Mofezolac
- CAS No.
- 78967-07-4
- Chemical Name:
- Mofezolac
- Synonyms
- N-22;Disopain;Mofezolac;3,4-Bis(4-methoxyphenyl)isoxazole-5-acetic acid;3,4-Bis(4-methoxyphenyl)-5-isoxazoleacetic acid;5-Isoxazoleacetic acid, 3,4-bis(4-methoxyphenyl)-;2-(3,4-bis(4-Methoxyphenyl)isoxazol-5-yl)acetic acid;α-[3,4-Bis(4-methoxyphenyl)-5-isoxazolyl]acetic acid;Mofezolac,inhibit,platelet,COX,Inhibitor,aggregation,NSAID,Cyclooxygenase,pain,anti-inflammatory,COX-1,analgesic
- CBNumber:
- CB7875698
- Molecular Formula:
- C19H17NO5
- Molecular Weight:
- 339.34
- MOL File:
- 78967-07-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:17
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H319 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 1528, 1740, 920, 887 orally; 275, 321, 378, 342 i.p.; 612, 545, 572, 510 s.c. (Satoh) | |||||||||
| NFPA 704 |
|
Mofezolac Chemical Properties,Uses,Production
Description
Mofezolac is a new non-steroidal analgesic antiinflammatory agent introduced in Japan for the treatment of post-operative and post-traumatic pain, acute upper respiratory tract pain, osteoarthritis, and lumbago. In in vfim studies, mofezolac inhibits prostaglandin biosynthesis and platelet aggregation, reportedly through the inhibition of cyclooxygenase. In animal studies, mofezolac showed more potent suppression in various writhing models than agents such as ibuprofen, mefenamic acid and aspirin. Mofezolac also has a potent inhibitory activity on the algesic responses induced by the mechanical stimulus of the inflamed tissue. The ulcerogenic effect of mofezolac on the gastric mucosa is far weaker than that of indomethacin and other agents.
Originator
Pasteur Merieux (France)
brand name
Disopain
Mofezolac Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |