Oxymetholone
- CAS No.
- 434-07-1
- Chemical Name:
- Oxymetholone
- Synonyms
- OXYCLOZANIDE;Anadrol;Anapolon;OxyMetholon;oxymethalone;OxyMetholone (Anadrol);anapalon;Methabol;Oximetholone;oxyMethelone
- CBNumber:
- CB7353507
- Molecular Formula:
- C21H32O3
- Molecular Weight:
- 332.48
- MOL File:
- 434-07-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 17:49:17
| Melting point | 172-180°C |
|---|---|
| alpha | 34 º |
| Boiling point | 409.59°C (rough estimate) |
| Density | 1.0834 (rough estimate) |
| refractive index | 38 ° (C=1, CHCl3) |
| storage temp. | 2-8°C |
| solubility | H2O: ≤0.5 mg/mL |
| form | solid |
| pka | 5.28±0.70(Predicted) |
| color | white to light yellow |
| Water Solubility | <0.1 g/100 mL at 23 ºC |
| Merck | 6967 |
| Stability | Stability May be light sensitive. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | ICMWWNHDUZJFDW-CCTJMHFWSA-N |
| CAS DataBase Reference | 434-07-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Oxymetholone(434-07-1) |
| EPA Substance Registry System | Oxymetholone (434-07-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H351-H361 | |||||||||
| Precautionary statements | P201-P308+P313 | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 40-63 | |||||||||
| Safety Statements | 53-22-26-36/37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BV8060000 | |||||||||
| HS Code | 29372900 | |||||||||
| Toxicity | TDLo orl-hmn: 46 mg/kg/14W-I:LIV JAMAAP 240,243,78 | |||||||||
| NFPA 704 |
|
Oxymetholone Chemical Properties,Uses,Production
Description
Oxymetholone is a synthetic, orally active anabolic-androgenic steroid (AAS) and 17α-methylated derivative of dihydrotestosterone (DHT). It is mainly used for the treatment of osteroporosis and anemia (low red blood cell count). It can also stimulate the muscle growth in malnourished or underdeveloped patients. It also has the potential to treat the HIV wasting syndrome. Oxymetholone can also lead to an even buildup in strength, which is its secondary characteristics, making it an excellent steroid to be coupled with other anabolic steroids to yield synergetic effect.
Chemical Properties
Oxymetholone is an odorless white to pale yellow crystalline solid or powder. Insoluble in water, easily soluble in chloroform, soluble in dioxane, vegetable oil, slightly soluble in ethanol and ether. It is sensitive to light (Akron 2009). It is structurally related to the male hormone testosterone (IARC 1977, NTP 1999).
Uses
Oxymetholone is used in treatment of myelofibrosis and myelosuppression. This drug can provoke bone marrow cells and rise the blood cells in the peripheral blood vessels. It has been approved by the US Food and Drug Administration for the treatment of anemia caused by deficient red cell production. It is effective in catabolic states, replacement of male sex steroids in men who have androgen deficiency, and in eugonadal male and female patients with acquired immunodeficiency syndrome-associated wasting.
Definition
ChEBI: Oxymetholone is a 3-oxo-5alpha- steroid that is 4,5alpha-dihydrotestosterone which is substituted by a hydroxymethylidene group at position 2 and by a methyl group at the 17alpha position. A synthetic androgen, it was mainly used for the treatment of anaemias until being replaced by treatments with fewer side effects. It has a role as an anabolic agent, an androgen and an anti-anaemic agent. It is a 17beta-hydroxy steroid, an enone, a tertiary alcohol, an enol, an anabolic androgenic steroid and a 3-oxo-5alpha-steroid.
General Description
Oxymetholone is an odorless white to creamy white crystalline powder. It is approved for the treatment of various anemias.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Oxymetholone may be sensitive to light.
Health Hazard
SYMPTOMS: Symptoms of exposure to Oxymetholone may include cholestatic jaundice, hepatocellular neoplasms and peliosis hepatitis. Prepubertal exposure may cause phallic enlargement and increased frequency of erection. Postpubertal exposure may cause inhibition of testicular function, testicular atrophy, oligospermia, impotence, chronic priapism, epididymitis, bladder irritability, clitoral enlargement, menstrual irregularities, increased or decreased libido, excitation, insomnia, nausea, vomiting, diarrhea, leukemia, gynecomastia, deepening of the voice in women, hirsutism and male-pattern baldness in women, acne, edema, retention of serum electrolytes and decreased glucose tolerance. It may also cause higher risk of developing liver cell tumors. Other symptoms include abnormal liver function tests, salt and water retention and masculinization, particularly of the female fetus.
Fire Hazard
Flash point data for Oxymetholone are not available. Oxymetholone is probably combustible.
Safety Profile
Confirmed human carcinogen producing liver tumors. Human systemic effects by ingestion: impaired liver function. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also TESTOSTERONE.
Potential Exposure
Oxymetholone is a controlled substance (US), hormone and a systemic anabolic steroid.
Carcinogenicity
Oxymetholone is reasonably anticipated to be a human carcinogenbased on limited evidence of carcinogenicity in humans.
Environmental Fate
Oxymetholone may release into the environment through various waste streams. If released to air, oxymetholone does not absorb light at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, oxymetholone is expected to have moderate mobility. Occupational exposure to oxymetholone may occur via dermal contact with this compound at workplaces where oxymetholone is produced. It can be overused intentionally in humans as a performance enhancement drug in athletes.
Shipping
UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides. May be combustible and light-sensitive.
Waste Disposal
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, doublebagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| Horster Biotek Pvt Ltd | +91-7359657360 +91-9898127219 | Gujarat, India | 58 | 58 | Inquiry |
| Swati Spentose Pvt Ltd | +91-2261505232 +91-2261505232 | Maharashtra, India | 44 | 58 | Inquiry |
| A Mart | 07942557623 | Mumbai, India | 4 | 58 | Inquiry |
| Fitness Hub | 08047622875 | Punjab, India | 4 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Dac Pharma Merchant | 91-120-4279616 | Uttar Pradesh, India | 47 | 58 | Inquiry |
| Indogulf Group | 91-22-23455220 | Maharashtra, India | 249 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Manav Drugs Pvt. Ltd. | 91-22-65305000 | Maharashtra, India | 78 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Gonane Pharma | 58 |
| Horster Biotek Pvt Ltd | 58 |
| Swati Spentose Pvt Ltd | 58 |
| A Mart | 58 |
| Fitness Hub | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Dac Pharma Merchant | 58 |
| Indogulf Group | 58 |
| Pharma Affiliates | 58 |
| Manav Drugs Pvt. Ltd. | 58 |
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