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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Stem Cells & Wnt >Wnt / beta-catenin inhibitors >LGK-974

LGK-974

LGK-974 Structure
CAS No.
1243244-14-5
Chemical Name:
LGK-974
Synonyms
LGK-974;WNT-974;CS-1102;NVP-LGK974;LGK974 (WNT974);LGK974; LGK-974;LGK-974 USP/EP/BP;LGK974(NVP-LGK974);LGK974; LGK 974; NVP-LGK974;7'-Dichlorodihydrofluorescein diacetate
CBNumber:
CB72655412
Molecular Formula:
C23H20N6O
Molecular Weight:
396.44
MOL File:
1243244-14-5.mol
Modify Date:
2023/8/29 17:14:30
Request For Quotation

LGK-974 Properties

Melting point 176 - 180°C
Boiling point 650.9±55.0 °C(Predicted)
Density 1.268±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly)
pka 12.24±0.70(Predicted)
form Solid
color White to Off-White

SAFETY

Risk and Safety Statements

HS Code  2933399990

LGK-974 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 5.31091 Porcn Inhibitor IV, LGK974 - CAS 1243244-14-5 - Calbiochem A cell-permeable inhibitor of Wnt secretion from L-cell Wnt1/2/3/3a/6/7a/9a transfectants (IC?? from 50 pM to 1.1 nM). 1243244-14-5 5MG ₹20010 2022-06-14 Buy
Product number Packaging Price Buy
5.31091 5MG ₹20010 Buy

LGK-974 Chemical Properties,Uses,Production

Description

Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. LGK974 is a potent and specific small molecule inhibitor of PORCN (IC50 = 0.4 nM). It greatly reduces Wnt secretion without decreasing its synthesis and without increasing cytotoxicity. LGK974 is orally bioavailable in mice and induces tumor regression in mouse breast tumors produced by mammary tumor virus-driven Wnt1 signaling. It also blocks carcinogenesis in other Wnt-related tumors at doses that have limited impact on stem cell renewal.

Uses

LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor.

LGK-974 Preparation Products And Raw materials

Raw materials

Preparation Products

LGK-974 Suppliers

Global( 115)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Shaanxi Haibo Biotechnology Co., Ltd +undefined18602966907 China 1000 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26165 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Labnetwork lnc. +86-27-50766799 +8618062016861 China 19994 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Shaanxi Haibo Biotechnology Co., Ltd 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
Labnetwork lnc. 58
InvivoChem 58

LGK-974 Spectrum

LGK-974(1243244-14-5)1HNMR

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LGK974(NVP-LGK974) 2-[5-Methyl-6-(2-methyl-4-pyridyl)-3-pyridyl]-N-(5-pyrazin-2-yl-2-pyridyl)acetamide LGK-974 2-(2',3-diMethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetaMide 2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide [2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]- NVP-LGK974 LGK-974 2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide 7'-Dichlorodihydrofluorescein diacetate 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide LGK-974 USP/EP/BP LGK974 (WNT974) WNT-974 LGK974; LGK 974; NVP-LGK974 2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide hydrochloride 2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide LGK974; LGK-974 CS-1102 Acotiamide Impurity LGK（Acotiamide Impurity 43） Acotiamide Impurity LGK or Acotiamide Impurity 43 2 ', 3-dimethyl-N - [5- (2-pyrazinyl) -2-pyridyl] - [2,4' - bipyridine] -5-acetamide 2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide 1243244-14-5 243244-14-5 Inhibitors