FORTUNELLIN
- CAS No.
- 20633-93-6
- Chemical Name:
- FORTUNELLIN
- Synonyms
- FORTUNELLIN;ACACETIN-7-NEOHESPERIDOSIDE;ACACETIN-7-O-NEOHESPERIDOSIDE;4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-
- CBNumber:
- CB7713662
- Molecular Formula:
- C28H32O14
- Molecular Weight:
- 592.55
- MOL File:
- 20633-93-6.mol
- Modify Date:
- 2024/7/2 8:55:17
FORTUNELLIN Chemical Properties,Uses,Production
Description
Fortunellin is a potential anti-inflammation agent in inflammatory diseases, it targets miR-374a, which is a negative regulator of phosphatase and tensin homolog (PTEN). Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation.
Chemical Properties
Off-white to light yellow Solid
Uses
Fortunellin is a flavonoid that can be isolated from kumquat (Fortunella margarita) fruit. Studies have shown that Fortunellin inhibits LPS-induced inflammation and ROS production in H9C2 cells, and also prevents fructose-induced inflammation and oxidative stress by enhancing the AMPK/Nrf2 pathway. In addition, Fortunellin has a dual role in the prevention and treatment of coronaviral disease, with antiviral activity against SARS-CoV-2 and anti-inflammatory immunomodulatory capacity in the host.
Biological Functions
Fortunellin (acacetin 7-O-neohesperidoside) is a citrus flavonoid isolated from kumquat fruit. Kumquat extract has attracted much attention recently for its beneficial effects on human health, which include antitumor, antioxidant and anti-inflammatory characteristics . The beneficial effects of flavonoids on IBD have been confirmed in many studies. However, although fortunellin is the main flavonoid in kumquat, there is a lack of information on its alleviation of IBD.
Mechanism of action
Fortunellin is a citrus flavonoid that is a potential anti-inflammation agent in inflammatory diseases. Fortunellin ameliorated colitis symptoms, including excessive inflammation and oxidative stress. Fortunellin decreased epithelial cell apoptosis through inhibiting PTEN expression in colitis. Fortunellin-induced downregulation of PTEN could be counteracted by miR-374a depletion. Moreover, knockdown of miR-374a in vivo partly inhibited the effects of fortunellin on rat colitis.
FORTUNELLIN Preparation Products And Raw materials
FORTUNELLIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9626 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | China | 4692 | 58 | Inquiry |
| ABCR GmbH & CO. KG | 49 721 95061 0 | Germany | 6846 | 75 | Inquiry |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | China | 7059 | 55 | Inquiry |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | China | 8012 | 62 | Inquiry |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 13720134139 | China | 5348 | 58 | Inquiry |
| Olix (Shanghai) Pharmaceutical Technology Co., Ltd | 17316404525 | China | 9627 | 58 | Inquiry |
| SHANGHAI ZZBIO CO., LTD. | 19921389125 19921389125 | China | 12065 | 58 | Inquiry |