2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE
![2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Structure](CAS/GIF/479683-64-2.gif)
- CAS No.
- 479683-64-2
- Chemical Name:
- 2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE
- Synonyms
- CS-687;CP809101;CP-809101;CP 809101;CP809101/CP-809101;CP 809101 hydrochlor;CP-809102 hydrochloride;CP 809101 HYDROCHLORIDE;Pyrazine, 2-[(3-chlorophenyl)methoxy]-6-(1-piperazinyl)-;6'-(3-Chlorobenzyloxy)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine
- CBNumber:
- CB72454336
- Molecular Formula:
- C15H17ClN4O
- Molecular Weight:
- 304.77
- MOL File:
- 479683-64-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:10
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| NFPA 704 |
|
2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE price More Price(2)
2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
CP 809101 is a potent and selective SR-2C and 5-HT2C agonist.
Biological Activity
Potent and selective 5-HT 2C receptor agonist (pEC 50 values are 9.96, 7.19 and 6.81 for human 5-HT 2C , 5-HT 2B and 5-HT 2A receptors respectively). Displays antipsychotic activity; suppresses condition avoidance responding (CAR) and inhibits PCP and amphetamine-stimulated hyperactivity in rats following subcutaneous administration.
Biochem/physiol Actions
CP-809,101 is a potent and high-affinity 5-hydroxytryptamine receptor 2C (5-HT2C) full agonist with only weaker partial agonist activity toward 5-HT2A & 5-HT2B (cellular Ca2+ mobilization EC50 in nM/efficiency = 0.11/93% and 0.06/97% with human and rat 5-HT2C, respectively; 153/67%/human 5HT2A, 65.3/57%/human 5HT2B, 119/79%/rat 5HT2A) and much reduced or little affinity toward other receptors, ion channels and uptake sites tested. CP-809,101 exhibits antipsychotic efficacy in reducing conditioned avoidance response/CAR (ED50 = 4.8 mg/kg s.c.) and locomotor activity (ED50 in mg/kg via s.c. = 2/rats, 1/mice; no effect up to 10 mg/kg in 5-HT2C-knockout mice), while oral administration is reported to suppress spontaneous and nocturnal food intake as well as fasting-induced refeeding in rats (～8% and ～24% reduction of cumulative food intake and body weight in 4 days, respectively; 30 mg/kg/day p.o.).
2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Suppliers
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