(Difluoromethyl)trimethylsilane
- CAS No.
- 65864-64-4
- Chemical Name:
- (Difluoromethyl)trimethylsilane
- Synonyms
- Difluormethyltrimethylsilan;(DifluoroMethyl)triMethylsilane;TriMethyl(difluoroMethyl)silane;Silane, (difluoroMethyl)triMethyl-;(Difluoromethyl)trimethylsilane>(Difluoromethyl)trimethylsilane,97%;(Difluoromethyl)trimethylsilane >=98.0% (GC)
- CBNumber:
- CB02610597
- Molecular Formula:
- C4H10F2Si
- Molecular Weight:
- 124.2
- MOL File:
- 65864-64-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/15 18:41:30
| Boiling point | 52°C(lit.) |
|---|---|
| Density | 0.877±0.06 g/cm3(Predicted) |
| refractive index | 1.3560-1.3600 |
| Flash point | -17℃ |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Specific Gravity | 0.91 |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| BRN | 2423974 |
| InChIKey | OOKFLLNDYNWCHK-UHFFFAOYSA-N |
| CAS DataBase Reference | 65864-64-4 |
(Difluoromethyl)trimethylsilane price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 744050 | (Difluoromethyl)trimethylsilane ≥98.0% (GC) | 65864-64-4 | 1ML | ₹16183.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 744050 | (Difluoromethyl)trimethylsilane ≥98.0% (GC) | 65864-64-4 | 5ML | ₹83872.1 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D4364 | (Difluoromethyl)trimethylsilane min. 97.0 % | 65864-64-4 | 1ML | ₹7800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D4364 | (Difluoromethyl)trimethylsilane min. 97.0 % | 65864-64-4 | 5ML | ₹23500 | 2022-05-26 | Buy |
(Difluoromethyl)trimethylsilane Chemical Properties,Uses,Production
Description
A direct nucleophilic difluoromethylation reagent. The nucleophilic activation of the silicon center with Lewis base initiators allows transfer of the difluoromethyl moiety to electrophiles such as aldehydes, ketones, and aldimines. The copper-mediated difluoromethylation of halides using TMSCF2H tolerates amine, ether, amide, ester, aromatic bromide, and protected alcohol functionalities in aryl iodides and occurs in high yield and stereoselectivity with vinyl iodides.
Reactions
(1) Direct bromination to prepare TMSCF2Br.
(2) Difluoromethylation of aldehydes and ketones.
(3) Difluoromethylation of aldimines.
(4) Difluoromethylation of aryl and vinyl iodides.
References
[1] MIKHAIL D. KOSOBOKOV. Difluoro(trimethylsilyl)acetonitrile: Synthesis and Fluoroalkylation Reactions[J]. The Journal of Organic Chemistry, 2012, 77 13: 5850-5855. DOI:10.1021/jo301094b.
[2] YANCHUAN ZHAO. Efficient and Direct Nucleophilic Difluoromethylation of Carbonyl Compounds and Imines with Me3SiCF2H at Ambient or Low Temperature[J]. Organic Letters, 2011, 13 19: 5342-5345. DOI:10.1021/ol202208b.
[3] PATRICK S. FIER John F H. Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides[J]. Journal of the American Chemical Society, 2012, 134 12: 5524-5527. DOI:10.1021/ja301013h.
(Difluoromethyl)trimethylsilane Preparation Products And Raw materials
Raw materials
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