CYCLOHEXYL ISOCYANIDE
- CAS No.
- 931-53-3
- Chemical Name:
- CYCLOHEXYL ISOCYANIDE
- Synonyms
- HANSA ISN-0519;BIO-FARMA BF001328;ISOCYANOCYCLOHEXANE;CYCLOHEXYL ISONITRILE;CYCLOHEXYL ISOCYANIDE;Cyclohexaneisonitrile;Cyclohexane, isocyano-;Cyclohexyl #niso-cyanide;Cyclohexyl isocyanide,99%;Cyclohexyl isocyanide 98%
- CBNumber:
- CB7469738
- Molecular Formula:
- C7H11N
- Molecular Weight:
- 109.17
- MOL File:
- 931-53-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 6.45°C |
|---|---|
| Boiling point | 173-176 °C |
| Density | 0.878 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 170 °F |
| storage temp. | Store at +2°C to +8°C. |
| form | Liquid |
| color | Clear colorless to slightly brown |
| BRN | 3662332 |
| Stability | Stable. Incompatible with strong acids, strong bases, strong reducing agents, strong oxidizing agents. Flammable. |
| CAS DataBase Reference | 931-53-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P310-P302+P352+P312-P304+P340+P311 | |||||||||
| Hazard Codes | Xn,T | |||||||||
| Risk Statements | 20/21/22-23/24/25 | |||||||||
| Safety Statements | 36/37-45-24/25 | |||||||||
| RIDADR | UN 2810 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-13-21 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29299090 | |||||||||
| NFPA 704 |
|
CYCLOHEXYL ISOCYANIDE price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 133302 | Cyclohexyl isocyanide 98% | 931-53-3 | 1G | ₹4373.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 133302 | Cyclohexyl isocyanide 98% | 931-53-3 | 5G | ₹12145.65 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C1438 | Cyclohexyl Isocyanide min. 98.0 % | 931-53-3 | 1G | ₹3600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C1438 | Cyclohexyl Isocyanide min. 98.0 % | 931-53-3 | 5G | ₹12100 | 2022-05-26 | Buy |
CYCLOHEXYL ISOCYANIDE Chemical Properties,Uses,Production
Chemical Properties
colourless liquid
Uses
Cyclohexyl Isocyanide can be used as novel arginase inhibitors to treat diseases.
Preparation
CAUTION: Use a well-ventilated hood and take all precautions before using phosgene.
To a flask equipped as in Preparation 3-1 is added 1.27 kg (10.0 moles) of N-cyclohexylformamide, 3.20 liters of triethylamine, and 4.50 liters of methylene chloride. The solution is stirred while phosgene is rapidly added (300-400 gm/hr) to cause vigorous refluxing. Refluxing ceases after 1.04 kg (10.2 moles) of phosgene have been added and the addition is stopped. The reaction mixture is cooled to 22-25°C, 400 gm (23.5 moles) of ammonia gas added over a period of 1-2 hr, the mixture filtered then concentrated under reduced pressure, and the residue distilled to afford 955 gm (88%), b.p. 67-72°C (14 mm Hg).
General Description
Cyclohexyl isocyanide reacts with dimethyl acetylenedicarboxylate to give a mixture of cyclopenta[b]pyridine derivatives, azaspirononatriene derivative and the azabicyclononatriene. It reacts with dialkyl acetylenedicarboxylates to form 1:1 intermediate which on facile addition to 1-benzylisatin and tryptantrin yields highly functionalized novel unsaturated γ-spiroiminolactones.
References
[1] Khalili, Gholamhossein. “ChemInform Abstract: A Diastereoselective Synthesis of (Z)-3-[(Aryl)(hydroxyimino)methyl] -2-cyclohexyl-1-(cyclohexylamino)imidazo[5,1-a]isoquinolinium Chlorides from Isoquinoline, Chlorooximes, and Cyclohexyl Isocyanide.” ChemInform 47 25 (2016).
[2] M. Anary‐Abbasinejad, M. Heidari, N. Shams. “One-pot synthesis of highly functionalised 1H-pyrazoles from arylcarbohydrazides, cyclohexyl isocyanide, and acetylene diesters.” Arkivoc 2012 1 (2012).
[3] Anary‐Abbasinejad, M. M. Jaafari and Mahdiyeh Talebizadeh. “One-pot Four-component Reaction between Arylamines, Arylglyoxals, Cyclohexyl Isocyanide, and Acetylene Diesters: An Efficient Synthesis of 2H-iminopyran Derivatives.” 2019. 0.
[4] Alireza Hassanabadi. “ChemInform Abstract: Use of Cyclohexyl Isocyanide in the Esterification of N-Benzoyl α-Amino Acid Derivatives.” ChemInform 43 3 (2011).
[5] A. Hassanabadi. “The use of cyclohexyl isocyanide in the esterification of N -benzoyl α-amino acids derivatives.” Journal of Chemical Research-s 18 1 (2011): 468–470.
CYCLOHEXYL ISOCYANIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3887 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20235 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | China | 29730 | 60 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49732 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29808 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | China | 3922 | 58 | Inquiry |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | China | 8831 | 58 | Inquiry |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 12186 | 58 | Inquiry |
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