ATTAPULGITE
- CAS No.
- 12174-11-7
- Chemical Name:
- ATTAPULGITE
- Synonyms
- Palygorskite;attagel50;Attapulgitee;FULLERS EARTH;x250;rvm-fg;zeogel;DILUEX;Attagel;attasorb
- CBNumber:
- CB7382453
- Molecular Formula:
- 2Al.3Mg.6O3Si
- Molecular Weight:
- 583.377
- MOL File:
- 12174-11-7.mol
- Modify Date:
- 2023/11/28 16:31:43
| Density | 2.2 g/cm3 |
|---|---|
| color | White or gray monoclinic or orthorhombic crystals |
| Dielectric constant | 1.8（Ambient） |
| Stability | Stable. |
| IARC | 2B (Vol. 68) 1997, 3 (Vol. 68) 1997 |
| EPA Substance Registry System | Attapulgite (12174-11-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H351 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
| Toxicity | TCLo ihl-rat: 10 mg/m3/6H/13W-I:ETA BJIMAG 44,749,87 |
ATTAPULGITE Chemical Properties,Uses,Production
Chemical Properties
Attapulgite occurs as a light cream colored, very fine powder. Particle size ranges depend on the grade and manufacturer.
Uses
Worldwide attapulgite production in 1983 was estimated at about 1.1 million tons, of which 84% came from the United States. The primary use of attapulgite is as an animal waste absorbent (cat litter). Other important uses of attapulgite in the United States are as a component of drilling muds, as oil and grease absorbents, and in fertilizer and pesticide formulations.
Production Methods
Attapulgite occurs naturally as the mineral palygorskite.
Definition
A hydrated aluminum-magnesium silicate, the chief ingredient of fuller’s earth.
Hazard
Possible carcinogen.
Pharmaceutical Applications
Attapulgite is widely used as an adsorbent in solid dosage forms. Colloidal clays (such as attapulgite) absorb considerable amounts of water to form gels and in concentrations of 2–5% w/v usually form oil-in-water emulsions. Activated attapulgite, which is attapulgite that has been carefully heated to increase its absorptive capacity, is used therapeutically as an adjunct in the management of diarrhea.
Safety Profile
Suspected carcinogen with experimental neoplastigenic and tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety
Attapulgite is widely used in pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material. It is not absorbed following oral administration. In oral preparations, activated attapulgite up to 9 g is used in daily divided doses as an adjunct in the management of diarrhea.
storage
Attapulgite can adsorb water. It should be stored in an airtight container in a cool, dry, location.
Incompatibilities
Attapulgite may decrease the bioavailability of some drugs such as loperamide and riboflavin. Oxidation of hydrocortisone is increased in the presence of attapulgite.
Regulatory Status
Included in nonparenteral medicines licensed in a number of countries worldwide including the UK and USA.
ATTAPULGITE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vardhaman P Golechha | 9704422000 | Telangana, India | 294 | 58 | Inquiry |
| Otto Chemie Pvt Ltd | +91-2222070099 +91-2266382599 | Maharashtra, India | 429 | 58 | Inquiry |
| Global Drilling Fluids and Chemicals Limited | +91-9899836400 +91-9810270611 | Haryana, India | 22 | 58 | Inquiry |
| Sri Chemicals | +91-4426207575 +91-4442127722 | Tamil Nadu, India | 21 | 58 | Inquiry |
| Manek Minerals | +91-2832240199 +91-2832240699 | Gujarat, India | 10 | 58 | Inquiry |
| 20 Microns Limited | +91-2652321534 +91-9099913617 | Gujarat, India | 19 | 58 | Inquiry |
| Cutch Oil And Allied Industries Pvt Ltd | +91-7575085198 +91-7575085198 | Maharashtra, India | 4 | 58 | Inquiry |
| Ennor Muds and Chemicals | +91-8754442175 +91-9840477722 | Tamil Nadu, India | 26 | 58 | Inquiry |
| Prakash Chemicals International Private Limited | 91-265-6126197 | New Delhi, India | 204 | 58 | Inquiry |
| Navin Minerals | 08048371615Ext 252 | Gujarat, India | 1 | 58 | Inquiry |
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