Abacavir-d4
![Abacavir-d4 Structure](CAS/GIF/1260619-56-4.gif)
- CAS No.
- 1260619-56-4
- Chemical Name:
- Abacavir-d4
- Synonyms
- ABC-d4;Ziagen-d4;1592U89-d4;Abacavir-d4;Abacavir D4 HCl;Abacavir-d4;(1S,4R)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene-1-Methanol;(1S,4R)-4-[2-Amino-6-[(cyclopropyl-d4)amino]-9H-purin-9-yl]-2-cycpentene-1-methanol;(1S-cis)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-Methanol;((1S,4R)-4-(2-amino-6-((cyclopropyl-2,2,3,3-d4)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
- CBNumber:
- CB81565155
- Molecular Formula:
- C14H18N6O
- Molecular Weight:
- 286.33232
- MOL File:
- 1260619-56-4.mol
- Modify Date:
- 2023/6/8 9:03:01
Abacavir-d4 Chemical Properties,Uses,Production
Description
Abacavir-d4 is intended for use as an internal standard for the quantification of abacavir by GC- or LC-MS. Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 μM for the wild-type enzyme). It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3''-azido-3''-deoxythymidine (zidovudine; ) or 2'',3''-dideoxyinosine (didanosine; ), in HeLa cells stably expressing CD4 (IC50s = 5.8-21 μM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC50 value of 0.26 μM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC50 = 7 μM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC50s = 32 and 0.4 μM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.
Chemical Properties
White Solid
Uses
A labelled nucleoside reverse transcriptase inhibitor (NRTI)
Abacavir-d4 Preparation Products And Raw materials
Raw materials
Preparation Products
Abacavir-d4 Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | China | 9592 | 60 | Inquiry |
Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | China | 8739 | 58 | Inquiry |
Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | China | 12582 | 58 | Inquiry |
Medical Isotopes | 1-(603) 635-1722 | United States | 6185 | 68 | Inquiry |
TLC PharmaChem Inc. | (905) 268-0252 | Canada | 922 | 60 | Inquiry |
Toronto Research Chemicals | +1 (416) 665-9696 | Canada | 6088 | 71 | Inquiry |
1260619-56-4(Abacavir-d4)Related Search:
1of4
chevron_right