1H-INDOLE-3-ACETICACID,1-(3-CHLOROBENZOYL)-5-METHOXY-2-METHYL

1H-INDOLE-3-ACETICACID,1-(3-CHLOROBENZOYL)-5-METHOXY-2-METHYL Structure
CAS No.
807614-94-4
Chemical Name:
1H-INDOLE-3-ACETICACID,1-(3-CHLOROBENZOYL)-5-METHOXY-2-METHYL
Synonyms
Indomethacin Imp E;Indometacin Impurity 13;Indapamide EP Impurity E;Indometacin EP Impurity E;Indomethacin EP Impurity E;Indomethacin EP Impurity 13;4-Dechloro-3-chloroindomethacin;Indomethacin (Indometacin) EP Impurity E;Indomethacin Impurity 5(Indomethacin EP Impurity E);1H-INDOLE-3-ACETICACID,1-(3-CHLOROBENZOYL)-5-METHOXY-2-METHYL
CBNumber:
CB72712887
Molecular Formula:
C19H16ClNO4
Molecular Weight:
357.79
MOL File:
807614-94-4.mol
Modify Date:
2023/4/23 13:52:06

1H-INDOLE-3-ACETICACID,1-(3-CHLOROBENZOYL)-5-METHOXY-2-METHYL Properties

Melting point 109 - 112oC
Boiling point 500.6±50.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Chloroform (Slightly), Methanol (Slightly)
pka 3.96±0.30(Predicted)
form Solid
color Pale Pink

1H-INDOLE-3-ACETICACID,1-(3-CHLOROBENZOYL)-5-METHOXY-2-METHYL Chemical Properties,Uses,Production

Uses

4-Dechloro-3-chloroindomethacin is an impurity of Indomethacin (I641000) which inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO).

1H-INDOLE-3-ACETICACID,1-(3-CHLOROBENZOYL)-5-METHOXY-2-METHYL Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-INDOLE-3-ACETICACID,1-(3-CHLOROBENZOYL)-5-METHOXY-2-METHYL Indometacin Impurity 13 4-Dechloro-3-chloroindomethacin Indomethacin Impurity 5(Indomethacin EP Impurity E) Indomethacin EP Impurity 13 Indomethacin impurity 4/Indomethacin EP impurity E/2-(1-(3-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid Indomethacin Imp E 2-[1-(3-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid Indomethacin EP Impurity E Indometacin EP Impurity E Indapamide EP Impurity E 2-(1-(3-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid Indomethacin (Indometacin) EP Impurity E [1-(3-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic Acid 2-(1-(3-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid (Indomethacin Impurity) 807614-94-4