Disulfiram
- CAS No.
- 97-77-8
- Chemical Name:
- Disulfiram
- Synonyms
- DSF;TETD;Disulfuram;disulfane;Tts;Antabuse;TETRAETHYLTHIURAM DISULFIDE;Ttd;TATD;DRAM
- CBNumber:
- CB0476519
- Molecular Formula:
- C10H20N2S4
- Molecular Weight:
- 296.54
- MOL File:
- 97-77-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/29 18:03:56
| Melting point | 69-71 °C (lit.) |
|---|---|
| Boiling point | 117°C |
| Density | 1.27 |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5500 (estimate) |
| Flash point | 117°C/17mm |
| storage temp. | 2-8°C |
| solubility | 0.004g/l |
| pka | 0.86±0.50(Predicted) |
| form | Crystals, Crystalline Powder or Granules |
| color | Light yellow |
| Odor | lt. gray powd., sl. odor |
| Water Solubility | 0.02 g/100 mL |
| Merck | 14,3364 |
| BRN | 1712560 |
| Exposure limits |
ACGIH: TWA 2 mg/m3 NIOSH: TWA 2 mg/m3 |
| Stability | Stable. Incompatible with strong oxidants. |
| InChIKey | AUZONCFQVSMFAP-UHFFFAOYSA-N |
| LogP | 3.6 at 21℃ |
| CAS DataBase Reference | 97-77-8(CAS DataBase Reference) |
| IARC | 3 (Vol. 12, Sup 7) 1987 |
| NIST Chemistry Reference | Disulfiram(97-77-8) |
| EPA Substance Registry System | Disulfiram (97-77-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H373-H410 | |||||||||
| Precautionary statements | P273-P280-P301+P312+P330-P302+P352-P314 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-43-48/22-50/53 | |||||||||
| Safety Statements | 24-37-60-61 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 2 mg/m3 [Precautions should be taken to avoid concurrent exposure to ethylene dibromide.] | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | JO1225000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29303000 | |||||||||
| Toxicity | LD50 orally in rats: 8.6 g/kg (Child, Cramp) | |||||||||
| NFPA 704 |
|
Disulfiram price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 86720 | Tetraethylthiuram disulfide ≥97.0% (S) | 97-77-8 | 50G | ₹2262.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 86720 | Tetraethylthiuram disulfide ≥97.0% (S) | 97-77-8 | 250G | ₹4373.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1690 | Disulfiram Pharmaceutical Secondary Standard; Certified Reference Material | 97-77-8 | 1G | ₹11961.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 86720 | Tetraethylthiuram disulfide ≥97.0% (S) | 97-77-8 | 1KG | ₹13033.3 | 2022-06-14 | Buy |
| TCI Chemicals (India) | B0479 | Tetraethylthiuram Disulfide | 97-77-8 | 25G | ₹2000 | 2022-05-26 | Buy |
Disulfiram Chemical Properties,Uses,Production
Description
Disulfiram was first synthesized in the 1800s to improve the manufacturing process of rubber. A physician working in a rubber factory plant first observed in 1937 that factory workers who were exposed to disulfiram were intolerant to ethanol. In the 1940s, two scientists rediscovered the disulfiram– ethanol effects while researching antiparasitic therapies. This finding eventually led to the approval of the medication to be used as an ethanol deterrent by the Food and Drug Administration in 1951.
Chemical Properties
yellow-white crystals or grey powder
Uses
Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM) that has been indicated for the treatment of alcohol dependence. It also inhibits the copper-dependent enzyme dopamine β-hydroxylase, which prevents the breakdown of dopamine and has been considered as a treatment for cocaine dependence. When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 μM) and 26S proteasome (IC50 = 20 μM) from MDA-MB-0231 breast cancer cells. Because disulfiram targets the ubiquitin-proteasome pathway, it has been investigated as an anti-cancer agent. Furthermore, at 250 nM it has been shown to induce reactive oxygen species, to activate JNK and p38 pathways, and to inhibit NF-κB activity, which suppresses self-renewal in cancer stem cells.
