Clidinium bromide | 3485-62-9

Clidinium bromide Properties

Melting point	240-241°C
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
form	Solid
color	White to Off-White
CAS DataBase Reference	3485-62-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

Xn

Risk Statements

22

Safety Statements

36

RIDADR

3249

WGK Germany

3

RTECS

VD6125000

HazardClass

6.1(b)

PackingGroup

III

HS Code

2933399090

NFPA 704

	0
2		0

Clidinium bromide price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C0414	Clidinium bromide analytical standard	3485-62-9	1G	₹9341.98	2022-06-14	Buy

Product number	Packaging	Price	Buy
C0414	1G	₹9341.98	Buy

Clidinium bromide Chemical Properties,Uses,Production

Description

Clidinium is a gastrointestinal muscarinic receptor antagonist (K_i = 3 nM against [³H]quinuclidinyl benzilate binding in rat colonic enterocytes). Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice. This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.

Chemical Properties

White Crystalline Solid

Uses

Clidinium inhibits muscarinic action of acetylcholine on postganglionic parasympathetic effector regions. It is used for treating stomach ulcers.

Definition

ChEBI: The bromide salt of clinidium. It is used for the symptomatic treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.

General Description

Clidinium bromide, 3-hydroxy-1-methylquinuclidinium bromide benzilate (Quarzan),is a white or nearly white, almost odorless, crystalline powderthat is optically inactive. It is soluble in water and alcohol butonly very slightly soluble in ether and benzene.

Clinical Use

This anticholinergic agent is marketed alone and in combinationwith the minor tranquilizer chlordiazepoxide (Librium)in a product known as Librax. The rationale of the combinationfor the treatment of GI complaints is the use of an anxiety-reducing agent together with an anticholinergic agent,based on the recognized contribution of anxiety to the developmentof the diseased condition. It is suggested for pepticulcer, hyperchlorhydria, ulcerative or spastic colon, anxietystates with GI manifestations, nervous stomach, irritable orspastic colon, and others. Clidinium bromide is contraindicatedin glaucoma and other conditions that may be aggravatedby the parasympatholytic action, such as prostatic hypertrophyin elderly men, which could lead to urinary retention.

Synthesis

Clidinium, 3-benzyloyloxy-1-methylcynuclidinium bromide (14.1.19), is synthesized by reacting 3-hydroxycynuclidine (14.1.17) with the of benzilic acid chloride producing the ester (14.1.18), which if further alkylated at the nitrogen atom by methylbromide, giving clidinium (14.1.19) [16].

Synthesis_3485-62-9

Clidinium bromide Preparation Products And Raw materials

Raw materials

Methyl bromide 2-CHLORO-2,2-DIPHENYLACETYL CHLORIDE Sodium

Preparation Products

Clidinium bromide Suppliers

Global( 123)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
RESONANCE LABS	+91-8027630180 +91-8027630180	Karnataka, India	32	58	Inquiry
R L Fine Chem Pvt. Ltd	+91-8042488999 +91-8042488999	Karnataka, India	74	58	Inquiry
OCEAN TRADING CORPORATION	+91(22) 24921669	New Delhi, India	6211	58	Inquiry
MSN LABORATORIES PRIVATE LTD	+91 40 30438600	New Delhi, India	230	58	Inquiry
RAKS PHARMA PVT LTD	+91 891 3081555	New Delhi, India	65	58	Inquiry
RESONANCE LABORATORIES PVT LTD	+91 8027630180	New Delhi, India	15	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry

Supplier	Advantage
RESONANCE LABS	58
R L Fine Chem Pvt. Ltd	58
OCEAN TRADING CORPORATION	58
MSN LABORATORIES PRIVATE LTD	58
RAKS PHARMA PVT LTD	58
RESONANCE LABORATORIES PVT LTD	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
SynZeal Research Pvt Ltd	58

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RO-2-3773 quinuclidinolmethylbromide,benzilate 3-[(Hydroxyphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2,2,2]octane Bromide, Ro-2-3773, Quarzan (1-Methyl-1-azoniabicyclo[2.2.2]octan-8-yl) 2-hydroxy-2,2-diphenylacetate bromide 1-Azoniabicyclo[2.2.2]octane, 3-[(hydroxydiphenylacetyl)oxy]-1-methyl-, bromide 3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane bromide Ro-3773 3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane Clidinium Brimide Clidinium Bromide (500 mg) Clidinium Bromide (2 g) 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-Methyl-1-azabicyclo[2.2.2]octan-1-iuM broMide 1-methyl-3-benzil-oxyloxy-quinuclidiniumbromide 3-((hydroxydiphenylacetyl)oxy)-1-methyl-1-azoniabicyclo(2.2.2)octanbromi CLIDINIUM BROMIDE 3-[(HYDROXYPHENYLACETYL)OXY]-1-METHYL-1-AZONIABICYCLO[2,2,2]OCTANE BROMIDE 3-HYDROXY-1-METHYLQUINUCLIDINIUM BROMIDE BENZILATE 3-(2,2-diphenyl-2-hydroxyethanoyloxy)-quinuclidiniumbromide 3-(benziloyloxy)-1-methylquinuclidiniumbromide benzilicacid,esterwith3-hydroxy-1-methylquinuclidinium quarzanbromide quinuclidinium,3-hydroxy-1-methyl-,bromide,benzilate Clidinium iodide D3 2-hydroxy-2,2-diphenylacetic acid (1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl) ester bromide 3-(2-Hydroxy-2,2-diphenylacetoxy)-1-methylquinuclidin-1-ium bromide Clidinium BromideQ: What is Clidinium Bromide Q: What is the CAS Number of Clidinium Bromide Q: What is the storage condition of Clidinium Bromide Q: What are the applications of Clidinium Bromide Clidinium-D5 bromideQ: What is Clidinium-D5 bromide Q: What is the CAS Number of Clidinium-D5 bromide Clidinium Bromide (1135000) AV 54315 AV54315 AV-54315 QUARZAN Clidinium 3485-62-9 C22H26NO3Br C22H26BO3Rn C22H26BrNO3 Alphabetic Analytical Chromatography Product Catalog Analytical Standards CI - CL QUARZAN Intermediates & Fine Chemicals Pharmaceuticals