Difluoromethyl 2-pyridyl sulfone
- CAS No.
- 1219454-89-3
- Chemical Name:
- Difluoromethyl 2-pyridyl sulfone
- Synonyms
- 2-PySO2CF2H;2-[(DifL;Hu Reagent;DFM-2-pyridyl sulfone;2-Pyridyl difluoromethyl sulfone;DifluoroMethyl 2-Pyridyl Sulfone;2-(Difluoromethanesulfonyl)pyridine;2-[(DifluoroMethyl)sulfonyl]pyridine;Pyridine, 2-[(difluoroMethyl)sulfonyl]-;Difluoromethyl 2-pyridyl sulfone 97% (HPLC)
- CBNumber:
- CB72614473
- Molecular Formula:
- C6H5F2NO2S
- Molecular Weight:
- 193.17
- MOL File:
- 1219454-89-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/15 18:41:30
Melting point | 47.0 to 51.0 °C |
---|---|
Boiling point | 324.4±42.0 °C(Predicted) |
Density | 1.423±0.06 g/cm3(Predicted) |
storage temp. | -20°C Freezer, Under inert atmosphere |
solubility | Chloroform (Slightly), Methanol (Slightly) |
pka | -2.60±0.19(Predicted) |
form | Solid |
color | Off-White |
BRN | 20317604 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H301-H319 | |||||||||
Precautionary statements | P301+P310-P305+P351+P338 | |||||||||
Hazard Codes | T | |||||||||
Risk Statements | 25-36 | |||||||||
Safety Statements | 26-45-24/25 | |||||||||
RIDADR | UN 2811 6.1 / PGIII | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 29339900 | |||||||||
NFPA 704 |
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Difluoromethyl 2-pyridyl sulfone price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 746061 | Difluoromethyl 2-pyridyl sulfone 97% (HPLC) | 1219454-89-3 | 1G | ₹7187.8 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 746061 | Difluoromethyl 2-pyridyl sulfone 97% (HPLC) | 1219454-89-3 | 5G | ₹33557.5 | 2022-06-14 | Buy |
TCI Chemicals (India) | D5390 | Difluoromethyl 2-Pyridyl Sulfone min. 98.0 % | 1219454-89-3 | 1G | ₹8200 | 2022-05-26 | Buy |
Difluoromethyl 2-pyridyl sulfone Chemical Properties,Uses,Production
Description
Difluoromethyl 2-pyridyl sulfone, also known as Hu reagent, is a novel and efficient gem-difluoroolefination reagent for preparing gem-difluoroalkenes from both aldehydes and ketones. The fluorinated sulfinate intermediates during the gem-difluoroolefination is relatively stable, and can be halogenated in situ to afford bromo- and iododifluoromethyl compounds. It can also act as nucleophilic difluoro(sulfonato)methylation reagent for the synthesis of α,α-difluorosulfonates from aldehydes, and alkyl halides and triflates.
Chemical Properties
Melting point 48-50°C, boiling point 324.4+42°C, relative density 1.423+0.06 g/cm3 , slightly soluble in water, casily soluble in acctonitrile and methanol.
Uses
2-[(Difluoromethyl)sulfonyl]pyridine is a new novel gem-difluoroolefination reagent for both aldehydes and ketones.
Application
- Difluoromethyl 2-pyridyl sulfone can be used for the introduction of difluoromethylene, as a difluoroalkylation reagent to reacwith aldehydes and ketones to prepare difluoroalkenesIt can be used for the introduction of difluoromethyl, reacting with aryl zine and aryl iodine to preparedifluoromethyl aryl compounds, and conducting free radical addition reactions with olefins.
- It can be used as a nucleophilic difluoro (sulfonation) methylation reagent for synthesis from aldehydes.ketones, alkyl halides, trifluoromethanesulfonic acid esters, etc a,a- Difluoroalkyl sulfinates andsulfonates.
- It can also be used together with electrophilic iodination reagents and bromination reagents for theintroduction ofmonoiododifluoromethyl and monobromodifluoromethyl groups.
- It can also be used as a 2-pyridylation reagent.
Reactions
(1) gem-Difluoroolefination of aldehydes and ketones.
(2) Halodifluoromethylation of aldehydes and ketones.
(3) (Fluorosulfonyl)difluoromethylation of aldehydes and ketones.
(4) Difluoro(sulfonato)methylation of alkyl halides and triflates.
(5) Aromatic difluoromethylation
General Description
Difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H) is a reagent used in the gem-difluoroolefination of aldehydes and ketones. It is also used as a reagent in the nucleophilic difluoro(sulfonato)methylation of alcohols, N-sulfinyl imines, and halides.
References
[1] WENJUN MIAO. Nickel-Catalyzed Reductive 2-Pyridination of Aryl Iodides with Difluoromethyl 2-Pyridyl Sulfone[J]. Organic Letters, 2021, 23 3: 711-715. DOI:10.1021/acs.orglett.0c03939.
[2] WENJUN MIAO. Nucleophilic Iododifluoromethylation of Carbonyl Compounds Using Difluoromethyl 2-Pyridyl Sulfone[J]. Organic Letters, 2016, 18 11: 2766-2769. DOI:10.1021/acs.orglett.6b01258.
[3] YANCHUAN ZHAO. Difluoromethyl 2-Pyridyl Sulfone: A New gem-Difluoroolefination Reagent for Aldehydes and Ketones[J]. Organic Letters, 2010, 12 7: 1444-1447. DOI:10.1021/ol100090r.
Difluoromethyl 2-pyridyl sulfone Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10977 | 58 | Inquiry |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10312 | 58 | Inquiry |
Accela ChemBio Inc. | +1-858-6993322 | United States | 19309 | 58 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | China | 5791 | 58 | Inquiry |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
Labnetwork lnc. | +86-27-50766799 +8618062016861 | China | 19994 | 58 | Inquiry |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |