Wnt-C59
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- ₹18830
- Product name: Wnt-C59
- CAS: 1243243-89-1
- MF: C25H21N3O
- MW: 379.45
- EINECS:-0
- MDL Number:MFCD22201167
- Synonyms:Wnt-C59;2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetaMide;C59;Wnt-C59 (C59);4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide;4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide Wnt-c59;Wnt-C59, >=98%;WNT-C59 (C59);WNT C59;C59
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product number5.00496
- Product descriptionPorcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem
- Packaging10MG
- Price₹18830
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 5.00496 | Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem | 10MG | ₹18830 | 2022-06-14 | Buy |
Properties
Melting point :>159°C (dec.)
Boiling point :628.3±55.0 °C(Predicted)
Density :1.198±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)
form :Off-white powder
pka :13.78±0.70(Predicted)
color :Tan
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Boiling point :628.3±55.0 °C(Predicted)
Density :1.198±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)
form :Off-white powder
pka :13.78±0.70(Predicted)
color :Tan
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety Information
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Description
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. Wnt-C59 is a potent inhibitor of PORCN, as measured by prevention of Wnt3A activation (IC50 = 74 pM). As palmitoylation of Wnt is required for its secretion, Wnt-C59 completely blocks Wnt3A secretion into culture media. Wnt-C59 prevents activation of all evaluated Wnt family members. This compound is effective in vivo as well as in vitro. Whether given by intravenous (2.5 mg/kg) or oral administration (5 mg/kg), Wnt-C59 displays a half-life in blood of approximately 1.94 hours, and remains greater than 10-fold above the in vitro IC50 concentration for at least 16 hours after a single oral dose. It blocks the progression of both basal-like and triple-negative breast cancers while downregulating Wnt/β-catenin pathway target genes in mice.More related product prices
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