METHACHOLINE BROMIDE
- CAS No.
- 333-31-3
- Chemical Name:
- METHACHOLINE BROMIDE
- Synonyms
- Methacholine;Acetyl-βMECHOLYL BROMIDE;METHACHOLINE BROMIDE;METHYLCHOLINE BROMIDE;MethacholineBromide>(2-HYDROXYPROPYL)TRIMET;ACETYL-β-METHYLCHOLINEBROMID;ACETYL-B-METHYLCHOLINE BROMIDE;Acetyl-β-methylcholine bromide
- CBNumber:
- CB7489800
- Molecular Formula:
- C8H18BrNO2
- Molecular Weight:
- 240.14
- MOL File:
- 333-31-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:18
| Melting point | 147-149 °C(lit.) |
|---|---|
| Density | 1.3952 (rough estimate) |
| refractive index | 1.6120 (estimate) |
| storage temp. | -20°C |
| form | Crystalline Powder |
| color | White to off-white |
| Water Solubility | almost transparency |
| Sensitive | Hygroscopic |
| BRN | 6098010 |
| EPA Substance Registry System | 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, bromide (333-31-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29239000 | |||||||||
| NFPA 704 |
|
METHACHOLINE BROMIDE price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A2126 | Acetyl-β-methylcholine bromide ≥99% | 333-31-3 | 100G | ₹33060 | 2022-06-14 | Buy |
| TCI Chemicals (India) | M0072 | Methacholine Bromide | 333-31-3 | 25G | ₹4600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M0072 | Methacholine Bromide | 333-31-3 | 100G | ₹17000 | 2022-05-26 | Buy |
METHACHOLINE BROMIDE Chemical Properties,Uses,Production
Chemical Properties
WHITE CRYSTALLINE POWDER
Uses
Acetyl-β-methylcholine bromide (methylcholine bromide, methacholine bromide, Mch), a muscarinic acetylcholine receptor agonist, may be used in studies that involve the indentification, characterization and mechanism of action of muscarinic acetylcholine receptors. Mch may be used as a reference material in procedures used to detect or quantify its presence.
General Description
Methacholine can exist as (S) and (R) enantiomers.Although the chemical is used as the racemic mixture, itsmuscarinic activity resides principally in the (S)-isomer.The (S)/(R) ratio of muscarinic potency for these enantiomersis 240:1.
Mechanism of action
A minor structural change is the presence of a methyl group at the β-carbon atom of choline, which results in two main changes in the pharmacological profile of the molecule. Unlike acetylcholine, methacholine is hydrolyzed only by acetylcholinesterase, and the rate of hydrolysis is significantly less than with acetylcholine. Thus, the action of methacholine is significantly longer lasting than acetylcholine. Moreover, the presence of a methyl group at the β-carbon of choline provides the compound with a greater selectivity of action. Methacholine directly acts on muscarinic receptors of smooth muscle, glands,and the heart, and it has a very weak effect on nicotinic receptors of the autonomic ganglions of skeletal muscle.
METHACHOLINE BROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
METHACHOLINE BROMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | China | 18444 | 58 | Inquiry |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | China | 35451 | 58 | Inquiry |