Tetramethylthiuram Disulfide
- CAS No.
- 137-26-8
- Chemical Name:
- Tetramethylthiuram Disulfide
- Synonyms
- TMTD;THIRAM;1,1’-dithiobis(n,n-dimethylthio-formamid;THIURAM;TETRAMETHYLTHIURAM DISULPHIDE;Tetramethylthiuram;TNTD;METHYL TUADS;AcceleratorTMTD;TIMTEC-BB SBB000804
- CBNumber:
- CB9218792
- Molecular Formula:
- C6H12N2S4
- Molecular Weight:
- 240.43
- MOL File:
- 137-26-8.mol
- Modify Date:
- 2024/2/29 13:46:39
| Melting point | 156-158 °C(lit.) |
|---|---|
| Boiling point | 129 °C (20 mmHg) |
| Density | 1.43 |
| vapor pressure | 8 x 10-6 mmHg at 20 °C (NIOSH, 1997) |
| refractive index | 1.5500 (estimate) |
| Flash point | 89°C |
| storage temp. | under inert gas (argon) |
| solubility | 0.0184g/l |
| form | solid |
| pka | 0.87±0.50(Predicted) |
| Water Solubility | 16.5 mg/L (20 ºC) |
| Merck | 14,9371 |
| BRN | 1725821 |
| Exposure limits | NIOSH REL: TWA 0.5 mg/m3, IDLH 100 mg/m3; OSHA PEL: 0.5 mg/m3; ACGIH TLV: TWA 5 mg/m3. |
| InChIKey | KUAZQDVKQLNFPE-UHFFFAOYSA-N |
| LogP | 1.730 |
| CAS DataBase Reference | 137-26-8(CAS DataBase Reference) |
| IARC | 3 (Vol. Sup 7, 53) 1991 |
| NIST Chemistry Reference | Thiram(137-26-8) |
| EPA Substance Registry System | Thiram (137-26-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H332-H315-H317-H319-H373-H410 | |||||||||
| Precautionary statements | P273-P280-P301+P312-P302+P352-P304+P340+P312-P314 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 20/22-36/38-43-48/22-50/53 | |||||||||
| Safety Statements | 26-36/37-60-61 | |||||||||
| RIDADR | UN 2771/2811 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 5 mg/m3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | JO1400000 | |||||||||
| Autoignition Temperature | 316 °F | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29303000 | |||||||||
| Toxicity | LD50 orally in rats: 640 mg/kg (Gaines) | |||||||||
| IDLA | 100 mg/m3 | |||||||||
| NFPA 704 |
|
Tetramethylthiuram Disulfide price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T24201 | Tetramethylthiuram disulfide 97% | 137-26-8 | 5G | ₹1948.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T24201 | Tetramethylthiuram disulfide 97% | 137-26-8 | 100G | ₹2803.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 45689 | Thiram PESTANAL?, analytical standard | 137-26-8 | 250MG | ₹6332.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 43966 | Thiram certified reference material, TraceCERT? | 137-26-8 | 50MG | ₹13639.5 | 2022-06-14 | Buy |
| ALFA India | ALF-B20063-36 | Tetramethylthiuram disulfide, 97% | 137-26-8 | 500g | ₹5460 | 2022-05-26 | Buy |
Tetramethylthiuram Disulfide Chemical Properties,Uses,Production
Description
Tetramethylthiuram disulfide is a rubber chemieal, an accelerator of vulcanization. It represents the most commonly positive allergen contained in the "thiuram mix". The most frequent occupational categories are the metal industry, homemakers, health services and laboratories, building industries, and shoemakers.
Chemical Properties
white to almost white powder
Physical properties
Colorless to white to cream-colored crystals. May darken on exposure to air or light.
Uses
Tetramethylthiuram disulfide is used as fungicide; bacteriostat; pesticide; rubber vulcanization accelerator; scabicide; seed disinfectant; animal repellent; insecticide; lube-oil additive; wood preservative; in antiseptic sprays; in the blending of lubrieant oils; used against Botrytis, rusts and downy mildews; seed dressing against "damping off' and verticillium wilt; ethanol antagonist and deterrent in mixtures of the methyl, ethyl, propyl, and butyl derivatives; antioxidant in polyolefin plastics; peptizing agent in polysulphide elastomers; in soaps and rodent repellents; nut, fruit, and mushroom disinfectant.
Definition
ChEBI: An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.
General Description
A liquid solution of a white crystalline solid. Primary hazard is to the environment. Immediate steps should be taken to limit spread to the environment. Easily penetrates the soil to contaminates groundwater and waterways.
Air & Water Reactions
Insoluble in water. Decomposes in acidic media to give toxic products. Decomposes to an extent on prolonged exposure to heat, air or moisture.
Reactivity Profile
TMTD is incompatible with oxidizing materials and strong acids. Also incompatible with strong alkalis and nitrating agents .
Hazard
Toxic by ingestion and inhalation, irritant to skin and eyes. Body weight and hematologic effects. Questionable carcinogen.
