Tetraethylene glycol p-toluenesulfonate
- CAS No.
- 77544-60-6
- Chemical Name:
- Tetraethylene glycol p-toluenesulfonate
- Synonyms
- PEG5-Tos;Tos-PEG4;Tos-PEG4-OH;OH-PEG4-Tos;PEG5-Tosylate;Hydroxy-PEG5-Tos;HO-(CH2CH2O)4-Tos;Tetraethylene glycol tosylate;Tetraethylene glycol monotosylate;Monotosylated tetraethylene glycol
- CBNumber:
- CB81231414
- Molecular Formula:
- C15H24O7S
- Molecular Weight:
- 348.41
- MOL File:
- 77544-60-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/25 20:41:16
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05,GHS06 |
---|---|
Signal word | Danger |
Hazard statements | H301-H314 |
Precautionary statements | P270-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
Hazard Codes | T,Xi |
Risk Statements | 25-34-36 |
Safety Statements | 26-36/37/39-45 |
RIDADR | UN 2927 8(6.1) / PGII |
WGK Germany | 3 |
Tetraethylene glycol p-toluenesulfonate Chemical Properties,Uses,Production
Uses
Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.
Preparation
Synthesis of tetraethylene glycol tosylate. To a solution of tetraethylene glycol (2.22 g, 11.4 mmol, 3.8 equiv) in THF at 0 °C was added 2.5 M NaOH (2 mL, 5.0 mmol, 1.7 equiv) and stirred for 30 min. Tosyl chloride (565.3 mg, 3.0 mmol, 1 equiv) was added in small portions and the mixture stirred for 5 h. The solvent was removed under reduced pressure, and the residue was taken up in CH2Cl2 (15 mL) and washed with water (3 × 10 mL). The aqueous wash was further extracted with CH2Cl2 (3 × 10 mL) and the combined organic fractions were washed with brine and dried over anhydrous Na2SO4. The dried solution was filtered and the filtrate was concentrated under reduced pressure to give 900.8 mg of a pale yellow oil (87%). The product was sufficiently pure to be used without further purification.
Tetraethylene glycol p-toluenesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
chevron_rightSupplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | China | 10297 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 | China | 19915 | 58 | Inquiry |
Labnetwork lnc. | +86-27-50766799 +8618062016861 | China | 19994 | 58 | Inquiry |
Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | China | 19185 | 58 | Inquiry |
Supplier | Advantage |
---|---|
CHEMSWORTH | 30 |
A.J Chemicals | 58 |
ATK CHEMICAL COMPANY LIMITED | 60 |
Chongqing Chemdad Co., Ltd | 58 |
Fuxin Pharmaceutical | 58 |
TargetMol Chemicals Inc. | 58 |
Career Henan Chemica Co | 58 |
Nextpeptide Inc | 58 |
Labnetwork lnc. | 58 |
Aromsyn Co., Ltd. | 58 |
77544-60-6(Tetraethylene glycol p-toluenesulfonate)Related Search:
1of4
chevron_right