ACEA
- CAS No.
- 220556-69-4
- Chemical Name:
- ACEA
- Synonyms
- ACEA;2'-CHLORO-AEA;ACEA (ethanol solution);Terfenadine Impurity 23;ARACHIDONYL-2-CHLOROETHYLAMIDE;ARACHIDONYL-2'-CHLOROETHYLAMIDE;ARACHIDONOYL 2'-CHLOROETHYLAMIDE;Eicosapentaenoic Acid Impurity 51;ARACHIDONYL-2'-CHLOROETHYLAMIDE HYDRATE;N-(2-CHLOROETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE
- CBNumber:
- CB7484072
- Molecular Formula:
- C22H36ClNO
- Molecular Weight:
- 365.98
- MOL File:
- 220556-69-4.mol
- Modify Date:
- 2023/6/30 15:45:59
ACEA Chemical Properties,Uses,Production
Description
Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide (AEA; ), in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.
Uses
A synthetic agonist of the cannabinoid receptor 1 (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R).
Biological Activity
Potent and highly selective CB 1 receptor agonist (K i = 1.4 nM). Displays > 1400-fold selectivity over CB 2 receptors. Active in vivo . Also available as part of the Cannabinoid CB 1 Receptor Tocriset™ .
Enzyme inhibitor
This synthetic CB1 receptor agonist and anandamide (N- arachidonylethanolamide) analogue (FW = 365.99 g/mol; CAS 220556-69-4; Symbol: ACEA) is a selective agonist of cannabinoid receptor-1 (Ki = 1.4 nM) but has low affinity to the cannabinoid receptor 2 (Ki = 3.1 μM). ACEA inhibits forskolin-induced cAMP accumulation in Chinese hamster ovary cells expressing the human CB1 receptor. It also increases the binding of [ 35 S]GTPgS to cerebellar membranes and inhibits electrically evoked contractions of the mouse vas deferens. ACEA produces hypothermia in mice, an effect that is inhibited by co-administration of the CB1 receptor antagonist SR141716A.
ACEA Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | China | 11927 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24017 | 58 | Inquiry |
| Shanghai Xingui Biotechnology Co., Ltd. | 17501653715 | China | 10033 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9708 | 58 | Inquiry |
| Absin Bioscience Inc. | 021-38015121 15000105423 | China | 24734 | 58 | Inquiry |
| Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd | 18162595016 | China | 9887 | 58 | Inquiry |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | China | 39997 | 58 | Inquiry |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | China | 16168 | 55 | Inquiry |
| TargetMol Chemicals Inc. | 15002134094 | China | 28118 | 58 | Inquiry |