ₹7000 Buy
R0219 5G ₹14200 Buy

Ramipril Chemical Properties,Uses,Production

Description

Ramipril, a prodrug of ramiprilat, is a long-acting, tissue-specific and non-sulfhydryl ACE inhibitor useful in the treatment of mild to moderate hypertension. In animal studies ramipril exerted cardioprotective effects resembling those of bradykinin in cardiac reperfusion injuries. Ramipril is also reportedly useful in congestive heart failure.

Chemical Properties

White Solid

Uses

Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes. Ramipril is a second generation ACE inhibitor (IC50 = 4 nM) that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. The antihypertensive and cardioprotective efficacy of ramipril has been demonstrated in large-scale noncomparative studies and clinical trials.[Cayman Chemical]

Definition

ChEBI: A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.

General Description

Ramipril, (2S, 3aS, 6aS)-1-[(S)-N-[(S)-1-carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]-pyrrole-2-carboxylic acid 1-ethyl ester (Altace), ishydrolyzed to ramiprilat, its active diacid form, faster thanenalapril is hydrolyzed to its active diacid form. Peak serumconcentrations from a single oral dose are achieved between1.5 and 3 hours. The ramiprilate formed completely suppresses ACE activity for up to 12 hours, with 80% inhibitionof the enzyme still observed after 24 hours.

Global( 427)Suppliers
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AARTI INDUSTRIES LIMITED 912267976666 New Delhi, India 172 58 Inquiry
Dr. Reddy's Laboratories Ltd +91-4049002900 +91-4049002900 Hyderabad, India 165 58 Inquiry
S.V ENTERPRISES +919322701159 Mumbai, India 150 58 Inquiry
AnalyticsStanza Inc +91-7032031309 +91-7032031309 Hyderabad, India 227 58 Inquiry
Aarti Industries Limited (AIL) +91-84596144931 +91-9920899935 Maharashtra, India 235 58 Inquiry
Hetero Drugs Limited +91-4023704923 +91-4023704923 Telangana, India 296 58 Inquiry
MELODY HEALTHCARE PVT LTD +undefined2228780912 Maharashtra, India 20 58 Inquiry
HRV Global Life Sciences +91-9820219686 +91-9820219686 Telangana, India 379 58 Inquiry
Varanous Labs Pvt Ltd +91-7036248882 +91-7036248882 Hyderabad, India 1541 58 Inquiry
Cipla Ltd +912224826000 Maharashtra, India 133 58 Inquiry

Ramipril Spectrum

Ramioril (2S,3AS,6AS)-1-((S)-2-((S)-1-ETHOXY-1-OXO-4-PHENYLBUTAN-2-YLAMINO)PROPANOYL)-OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID Triatec Trimce vesdil (1S,5S,7S)-8-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-8-azabicyclo[3.3.0]octane-7-carboxylic acid Cyclopenta(b)pyrrole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl) amino)-1-oxopropyl), (2S-(1(R*(R*)),2-alpha,3a-beta,6a-beta)) 4-[2-(1-Ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]-4-azabicyclo[3.3.0]octane-3-carboxylic acid (2S,3aβ,6aβ)-1-[(S)-2-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2α-carboxylic acid Ramipril (125 mg) Tritace, [2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid [2S-[1[R^<*>^ (R^<*>^)],2α,3αβ,6αβ]]-1-[2-[[1- (Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahy-drocyclopenta[b]pyrrole-2-carboxylic acid (2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid RaMipril(Altace) (2S,3aS,6aS)- Ranipril UNIPRIL TRITACE PRAMACE RAMIPRIL RAMACE cyclopenta(b)pyrrole-2-carboxylicacid,octahydro-1-(2-((1-(ethoxycarbonyl)-3-p [2S,3AS,6AS]-1-[(2S)-2-[[(1S)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL]AMINO]-1-OXOPROPYL]OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID (2S,3AS,6AS)-1-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-OCTAHYDRO-CYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID (2s,3as,6as)-1((s)-n-((s)-1-carboxy-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid 1-ethyl ester RAMIPRIL, IMPURITY B(2S,3AS,6AS)-1-[(S)-2-[[(S)-1-[(METHYLETHOXY)CARBONYL]-3-PHENYLPROPYL]AMINO] PROPANOYL]OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID(RAMIPRIL ISOPROPYL ESTER) EP STANDARD RAMIPRIL, USP STANDARD RAMIPRIL, EP STANDARD RAMIPRIL, RELATED COMPOUND A5-[[2-(AMINOETHYL)THIO]METHYL]-N,N-DIMETHYL-2-FURANMETHANINE HEMIFUMARATE SALT USP STANDARD RAMIPRIL, IMPURITY DETHYL(2S)-2-[(3S,5AS,8AS,9AS)-3-METHYL-1,4-DIOXODECAHYDRO-1H-CYCLOPENTA[E]PYRROLO[1,2A]PYRAZIN-2-YL]-4-PHENYLBUTANOATE EP STANDARD RAMIPRIL, IMPURITY C(2S,3AS,6AS)-1-[(S)-2-[[(S)-1-(ETHOXYCARBONYL)-3-CYCLOHEXYLPROPYL]AMINO]PROPANOYL]OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID (HEXAHYDRORAMIPRIL) EP STANDARD RAMIPRIL, IMPURITY A(2S,3AS,6AS)-1-[(S)-2-[[(S)-1-(METHOXYCARBONYL)-3-PHENYLPROPYL]AMINO]PROPANOLY]OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID (RAMIPRIL METHYLESTER) EP STANDARD CARDACE HOE-498 DELIX Raimipril RamiprilC23H32N205 HOE-498, Altace, Cardace, Delix, Pramace, Ramace, Unipril Cyclopentabpyrrole-2-carboxylic acid, 1-(2S)-2-(1S)-1-(ethoxycarbonyl)-3-phenylpropylamino-1-oxopropyloctahydro-, (2S,3aS,6aS)- (2s,3as,6as)-1-[(s)-2-[[(s)-1-(ethoxycarbonyl)-3phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid cyclopenta(b)pyrrole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-phoeramipril (2S,3aS,6aS)-1-((S)-2-((S)-1-ethoxy-1-oxo-4- CAS 87333-19-5 Ramipril Powder 2S,3aS,6aS)-1((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid 1-ethyl ester Ramipril CRS Calcipotriol impurity MC-1080 Carasel Ramipril USP/EP/BP Ramipril (1.0 mg/mL in Methanol) Ramipri Ramipril (HOE-498) RamiprilQ: What is Ramipril Q: What is the CAS Number of Ramipril Q: What is the storage condition of Ramipril Q: What are the applications of Ramipril Ramipril (1598303) (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid RaMipril API (2s-(1(r*(r*)),2-alpha,3a-beta,6a-beta))-henylpropyl)amino)-1-oxopropyl ALTACE 2-[[1-(2-ethoxycarbonyl-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrol-1-yl)-1-oxopropan-2-yl]amino]-4-phenylbutanoic acid