Ramipril
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Ramipril 속성
- 녹는점
- 106-108°C
- 끓는 점
- 616.2±55.0 °C(Predicted)
- 알파
- D24 +33.2° (c = 1 in 0.1N ethanolic HCl)
- 밀도
- 1.200±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: ~18mg/mL
- 산도 계수 (pKa)
- pKa 3.30±0.01(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain);5.75±0.00(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain)
- 물리적 상태
- 가루
- 색상
- 하얀색
- BCS Class
- 1
- CAS 데이터베이스
- 87333-19-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/38 | ||
안전지침서 | 26-37/39 | ||
WGK 독일 | 2 | ||
RTECS 번호 | GY5879600 | ||
HS 번호 | 2933995300 | ||
유해 물질 데이터 | 87333-19-5(Hazardous Substances Data) | ||
독성 | LD50 (14 day) in male, female mice, male, female rats (mg/kg): 1194, 1158, 687, 608 i.v.; 10933, 10048, >10000, >10000 orally (Donaubauer, Mayer) |
Ramipril C화학적 특성, 용도, 생산
개요
Ramipril, a prodrug of ramiprilat, is a long-acting, tissue-specific and non-sulfhydryl ACE inhibitor useful in the treatment of mild to moderate hypertension. In animal studies ramipril exerted cardioprotective effects resembling those of bradykinin in cardiac reperfusion injuries. Ramipril is also reportedly useful in congestive heart failure.화학적 성질
White Solid용도
Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes. Ramipril is a second generation ACE inhibitor (IC50 = 4 nM) that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. The antihypertensive and cardioprotective efficacy of ramipril has been demonstrated in large-scale noncomparative studies and clinical trials.[Cayman Chemical]정의
ChEBI: A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.일반 설명
Ramipril, (2S, 3aS, 6aS)-1-[(S)-N-[(S)-1-carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]-pyrrole-2-carboxylic acid 1-ethyl ester (Altace), ishydrolyzed to ramiprilat, its active diacid form, faster thanenalapril is hydrolyzed to its active diacid form. Peak serumconcentrations from a single oral dose are achieved between1.5 and 3 hours. The ramiprilate formed completely suppresses ACE activity for up to 12 hours, with 80% inhibitionof the enzyme still observed after 24 hours.Ramipril 준비 용품 및 원자재
원자재
Ethyl 3-benzoylacrylate
Palladium carbon fine chemical catalyzer
Benzyl ester
사이클로헥세인
L-알라닌
사이클로펜텐
초산에틸
디클로로메탄
아세트산(빙초산)
메틸 프로피오네이트
피롤리딘
포름아미드
2-아자비시클로[3.3.0]옥탄-3-카르복실산
Benzenebutanoic acid, α-[[(1S)-2-chloro-1-methyl-2-oxoethyl]amino]-, ethyl ester, hydrochloride (αS)-
2-[N-[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]-L-ALANYL]-(1S,3S,5S)-2-AZABICYCLO[3.3.0]OCTANE-3-CARBOXYLIC ACID, BENZYL ESTER
Ethyl (S)-2-[(S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]-4-phenylbutyrate
준비 용품
Ramipril 공급 업체
글로벌( 429)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5895 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 |
sales@ichemie.com | China | 990 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20291 | 58 |
Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 295 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 |
sarah@tnjone.com | China | 1143 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21663 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Ramipril 관련 검색:
노르말옥탄 2,2,4-트리메칠펜탄 1-옥탄술폰 산, 나트륨 염 폴리(옥시프로필렌)디아민 니켈카르보닐
Valsartan
RAMIPRIL IMPURITY B
RAMIPRIL IMPURITY C
(S,S,S)-2-Azabicyclo[3,3,0]-octane-carboxylic acid benzylester hydrochloride
Carbonyl iron powder
ENDO, CIS-2-AZABICYCLO [3,3,0] OCTANE-3-CARBORYLIC ACID BENZYL ESTER HYDROCHLORIDE (FOR RAMIPRIL)
Ramipril Related Compound B
Ramiprilat
RAMIPRIL IMPURITY A
Ritonavir Related Compounds Mixture
Ramipril Diketopiperazine
RAMIPRIL RELATED COMPOUND B (20 MG) (RAMIPRIL ISOPROPYLESTER)
2-[N-[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]-L-ALANYL]-(1S,3S,5S)-2-AZABICYCLO[3.3.0]OCTANE-3-CARBOXYLIC ACID, BENZYL ESTER