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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Stem Cells & Wnt >Wnt / beta-catenin inhibitors >LGK-974

LGK-974

LGK-974 Structure
  • ₹20010
  • Product name: LGK-974
  • CAS: 1243244-14-5
  • MF: C23H20N6O
  • MW: 396.44
  • EINECS:
  • MDL Number:MFCD27501026
  • Synonyms:LGK974(NVP-LGK974);2-[5-Methyl-6-(2-methyl-4-pyridyl)-3-pyridyl]-N-(5-pyrazin-2-yl-2-pyridyl)acetamide;LGK-974;2-(2',3-diMethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetaMide;2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide;[2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-;NVP-LGK974;LGK-974 2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide
Price1 Properties Safety Information Description
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product number5.31091
  • Product descriptionPorcn Inhibitor IV, LGK974 - CAS 1243244-14-5 - Calbiochem A cell-permeable inhibitor of Wnt secretion from L-cell Wnt1/2/3/3a/6/7a/9a transfectants (IC?? from 50 pM to 1.1 nM).
  • Packaging5MG
  • Price₹20010
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 5.31091 Porcn Inhibitor IV, LGK974 - CAS 1243244-14-5 - Calbiochem A cell-permeable inhibitor of Wnt secretion from L-cell Wnt1/2/3/3a/6/7a/9a transfectants (IC?? from 50 pM to 1.1 nM). 5MG ₹20010 2022-06-14 Buy

Properties

Melting point :176 - 180°C
Boiling point :650.9±55.0 °C(Predicted)
Density :1.268±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :12.24±0.70(Predicted)
form :Solid
color :White to Off-White

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. LGK974 is a potent and specific small molecule inhibitor of PORCN (IC50 = 0.4 nM). It greatly reduces Wnt secretion without decreasing its synthesis and without increasing cytotoxicity. LGK974 is orally bioavailable in mice and induces tumor regression in mouse breast tumors produced by mammary tumor virus-driven Wnt1 signaling. It also blocks carcinogenesis in other Wnt-related tumors at doses that have limited impact on stem cell renewal.

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Suppliers and manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
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₹0.00 /25kg
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₹6.68 /1KG
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