2-Bromo-3-methylthiophene
- CAS No.
- 14282-76-9
- Chemical Name:
- 2-Bromo-3-methylthiophene
- Synonyms
- 2B3MT;178.04;TH1-Br;2-Bromo-3-methylthio;2-bromo-3-methyltiophene;3-Methyl-2-bromothiophene;2-BROMO-3-METHYLTHIOPHENE;Thiophene,2-bromo-3-methyl-;2-Bromo-3-methylthiophene>2-Bromo-3-methylthiophene 97%
- CBNumber:
- CB8147031
- Molecular Formula:
- C5H5BrS
- Molecular Weight:
- 177.06
- MOL File:
- 14282-76-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/1/23 14:06:52
| Melting point | <25 °C |
|---|---|
| Boiling point | 173-176 °C (lit.) |
| Density | 1.572 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 155 °F |
| storage temp. | 2-8°C |
| solubility | soluble in Chloroform, Ethyl Acetate |
| Water Solubility | Insoluble in water |
| form | liquid |
| Specific Gravity | 1.580 |
| color | Pale yellow |
| BRN | 105719 |
| CAS DataBase Reference | 14282-76-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Thiophene, 2-bromo-3-methyl-(14282-76-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | T,Xi,Xn | |||||||||
| Risk Statements | 25-41-43-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2810 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | IRRITANT-HARMFUL, KEEP COLD | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
2-Bromo-3-methylthiophene price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 337021 | 2-Bromo-3-methylthiophene 95% | 14282-76-9 | 1G | ₹1656.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 337021 | 2-Bromo-3-methylthiophene 95% | 14282-76-9 | 1G | ₹1656.23 | 2022-06-14 | Buy |
| Sigma-Aldrich | 337021 | 2-Bromo-3-methylthiophene 95% | 14282-76-9 | 5G | ₹4979.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 337021 | 2-Bromo-3-methylthiophene 95% | 14282-76-9 | 5G | ₹4979.5 | 2022-06-14 | Buy |
| TCI Chemicals (India) | B1025 | 2-Bromo-3-methylthiophene min. 98.0 % | 14282-76-9 | 5G | ₹3100 | 2022-05-26 | Buy |
2-Bromo-3-methylthiophene Chemical Properties,Uses,Production
Chemical Properties
clear colorless to light yellow liquid
Uses
2-Bromo-3-methylthiophene was used in the preparation of poly(3,3′′′-dimethyl-(2,2′:5′,2′:5′,2′′′)tetrathiophene)). It was also used in the preparation of 2-bromo-3-(bromomethyl)thiophene, lachrymatory compound.
Application
2-Bromo-3-methylthiophene is used as a pharmaceutical intermediate. It is used to prepare pyrazolo[3,4-d]pyrimidine derivatives as inhibitors of human enterovirus, coxsackievirus, echovirus, influenza virus, herpes simplex virus and rhinovirus. It is also used in the synthesis of oral α7 nicotinic receptor agonists.
Preparation
2-Bromo-3-methylthiophene synthesis: To a solution of glacial AcOH (100 mL), acetic anhydride (4.0 g, 0.039 mol), and 3-methylthiophene (9.82 g, 0.100 mol) as a stirred mixture was added NBS (19.6 g, 0.11 mol) in one portion with a slight exotherm to 44 oC. After 20 min the reaction mixture was poured onto ice, neutralized with sodium bisulfite and extracted with ether. The ether layer was washed with water and concentrated to give 11.3 g (64%) of 2-bromo-3-methylthiophene as a tan colored liquid in 88% purity by GC area % analysis: 1H NMR (CDCl3) d 7.1 (d, 1H, J=5.7 Hz), 6.7 (d, 1H, J=5.9 Hz), 2.2 (s, 3H).
General Description
2-Bromo-3-methylthiophene is formed (approx. 90%) by bromination of 3-methyl thiophene with N-bromosuccinimide in the absence of benzoyl peroxide.
2-Bromo-3-methylthiophene Preparation Products And Raw materials
Raw materials
Preparation Products
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