Definition
ChEBI: An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.
General Description
Odorless or almost odorless white or almost white to tan powder. Unpleasant taste with metallic or garlic aftertaste. pH of a solution obtained by shaking 1 g with 30 mL of water is 6 to 8.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Disulfiram is sensitive to light. Disulfiram is incompatible with strong acids, strong oxidizers and nitrosating agents (e.g. N-Nitrosodiphenylamine). .
Hazard
Toxic symptoms when ingested with alcohol; animal teratogen. Vasodilation and nausea. Questionable carcinogen.
Health Hazard
Disulfiram affects the central
nervous system, thyroid, and skin; in combination
with alcohol it causes an “Antabusealcohol”
syndrome.
Small doses of disulfiram reportedly can
cause effects on thyroid iodine uptake and
thyroid gland hypertrophy. It may also
produce dermatitis and acneform rashes.
Fire Hazard
Flash point data for Disulfiram are not available; however, Disulfiram is probably combustible.
Biological Activity
Inhibitor of aldehyde dehydrogenase that displays antialcoholism activity. Shown to reversibly stimulated Ca 2+ -ATPase activity and inhibit V-ATPase (EC 50 = 26 μ M). Also inhibits expression of MMP-2 and MMP-9 and displays anti-invasive activity.
Contact allergens
TETD is a rubber accelerator of the thiuram group, contained in “thiuram mix.” It can cross-react with other thiurams, especially TMTD. TETD is used to aid those trying to break their dependence on alcohol. The disulfiram-alcohol reaction is not allergic but due to the accumulation of toxic levels of acetaldehyde. The implanted drug can, however, lead to local or generalized dermatitis, for example ingested disulfiram, mainly in previously rubber-sensitized patients. As an adjunctive treatment of alcoholism, it caused occupational contact dermatitis in a nurse.
Safety Profile
A human poison by ingestion. An experimental poison by intraperitoneal route. Toxic symptoms when accompanied by ingestion of alcohol. Human systemic effects by ingestion: jaundtce, joint changes. An experimental teratogen. Other experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. See also THIRAM.
Carcinogenicity
In a lifetime carcinogenicity bioassay,
disulfiram was not carcinogenic in either rats
or mice when fed in the diet. The highest
doses were 600 ppm in rats and 2000ppm in
mice.
Increased fetal resorptions, but no teratogenic
effects, were seen in rats exposed at
100mg/kg/day from day 3 of gestation. A weak
genotoxic response was observed in mice
treated in vivo as evidenced by an increase in
sister chromatid exchanges in bone marrow
and spermatogonial cells.9
The 2003 ACGIH threshold limit valuetime-
weighted average (TLV-TWA) is
2mg/m3.
Disulfiram Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SNA HEALTHCARE PVT LTD | +91-8652842416 +91-8652842416 | Mumbai, India | 88 | 58 | Inquiry |
| Yasho Industries Ltd | +91-2262510100 +91-8291955977 | Mumbai, India | 70 | 58 | Inquiry |
| Afton Pharma | +91-9712000202 +91-9712000202 | Gujarat, India | 63 | 58 | Inquiry |
| Solara Active Pharma Sciences Ltd | +91-8046632100 +91-7075706520 | Bangalore, India | 65 | 58 | Inquiry |
| East Coast Organics | +91-9449841944 +91-9449841944 | Tamil Nadu, India | 8 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Raigad Chemicals Pvt Ltd | +91-9029419019 +91-9757110215 | Maharashtra, India | 11 | 58 | Inquiry |
| Rajasthan Antibiotics Ltd | 91-11-1147666111 | New Delhi, India | 11 | 58 | Inquiry |
| Unidrug Innovative Pharma Technologies Ltd | +91-7312533576 +91-7312533324 | Madhya Pradesh, India | 9 | 58 | Inquiry |
| REXIN Laboratories (Redson Group) | +91-9898937773 +91-8866003844 | Gujarat, India | 11 | 58 | Inquiry |
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