VOACANGINE

CAS No.: 510-22-5

Chemical Name:: VOACANGINE

Synonyms: VOACANGINE;(-)-Voacangine;Carbomethoxyibogaine;12-Methoxyibogamine-18-carboxylic acid methyl ester;Ibogamine-18-carboxylic acid, 12-methoxy-, methyl ester

CBNumber:: CB7433742

Molecular Formula:: C22H28N2O3

Molecular Weight:: 368.47

MOL File:: 510-22-5.mol

Modify Date:: 2024/7/2 8:55:16

Request For Quotation

VOACANGINE Properties

Melting point	223-224℃ (dec.)
Density	1.25±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.	Store at -20°C,protect from light
solubility	DMF: 16 mg/ml; DMSO: 16 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.33 mg/ml
form	A crystalline solid
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H312-H332

Precautionary statements

P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501

NFPA 704

	0
3		0

VOACANGINE Chemical Properties,Uses,Production

Description

This alkaloid is of widespread occurrence, being found in Stemmadenia species and also is Vocanga africana, v. dregii and V. obtusa. It forms colourless needles when crystallized from MeOH and has [0'10 - 42° (c 1.0, CHCI3). It sublimes under vacuum at 135°CjO.01 mm and is readily soluble in CHC13 or Me2CO, but only sparingly so in EtOH or MeOH. Hydrolysis with KOH followed by acidification with HCl yields Ibogaine (q.v.).

Uses

(-)-Voacangine is a bisindole alkaloid with ether-?a-?go-?go-?related gene channel blocker activity in vitro. hERG channel blocker.

References

lanot, Goutarel., Compt. rend., 241,986 (1955) Stauffacher, Seebeck., Helv. Chim. Acta, 41,169 (1958) Watts, Collera, Sandoval., Tetrahedron, 2, 173 (1958) Schuler, Verbeck, Warren.,J. Chern. Soc., 4776 (1958) Bartlett, Dickel, Taylor.,J. Amer. Chern. Soc., 80, 126 (1958) Renner, Prins, Stoll., Helv. Chim. Acta, 42,1572 (1959) Budzikiewicz etal., Bull. Soc. Chim. Fr., 1899 (1963)

VOACANGINE Preparation Products And Raw materials

Raw materials

Preparation Products

VOACANGINE Suppliers

Global( 56)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177; +8617531190177	China	5873	58	Inquiry
Hebei Kangcang new material Technology Co., LTD	+8615713292910	China	341	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21667	55	Inquiry
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	China	3000	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	China	4088	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33350	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Kangcang new material Technology Co., LTD	58
Henan Tianfu Chemical Co.,Ltd.	55
Shaanxi Pioneer Biotech Co., Ltd .	58
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58

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VOACANGINE 12-Methoxyibogamine-18-carboxylic acid methyl ester Carbomethoxyibogaine Ibogamine-18-carboxylic acid, 12-methoxy-, methyl ester (-)-Voacangine 510-22-5