Acacetin
- CAS No.
- 480-44-4
- Chemical Name:
- Acacetin
- Synonyms
- Abietic;acacetine;5,7-dihydroxy-4’-methoxy-flavon;ACACETIN;LY 064233;NSC 76061;LINARIGENIN;Linarisenin;Acacetin-RM;ACACETIN hplc
- CBNumber:
- CB9316535
- Molecular Formula:
- C16H12O5
- Molecular Weight:
- 284.26
- MOL File:
- 480-44-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 260-265 °C(lit.) |
|---|---|
| Boiling point | 346.76°C (rough estimate) |
| Density | 1.2160 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Very Slightly, Heated) |
| form | Solid |
| pka | 6.51±0.40(Predicted) |
| color | Light Yellow to Green-Yellow to Dark Yellow |
| λmax | 335nm(EtOH)(lit.) |
| Merck | 14,13 |
| BRN | 277879 |
| InChIKey | DANYIYRPLHHOCZ-UHFFFAOYSA-N |
| LogP | 2.443 (est) |
| CAS DataBase Reference | 480-44-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P337+P313-P261 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DJ3002000 | |||||||||
| F | 3-8-10 | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
Acacetin price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 00017 | Acacetin ≥97.0% (HPLC) | 480-44-4 | 25MG | ₹10944.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 49975 | Acacetin analytical standard | 480-44-4 | 10MG | ₹21011.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 00017 | Acacetin ≥97.0% (HPLC) | 480-44-4 | 100MG | ₹55943.6 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A3013 | Acacetin min. 98.0 % | 480-44-4 | 25MG | ₹8300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A3013 | Acacetin min. 98.0 % | 480-44-4 | 100MG | ₹9800 | 2022-05-26 | Buy |
Acacetin Chemical Properties,Uses,Production
Description
Acacetin is an O-methylated flavone found in various plants. It is reported to demonstrate spasmolytic, antinociceptive, anti-inflammatory, and antioxidant activity in various research models.
Chemical Properties
Yellow Solid
Uses
VEGF expression inhibitor and tumor angiogenesis. A flavonoid with antiaggregatory activity in human blood.
Definition
ChEBI: A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.
General Description
Acacetin belongs to the category of naturally occurring plant pigments called flavonoids found in vascular plants. It was first reported to be extracted from the leaves of Robinia pseuducacia. It has been used as an active component of traditional Chinese medicine Xuelianhua.
Enzyme inhibitor
This naturally occurring flavone (FW = 286.27 g/mol; CAS 480-44-4), also known as 5,7-dihydroxy-4’-methoxyflavone and 7-O-methylapigenin, and systematically named as 5,7-dihydroxy-2-(4-methoxyphenyl)-chromen-4- one, from the black locust Robinia pseudoacacia is the aglycon of linarin and acaciin and is biosynthesized by apigenin 4'-O-methyltransferase from S-adenosyl-methionine and 5,7,4’-trihydroxyflavone (apigenin), yielding Sadenosylhomocysteine and acacetin. The chemical synthesis of acacetin was accomplished by Robert Robinson, who was awarded the 1947 Nobel Prize in Chemistry for his work on alkaloids and organic synthesis. Target(s): glutathione S-transferase; xanthine oxidase, Ki = 0.11 μM; CYP1A; CYP1B1; glutathione-disulfide reductase; DNA topoisomerase I; [myosin light-chain] kinase; and protein-tyrosine kinase, or non-specific protein-tyrosine kinase.
Acacetin Preparation Products And Raw materials
Raw materials
1of3
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SynthoCascade Research Laboratories | +91-9440962500 +91-9440962500 | Telangana, India | 284 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| Merit International | 91-22-40150081 | Maharashtra, India | 226 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Evans Fine Chem | 08048602255 | Hyderabad, India | 289 | 58 | Inquiry |
| Biosyn Research Chemicals | +91 9346022300/+91 9399339999 | Telangana, India | 1340 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3887 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | China | 3003 | 58 | Inquiry |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | China | 7245 | 58 | Inquiry |