Difluoromethyl phenyl sulfone
- CAS No.
- 1535-65-5
- Chemical Name:
- Difluoromethyl phenyl sulfone
- Synonyms
- PhSO2CF2H;[(Difluoromethyl)sulfonyl]benzene;Difluoromethyl phenyl sul;Phenyl difluoromethyl sulfone;Difluoromethyl phenyl sulfone;Difluoromethylphenylsulfone,95%;Difluoromethyl Phenyl Sulfone >1-(difluoroMethylsulfonyl)benzene;Difluoromethyl phenyl sulfone >=97%;Benzene, [(difluoroMethyl)sulfonyl]-
- CBNumber:
- CB72485024
- Molecular Formula:
- C7H6F2O2S
- Molecular Weight:
- 192.18
- MOL File:
- 1535-65-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/15 18:41:30
| Melting point | 24-25℃ |
|---|---|
| Boiling point | 115-120 °C(Press: 7 Torr) |
| Density | 1.348 |
| refractive index | 1.5000 |
| Flash point | 128℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | liquid |
| color | colorless |
| Water Solubility | Soluble in chloroform and water. |
| BRN | 2259218 |
Difluoromethyl phenyl sulfone price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 742600 | Difluoromethyl phenyl sulfone ≥97% | 1535-65-5 | 1G | ₹5542.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 742600 | Difluoromethyl phenyl sulfone ≥97% | 1535-65-5 | 10G | ₹45345.93 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D4764 | Difluoromethyl Phenyl Sulfone min. 98.0 % | 1535-65-5 | 1G | ₹4300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D4764 | Difluoromethyl Phenyl Sulfone min. 98.0 % | 1535-65-5 | 5G | ₹20700 | 2022-05-26 | Buy |
Difluoromethyl phenyl sulfone Chemical Properties,Uses,Production
Description
Difluoromethyl phenyl sulfone is a powerful nucleophilic difluoromethylation reagent due to the high reactivity of the sulfonyl-stabilized difluoromethyl anion towards many electrophiles including carbonyls, imines, alkyl halides, and cyclic sulfates and sulfamidates. In the nucleophilic reaction step, depending on the substrate structure, strong bases are used to generate the nucleophilic (phenylsulfonyl)difluoromethyl anion in situ. In the desulfonylation step, sodium/mercury amalgam and magnesium are the commonly used reductive reagents. Besides, the (phenylsulfonyl)difluoromethylated compounds can undergo β-elimination to afford gem-difluoroalkenes.
Chemical Properties
light yellow liquid
Uses
Difluoromethyl Phenyl Sulfone has been used as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls
Reactions
(1) Difluoromethylation of alkyl halides.
(2) Difluoromethylation of aldehydes and ketones.
(3) Difluoromethylenation of aldimines and ketimines.
(4) Difluoromethylation of cyclic sulfates and sulfamidates.
(5) (Phenylsulfonyl)difluoromethylation of carboxylic acid esters.
(6) Difluoromethylenation of alkyl halides.
(7) Difluoromethylenation of aromatic aldehydes.
References
[1] G. PRAKASH. Nucleophilic difluoromethylation of primary alkyl halides using difluoromethyl phenyl sulfone as a difluoromethyl anion equivalent.[J]. Organic Letters, 2004. DOI:10.1002/CHIN.200509059.
[2] G. K. SURYA PRAKASH. Difluoromethyl Phenyl Sulfone, a Difluoromethylidene Equivalent: Use in the Synthesis of 1,1-Difluoro-1-alkenes.[J]. ChemInform, 2005. DOI:10.1002/chin.200504098.
[3] G. K. SURYA PRAKASH. Nucleophilic Difluoromethylation of Primary Alkyl Halides Using Difluoromethyl Phenyl Sulfone as a Difluoromethyl Anion Equivalent[J]. Organic Letters, 2004, 6 23: 4315-4317. DOI:10.1021/ol048166i.
Difluoromethyl phenyl sulfone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Gagri Global IT Services Pvt. Ltd. | +91-40-27170174, | Telangana, India | 1321 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10978 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 16858 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | China | 5791 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |