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DIMETHYLPHOSPHINE OXIDE

CAS No.: 7211-39-4

Chemical Name:: DIMETHYLPHOSPHINE OXIDE

Synonyms: methylphosphonoylmethane;Methylphosphinoylmethane;Einecs 230-591-2;Dimethylphosphinoxid;Dimethyl-Oxophosphonium;DIMETHYLPHOSPHINE OXIDE;imethyl(oxo)phosphanium;dimethyl(oxo)phosphanium;DIMETHYLPHOSPHINOUS ACID;Keto-Dimethyl-Phosphonium

CBNumber:: CB7447743

Molecular Formula:: C2H7OP

Molecular Weight:: 78.05

MOL File:: 7211-39-4.mol

MSDS File:: SDS

Modify Date:: 2024/9/5 10:00:14

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DIMETHYLPHOSPHINE OXIDE Properties

Boiling point	65-67 °C(Press: 6 Torr)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	liquid
color	white solid to light yellow
Sensitive	air sensitive
InChI	InChI=1S/C2H7OP/c1-4(2)3/h4H,1-2H3
InChIKey	HGDIHUZVQPKSMO-UHFFFAOYSA-N
SMILES	P(=O)(C)C

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H319-H335-H315
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501

DIMETHYLPHOSPHINE OXIDE Chemical Properties,Uses,Production

Description

Dimethylphosphine oxide is an organophosphorus compound. It can be used for the preparation of triacrylphosphine oxide. It can be used as an asymmetric catalyst. In addition, it can be used for the preparation of alkenyldiphenylphosphine oxides, and Horner-Witting reagents. In addition, it is also a kind of capping ligand in organic chemistry.

Chemical Properties

Dimethylphosphine oxide is a colorless liquid that soluble in polar organic solvents.It exists as the phosphine oxide, not the hydroxy tautomer.

Uses

Dimethylphosphine Oxide is used in preparation of substituted piperazine derivatives as DGKα/DGKζ inhibitors for the treatment of viral infections and cancer. It is also used as an organic synthetic raw material for the preparation of (α-aminoalkyl)dimethylphosphine oxide enantiomers. Asymmetric synthesis of α-amino-α-polyfluoroalkyl dimethylphosphine oxides was accomplished through diastereoselective addition of dimethylphosphine oxide to enantiomeric Ellman's aldimines, RFCH=NS(O)tert-Bu (RF=CF3, CHF2, PhCF2).

Application

Dimethylphosphine oxide (DMPO) is a hydrogen bonding receptor that can be used to prepare ALK inhibitor compounds (WX-0593) containing DMPO molecules. The results of enzyme assay experiments showed that WX-0593 has high activity against wild-type and mutant ALK, and also inhibits ROS1WT in Ba/F3 cell line very well. In addition, WX-0593 is currently undergoing a phase I/II trial in ALK-positive NSCLC and is expected to be used for the treatment of ROS1-positive NSCLC.

Reactions

Chlorination gives dimethylphosphoryl chloride. It undergoes hydroxymethylation with formaldehyde. Me2P(O)H+CH2O→Me2P(O)CH2OH Many aldehydes effect a similar reaction.

References

https://en.wikipedia.org/wiki/Dimethylphosphine_oxide
http://www.sigmaaldrich.com/catalog/product/aldrich/287881?lang=en&region=US
Ganesan, Paramasivam, and S. Lakshmipathi. "Impact of heterogeneous passivation of trimethylphosphine oxide and di-methylphosphine oxide surface ligands on the electronic structure of Cd n Se n, (n =6, 15) quantum dots: A DFT study." Physica E: Low-dimensional Systems and Nanostructures 83(2016):284-296.

DIMETHYLPHOSPHINE OXIDE Preparation Products And Raw materials

Raw materials

Phosphinous amide, N,N,P,P-tetramethyl- dimethyl methylthiophosphine Phosphinous amide, N,N-diethyl-P,P-dimethyl- Phosphinous amide, P,P-dimethyl-N,N-bis(1-methylethyl)- Phosphinous acid, dimethyl-, methyl ester (8CI,9CI)

DIMETHYLPHOSPHINIC ACID CHLORO(DIMETHYL)PHOSPHINE Diethyl phosphite Methylmagnesium chloride

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Preparation Products

Benzenamine, 4-(dimethylphosphinyl)-2-methoxy-

DIMETHYLPHOSPHINE OXIDE Suppliers

Global( 168)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Neugen Labs	+91-8133254502 +91-8133254502	Karnataka, India	195	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	China	2255	58	Inquiry
Shanghai Famo Biotech Co Ltd	+86-36680037 +86-18550473860	China	528	58	Inquiry
Puyang Huicheng Electronic Materials Co., Ltd.	+86-0393-+86-0393-8910800 +8615839383373	China	524	58	Inquiry
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	China	12446	58	Inquiry
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	China	5873	58	Inquiry
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	China	20293	58	Inquiry

Supplier	Advantage
Neugen Labs	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Capot Chemical Co.,Ltd.	60
Xi'an MC Biotech, Co., Ltd.	58
Shanghai Famo Biotech Co Ltd	58
Puyang Huicheng Electronic Materials Co., Ltd.	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58

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DIMETHYLPHOSPHINOUS ACID DIMETHYLPHOSPHINE OXIDE Keto-Dimethyl-Phosphonium Dimethylphosphine Oxide Dimethyl-Oxo-Phosphonium Dimethyl-Oxophosphonium Phosphine oxide, dimethyl- (6CI,8CI,9CI) Einecs 230-591-2 Phosphine oxide, diMethyl- DIMETHYLPHOSPHINEOXIDE,MIN.95% Dimethylphosphine oxide, min. 95% dimethyl(oxo)phosphanium Dimethylphosphinoxid Methylphosphinoylmethane methylphosphonoylmethane imethyl(oxo)phosphanium 7211-39-4 2711-39-4