Bithionol
- CAS No.
- 97-18-7
- Chemical Name:
- Bithionol
- Synonyms
- Bitin;xl7;d26;XL 7;D 26;tkhsd;Bithin;cp3438;tbp[qr];xl7[qr]
- CBNumber:
- CB5709001
- Molecular Formula:
- C12H6Cl4O2S
- Molecular Weight:
- 356.05
- MOL File:
- 97-18-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/14 15:18:27
| Melting point | 188°C |
|---|---|
| Boiling point | 444.7±45.0 °C(Predicted) |
| Density | 1.61 |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO: soluble20mg/mL, clear |
| pka | 4.82, 10.50(at 25℃) |
| form | powder |
| color | white to beige |
| Water Solubility | <0.1 g/100 mL at 23 ºC |
| Merck | 14,1306 |
| BRN | 2003535 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 97-18-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Bis(2-hydroxy-3,5-dichlorophenyl)sulfide(97-18-7) |
| EPA Substance Registry System | Bithionol (97-18-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | T+,Xn | |||||||||
| Risk Statements | 28-20/21/22 | |||||||||
| Safety Statements | 28-36/37-45-36 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SN0525000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29309090 | |||||||||
| Toxicity | LD50 oral in rat: 7mg/kg | |||||||||
| NFPA 704 |
|
Bithionol price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 31622 | Bithionol VETRANAL?, analytical standard | 97-18-7 | 250MG | ₹5001.15 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T0865 | 2,2'-Thiobis(4,6-dichlorophenol) min. 97.0 % | 97-18-7 | 25G | ₹4100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T0865 | 2,2'-Thiobis(4,6-dichlorophenol) min. 97.0 % | 97-18-7 | 500G | ₹19200 | 2022-05-26 | Buy |
Bithionol Chemical Properties,Uses,Production
Chemical Properties
Bithionol is a white or grayish powder with a slight phenolic odor.
Physical properties
Bithionol is virtually insoluble in water, readily soluble in ethanol, diethyl ether, acetone, glacial acetic acid, and dilute alkalis.
Uses
anthelmintic, antiseptic
Indications
Bithionol (Actamer) is a phenolic derivative whose
mode of action is related to uncoupling of parasitespecific
fumarate reductase–mediated oxidative phosphorylation.
The drug is administered orally and is absorbed
from the intestinal tract. Peak blood levels are achieved in
4 to 8 hours. Excretion is mainly by the kidneys.
Bithionol is used in treatment of F. hepatica infections
and as an alternative to praziquantel in the treatment
of infestation by P. westermani. It is highly active
against the adult worm but exerts no action against the
migratory stages. A second course of treatment is required
for complete cure in 20 to 30% of patients.
Side effects are generally mild and transient; they
include nausea, vomiting, diarrhea, headache, dizziness,
urticaria, and other skin rashes in 50% of patients.
Definition
ChEBI: An aryl sulfide that is diphenyl sulfide in which each phenyl group is substituted at position 2 by hydroxy and at positions 3 and 5 by chlorine. A fungicide and anthelmintic, it was used in various topical drug products for the treatment of liver flukes, ut withdrawn after being shown to be a potent photosensitizer with the potential to cause serious skin disorders.
Production Methods
Bithionol is prepared by reaction of 2,4-dichlorophenol with sulfur dichloride and AlCl3 in carbon disulfide or tetrachloromethane. It is used as a microbicide to protect aqueous functional fluids from biodeterioration and to control algae and slime formation in process water systems.
World Health Organization (WHO)
Bithionol, which has bactericidal and anthelminthic activity, was formerly available in soaps. By the late 1960s use of such preparations had been associated with a risk of photosensitivity reactions and cross-sensitivity with other halogenated disinfectants. This resulted in their withdrawal in the USA. Oral preparations of bithionol remain available for the treatment of paragonimiasis and fascioliasis.
General Description
White or grayish white crystalline powder with a very faint aromatic or phenolic odor.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Bithionol is incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials may generate heat and toxic or flammable gases.
Hazard
Toxic by ingestion.
Health Hazard
ACUTE/CHRONIC HAZARDS: Bithionol is a skin irritant. When heated to decomposition or upon contact with acid or acid fumes, toxic fumes are evolved.
Fire Hazard
Flash point data is not available for Bithionol, but Bithionol is probably combustible.
Mechanism of action
Biothionol is bis-dichlorophenol, and it is structurally similar to hexachlorophene. It is the antihelmintic drug of choice for treating humans infected with Fasciola hepatica. It is an alternative drug to praziquantel that is used for treating pulmonary and cerebral paragonimiasis. The exact mechanism of action is not known, although it seems likely that it inhibits oxidative phosphorylation in Paeagonumus westermani. Synonyms of this drug are actamer, bitin, prevenol, and others.
Clinical Use
2,2’-Thiobis(4,6-dichlorophenol), or bis(2-hydroxy-3,5-dichlorophenyl)sulfide (Lorothidol, Bithin), a chlorinatedbisphenol, was formerly used in soaps and cosmetics for itsantimicrobial properties but was removed from the marketfor topical use because of reports of contact photodermatitis.Bithionol has useful anthelmintic properties and hasbeen used as a fasciolicide and taeniacide. It is still consideredthe agent of choice for the treatment of infestationscaused by the liver fluke Fasciola hepatica and the lungfluke Paragonimus westermani. Niclosamide is believed tobe superior to it for the treatment of tapeworm infestations.
Potential Exposure
It is used as a surfactant-formulated antimicrobial against bacteria, molds and yeast. It is proposed as an agricultural fungicide. Other uses include deodorant, germicide, fungistat, and in the manufacture of pharmaceuticals. It is no longer allowed to be used in cosmetics. A food additive in feed and drinking water of animals. Also a food additive permitted in food for human consumption.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Bithionol Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29896 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
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