(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile

CAS No.: 38321-02-7

Chemical Name:: (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile

Synonyms: d-Verapamil;Dexverapami;Dexverapamil;Dexverapamil Hydrochloride;[R,(+)]-2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(N-methyl-3,4-dimethoxyphenethylamino)valeronitrile;(R)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile;(aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile;(αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile;Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (R)-;Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, (αR)-

CBNumber:: CB7941337

Molecular Formula:: C27H38N2O4

Molecular Weight:: 454.61

MOL File:: 38321-02-7.mol

Modify Date:: 2023/7/8 8:28:38

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(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Properties

Melting point	129-131°C
Boiling point	586.1±50.0 °C(Predicted)
Density	1.058±0.06 g/cm3(Predicted)
pka	8.97±0.50(Predicted)

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells

Definition

ChEBI: A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby p tentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil.

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Suppliers

Global( 12)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	China	18488	58	Inquiry
QUALITY CONTROL SOLUTIONS LTD.	13670046396	China	18865	58	Inquiry
TargetMol Chemicals Inc.	15002134094	China	28118	58	Inquiry
3B Scientific Corporation	847.281.9822	United States	6744	47	Inquiry
2A PharmaChem USA	(630) 737-0988	United States	6148	39	Inquiry
Lanospharma Laboratories Co.,Ltd	13440048448	China	6343	56	Inquiry
Leancare Ltd.	+33 962096793	United Kingdom	6460	42	Inquiry
Toronto Research Chemicals	+1 (416) 665-9696	Canada	6088	71	Inquiry

Supplier	Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Changzhou Bojia Biomedical Technology Co., Ltd.	58
QUALITY CONTROL SOLUTIONS LTD.	58
TargetMol Chemicals Inc.	58
3B Scientific Corporation	47
2A PharmaChem USA	39
Lanospharma Laboratories Co.,Ltd	56
Leancare Ltd.	42
Toronto Research Chemicals	71

38321-02-7((+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile)Related Search:

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile 2-(4-Methoxyphenyl)-2-methylpropanenitrile Devapamil (+/-)-Verapamil hydrochloride METHOXY-(-)-VERAPAMIL HYDROCHLORIDE

R(+)-VERAPAMIL HYDROCHLORIDE 3-Methyl-2-(3,4-dimethoxyphenyl)butyronitrile 4-HYDROXY-3-METHOXYPHENYLACETONITRILE Verapamil (3,4-Dimethoxyphenyl)acetonitrile

Benzeneacetonitrile Valeronitrile P-O-DESMETHYL VERAPAMIL 1-(3,4-DIMETHOXYPHENYL)-VALERONITRILE NORVERAPAMIL

Emopamil 2-(3-METHOXYPHENYL)-2-METHYLPROPANENITRILE 2-(4-HYDROXYPHENYL)-2-METHYLPROPANENITRILE

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Dexverapamil (aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile Dexverapami Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (aR)- (9CI) Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (R)- d-Verapamil (aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile Hydrochloride Dexverapamil Hydrochloride (R)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile (αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile [R,(+)]-2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(N-methyl-3,4-dimethoxyphenethylamino)valeronitrile Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, (αR)- 38321-02-7 C27H39ClN2O4 Intermediates & Fine Chemicals Pharmaceuticals