Health Hazard
Inhalation of dust may cause respiratory irritation. Liquid irritates eyes and skin and may cause allergic eczema in sensitive individuals. Ingestion causes nausea, vomiting, and diarrhea, all of which may be persistent; paralysis may develop.
Fire Hazard
Special Hazards of Combustion Products: Toxic and irritating oxides of sulfur are formed. Carbon disulfide may be formed from unburned material.
Agricultural Uses
Fungicide, Rodenticide: Thiram is used as a fungicide to prevent crop damage in the field and to prevent crops from deterioration in storage or transport. Thiram is also used as a seed, nut, fruit, and mushroom disinfectant from a variety of fungal diseases. In addition, it is used as an animal repellent to protect fruit trees and ornamentals from damage by rabbits, rodents, and deer. Thiram has been used in the treatment of human scabies, as a sun screen, and as a bactericide applied directly to the skin or incorporated into soap. Thiram is used as a rubber accelerator and vulcanizer and as a bacteriostat for edible oils and fats. It is also used as a rodent repellent, wood preservative, and may be used in the blending of lubricant oils. Registered for use in EU countries. Registered for use in the U.S.
Contact allergens
TITD is a rubber vulcanization accelerator
Safety Profile
Poison by ingestion and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic and teratogenic data. Other experimental reproductive effects. Mutation data reported, Affects human pulmonary system. A rmld allergen and irritant. Acute poisoning in experimental animals produced liver, hdney, and brain damage. Dangerous in a fire; see NITROGEN MONOXIDE and SULFUR DIOXIDE.
Potential Exposure
Thiram is a dithiocarbamate. Some thiurams have been used as rubber components: thiram is used as a rubber accelerator and vulcanizer; a seed, nut, fruit, and mushroom disinfectant; a bacteriostat for edible oils and fats; and as an ingredient in suntan and antiseptic sprays and soaps. It is also used as a fungicide, rodent repellent; wood preservative; and may be used in the blending of lubricant oils.
Carcinogenicity
Thiram also was not carcinogenic in rats
by gavage or in mice by single subcutaneous
injection. In skin painting studies in mice
thiram had tumor-initiating and -promoting
activity but was not a complete carcinogen.
Thiram was genotoxic to insects, plants,
fungi, and bacteria: it induced sister chromatid
exchange and unscheduled DNA synthesis in
cultured human cells. Despite established
genotoxicity in vitro, it showed no clastogenic
and/or aneugenic activity in vivo after oral
administration to mice at the maximum tolerated
dose.
Metabolic pathway
Dialkyldithiocarbamates chelate copper and inhibit pyruvate dehydrogenase. It is likely that the mode of action of chelators is principally through their effect on lipoamide containing dehydrogenases (Corbett et al., 1984). Thiram generates dimethyldithiocarbamic acid by being cleaved in acidic conditions and in biological media. The acid is conjugated with glucose and alanine in plants and with glucuronic acid in mammals. Dimethyldithiocarbamic acid is further degraded to dimethylamine and CS2. An extensive review of the properties of dithiocarbamate pesticides was published by the World Health Organisation (WHO, 1988) from which much of the following information is taken.
Shipping
UN2771 Thiocarbamate pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Crystallise thiram (three times) from boiling CHCl3, then recrystallise it from boiling CHCl3 by adding EtOH dropwise to initiate crystallisation, and allow it to cool. Finally it is precipitated from cold CHCl3 by adding EtOH (which retains the monosulfide in solution). [Ferington & Tobolsky J Am Chem Soc 77 4510 1955, Beilstein 4 IV 242.]
Incompatibilities
Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine,fluorine, etc.); contact may cause fires or explosions. Keep away from strong alkaline materials, strong acids, strong bases and nitrating agents.
Waste Disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Thiram can be dissolved in alcohol or other flammable solvent and burned in an incinerator with an afterburner and scrubber.
Tetramethylthiuram Disulfide Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| India Pesticides Limited | +91-5222653602 +91-5222653602 | Uttar Pradesh, India | 12 | 58 | Inquiry |
| Raigad Chemicals Pvt Ltd | +91-9029419019 +91-9757110215 | Maharashtra, India | 11 | 58 | Inquiry |
| Rajasthan Antibiotics Ltd | 91-11-1147666111 | New Delhi, India | 11 | 58 | Inquiry |
| Super Crop Safe Limited | +91-9726022444 +91-9824169514 | Gujarat, India | 38 | 58 | Inquiry |
| Shree Vallabh Chemicals | +91-8849453471 +91-9975490440 | Gujarat, India | 43 | 58 | Inquiry |
| Munjal Agro | 08046056759 | Delhi, India | 3 | 58 | Inquiry |
| Thakar Dass & Company Private Limited | 08048361356Ext 322 | Haryana, India | 4 | 58 | Inquiry |
| GSP Crop Science Private Limited | 07926466580 | Ahmedabad, India | 13 | 58 | Inquiry |
| Parijat Industries India Private Limited | 08048372460Ext 265 | Delhi, India | 19 | 58 | Inquiry |
| Sheri Trading Corporation | 07942559426 | Delhi, India | 6 | 58 | Inquiry |
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