2-Acetylphenothiazine
- CAS No.
- 6631-94-3
- Chemical Name:
- 2-Acetylphenothiazine
- Synonyms
- 2-APT;ML 171;2-Acetylphenothiazin;2-ACETYLPHENOTHIAZINE;NOX1 Inhibitor, ML171;LABOTEST-BB LT00012652;2-Acetyl-10H-phenothiazine;2-Acetylphenothiazine(ML171);methyl phenothiazin-2-yl ketone;Ethanone, 1-(10H-phenothiazin-2-yl)-
- CBNumber:
- CB7368424
- Molecular Formula:
- C14H11NOS
- Molecular Weight:
- 241.31
- MOL File:
- 6631-94-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:34
| Melting point | 180-185 °C (lit.) |
|---|---|
| Boiling point | 455.7±34.0 °C(Predicted) |
| Density | 1.249±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | -2.45±0.20(Predicted) |
| form | Dark yellow-orange powder |
| color | Yellow to Dark Orange |
| λmax | 244nm(MeOH)(lit.) |
| CAS DataBase Reference | 6631-94-3(CAS DataBase Reference) |
2-Acetylphenothiazine price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 492002 | NOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem The NOX1 Inhibitor, ML171, also referenced under CAS 6631-94-3, controls the biological activity of NOX1. | 6631-94-3 | 10MG | ₹5880 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 175226 | 2-Acetylphenothiazine 95% | 6631-94-3 | 25G | ₹9233.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 175226 | 2-Acetylphenothiazine 95% | 6631-94-3 | 100G | ₹20318.53 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A2815 | 2-Acetylphenothiazine min. 98.0 % | 6631-94-3 | 5G | ₹6400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A2815 | 2-Acetylphenothiazine min. 98.0 % | 6631-94-3 | 25G | ₹27800 | 2022-05-26 | Buy |
2-Acetylphenothiazine Chemical Properties,Uses,Production
Description
2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC50 value of 0.129 μM. It does not affect xanthine oxidase-dependent or mitochondrial ROS generation. 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells. It also abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM), preventing platelet aggregation and thrombus formation. 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1. 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 μM.
Chemical Properties
Yellow white or green crystalline powder
Uses
2-Acetylphenothiazine is a potent and selective NADPH oxidase 1 (NOX1) inhibitor that blocks NOX1-dependent ROS generation. 2-Acetylphenothiazine has been shown to inhibit SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.
2-Acetylphenothiazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANUPAM RASAYAN INDIA LTD. | +91-261239899195 +91-261239899195 | Gujarat, India | 27 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Parad Corporation Pvt Ltd | 91-2662-244460 | Gujarat, India | 31 | 58 | Inquiry |
| Alchymars ICM SM Private Limited | 91-44-24331901 | Tamil Nadu, India | 17 | 58 | Inquiry |
| ZCL Chemicals Limited | 08045849942Ext 277 | Gujarat, India | 15 | 58 | Inquiry |
| Zandu Chemicals Limited | +91 22 2430 7021 | Mumbai, India | 19 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18648 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
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