Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >GSK-3 inhibitors >AZD 1080

AZD 1080

AZD 1080 Structure
CAS No.
612487-72-6
Chemical Name:
AZD 1080
Synonyms
CS-809;AZD1080;AZD 1080;AZD-1080;AZD 1080;AZD-1080;AZD 1080 USP/EP/BP;AZD1080 AZD-1080 GSK-3 Inhibitor;2-Hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile;2-hydroxy-3-[5-(4-morpholinylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile;2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile
CBNumber:
CB72666593
Molecular Formula:
C19H18N4O2
Molecular Weight:
334.37
MOL File:
612487-72-6.mol
Modify Date:
2024/7/2 8:55:16
Request For Quotation

AZD 1080 Properties

Boiling point 594.0±50.0 °C(Predicted)
Density 1.40±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥16.7 mg/mL in DMSO
form solid
pka 8.32±0.50(Predicted)
color Light yellow to orange

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

AZD 1080 Chemical Properties,Uses,Production

Description

The two isoforms of glycogen synthase kinase 3, GSK3α and GSK3β, constitutively phosphorylate and inactivate glycogen synthase, preventing glycogen synthesis. They also phosphorylate proteins that are relevant to Alzheimer’s disease and osteogenesis. AZD 1080 is a potent, brain permeable inhibitor of GSK3α and GSK3β (Kis = 6.9 and 31 nM, respectively). It shows >14-fold selectivity against several kinases, receptors, enzymes, and ion channels. AZD 1080 inhibits tau phosphorylation in cells. It shows good bioavailability after oral administration in vivo, inhibiting hippocampal tau phosphorylation and reversing cognitive deficits induced by the NMDA receptor antagonist (+)-MK-801 . In humans, oral AZD 1080 inhibits GSK3 activity in peripheral blood lymphocytes following an initial delay in response.

AZD 1080 Preparation Products And Raw materials

Raw materials

Preparation Products

AZD 1080 Suppliers

Global( 116)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58

AZD 1080 Spectrum

AZD 1080(612487-72-6)1HNMR

612487-72-6(AZD 1080)Related Search:

Cisplatin SB 415286 ABT 737 Pictilisib AZD-2858
Disulfiram
chevron_left

1of2

chevron_right
AZD 1080 AZD1080 AZD-1080 2-Hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile 2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile 2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile AZD1080 CS-809 AZD 1080;AZD-1080 2-hydroxy-3-[5-(4-morpholinylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile AZD 1080 USP/EP/BP AZD1080 AZD-1080 GSK-3 Inhibitor 612487-72-6 Inhibitors Akt mTOR PI3K