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SCOULERIN

SCOULERIN Structure
CAS No.
6451-73-6
Chemical Name:
SCOULERIN
Synonyms
SCOULERIN;Scoreline;l-skoulerine;l-scoulerine;SCOULERIN(SH);Alkaloid HF-1;SCOULERIN(RG);(-)-scoulerine;(-)-Scoulerine;2,9-DIOXY-3,10-DIMETHOXYBERBINE
CBNumber:
CB7382903
Molecular Formula:
C19H21NO4
Molecular Weight:
327.37
MOL File:
6451-73-6.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:16
Request For Quotation

SCOULERIN Properties

Melting point 192°C
Boiling point 503.3±50.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form A crystalline solid
pka 9.88±0.20(Predicted)
color Off-white to pink

SCOULERIN Chemical Properties,Uses,Production

Description

This form of the alkaloid is more widespread than the d-form, occurring in Corydalis caseana, C. micrantha, C. montana, C. scouleri, C. sibirica and Papaver somniferum. It has [α]26D - 318° (c 0.41, MeOH) or - 289° (c 0.62, MeOH). It forms pale grey needles when crystallized from MeOH. The hydrochloride has m.p. 268-9°C; the picrate, m.p. 206°C (dec.) and the diethyl ether, m.p. 155°C. The oxidation products are the same as for the preceding base.

Chemical Properties

Off-White to Pale Pink Solid

Uses

(S)-Scoulerine is an alkaloid found in the opium poppy. (S)-Scoulerine acts as an antagonist at the α2-adrenoceptor, α1D-adrenoceptor and 5-HT receptor.

Definition

ChEBI: A berberine alkaloid isolated from Corydalis saxicola.

References

Manske., Can. J. Res., 14B, 347, 354 (1936)
Manske., ibid, 17B, 57 (1939)
Manske., ibid, 18B, 414 (1940)
Manske., ibid, 20B, 49 (1942)
Brochmann-Hanssen, Nielsen., Tetrahedron Lett., 2261 (1966)
Synthesis:
Kametani., Japanese Patent, 70, 37,976, 10 December 1970

SCOULERIN Preparation Products And Raw materials

Raw materials

Preparation Products

SCOULERIN Suppliers

Global( 91)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Chengdu Biopurify Phytochemicals Ltd. +86-28-82633860 +86-18080483897 China 3424 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Labnetwork lnc. +86-27-50766799 +8618062016861 China 19994 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
ABCR GmbH & CO. KG 49 721 95061 0 Germany 6846 75 Inquiry
BioBioPha Co., Ltd. 0871-65217109 CHINA 6464 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9282 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Chengdu Biopurify Phytochemicals Ltd. 58
career henan chemical co 58
Labnetwork lnc. 58
TargetMol Chemicals Inc. 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58
ABCR GmbH & CO. KG 75
BioBioPha Co., Ltd. 58
RD International Technology Co., Limited 58

SCOULERIN Spectrum

SCOULERIN(6451-73-6)1HNMR

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SCOULERIN SCOULERIN(SH) (13aS)-5,8,13,13a-tTtrahydro-3,10-diMethoxy-6H-dibenzo[a,g]quinolizine-2,9-diol (S)-5,8,13,13a-Tetrahydro-3,10-diMethoxy-6H-Dibenzo[a,g]quinolizine-2,9-diol Alkaloid HF 1, froM HunneMannia fuMariaefolia (-)-scoulerine 3,10-dimethoxy-13a-alpha-berbine-2,9-diol 3,10-dimethoxy-13a-alpha-berbine-9-diol g)quinolizine-2,9-diol,5,8,13,13a-tetrahydro-3,10-dimethoxy-6h-dibenzo(( l-scoulerine l-skoulerine 2,9-DIOXY-3,10-DIMETHOXYBERBINE (13aR)-5,8,13,13a-Tetrahydro-3,10-dimethoxy-6H-dibenzo[a,g]quinolizine-2,9-diol [13aR,(+)]-5,8,13,13aβ-Tetrahydro-3,10-dimethoxy-6H-dibenzo[a,g]quinolizine-2,9-diol 3,10-Dimethoxy-13aα-berbine-2,9-diol Alkaloid HF-1 SCOULERIN(RG) 6H-Dibenzo[a,g]quinolizine-2,9-diol, 5,8,13,13a-tetrahydro-3,10-dimethoxy-, (13aS)- Scoreline (13aS)-3,10-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,9-diol (S)-3,10-Dimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline-2,9-diol proliferation,Inhibitor,cancer,Beta-secretase,Scoulerine,Apoptosis,inhibit,microtubule,cycle,β-Secretase,Microtubule/Tubulin,leukemic,BACE,cells,division,mitotic,Discretamine (-)-Scoulerine 6451-73-6 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Alkaloids