Trehalose
- CAS No.
- 99-20-7
- Chemical Name:
- Trehalose
- Synonyms
- α,α-trehalose;D-TREHALOSE;MYCOSE;alpha,alpha-Trehalose;alpha-d-glucopyranoside;Trehalose RS;Trehalose solution;TREHALOSE;Crehalose;Trehelose
- CBNumber:
- CB8210805
- Molecular Formula:
- C12H22O11
- Molecular Weight:
- 342.3
- MOL File:
- 99-20-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/25 20:17:06
| Melting point | 203 °C |
|---|---|
| Boiling point | 397.76°C (rough estimate) |
| Density | 1.5800 |
| vapor pressure | 0.001Pa at 25℃ |
| refractive index | 197 ° (C=7, H2O) |
| RTECS | LZ5776770 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in water; very slightly soluble in ethanol (95%); practically insoluble in ether. |
| pka | 12.53±0.70(Predicted) |
| form | Powder |
| color | White to Off-white |
| Water Solubility | Soluble in water. |
| Sensitive | Hygroscopic |
| Merck | 14,9580 |
| LogP | 0 at 25℃ |
| CAS DataBase Reference | 99-20-7(CAS DataBase Reference) |
| EPA Substance Registry System | Trehalose (99-20-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 38 |
| Safety Statements | 37/39-26 |
| TSCA | Yes |
| HS Code | 29400090 |
Trehalose price More Price(2)
Trehalose Chemical Properties,Uses,Production
Chemical Properties
Trehalose occurs as virtually odorless, white or almost white crystals with a sweet taste (approximately 45% of the sweetness of sucrose).
Uses
trehalose is a humectant and moisturizer, it helps bind water in the skin and increase the skin’s moisture content. It is a naturally occurring plant sugar.
Production Methods
Trehalose is prepared from liquefied starch by a multistep enzymatic process. The commercial product is the dihydrate.
Definition
ChEBI: A trehalose in which both glucose residues have alpha-configuration at the anomeric carbon.
Pharmaceutical Applications
Trehalose is used for the lyoprotection of therapeutic proteins, particularly for parenteral administration. Other pharmaceutically relevant applications include use as an excipient for diagnostic assay tablets; for stabilization during the freeze–thaw and lyophilization of liposomes; and for stabilization of blood cells, cosmetics, and monoclonal antibodies. Trehalose may also be used in formulations for topical application.
Safety
Trehalose is used in cosmetics, foods, and parenteral and
nonparenteral pharmaceutical formulations. It is generally regarded
as a relatively nontoxic and nonirritant material when used as an
excipient.
In the gut, trehalose is rapidly metabolized to glucose by the
specific enzyme trehalase. A small minority of the population
exhibits a primary (hereditary) or secondary (acquired) trehalase
deficiency and thus may experience intestinal discomfort after
ingestion of excessive amounts of trehalose owing to the osmotic
activity of undigested trehalose in the gut. However, smaller
amounts of trehalose are tolerated by such individuals without
any symptoms.
Trehalose is used as a sweetener and is reported to have
substantially less cariogenic potential than sucrose.
LD50 (dog, IV): >1 g/kg
LD50 (dog, oral): >5 g/kg
LD50 (mouse, IV): >1 g/kg
LD50 (mouse, oral): >5 g/kg
LD50 (rat, IV): >1 g/kg
LD50 (rat, oral): >5 g/kg
storage
Trehalose is a relatively stable material. At 60°C for 5 hours it loses
not more than 1.5% w/w of water (the dihydrate water of crystallization is retained). Open stored powder may liquefy at high
relative humidity (≥90%).
Trehalose should be stored in a cool, dry place in a well-sealed
container.
Incompatibilities
Trehalose is incompatible with strong oxidizing agents, especially in the presence of heat.
Regulatory Status
GRAS listed. In the UK trehalose may be used in certain food applications. Included in parenteral and nonparenteral investigational formulations.
Trehalose Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| ALPHA CHEMIKA | +91-22-22061123 +91-22-66382501 | Mumbai, India | 1681 | 43 | Inquiry |
| Scientific OEM | +91-22- 2343 7546 / 2341 3094 | New Delhi, India | 1996 | 38 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Nagase India Private Limited | 08048372115Ext 872 | Mumbai, India | 2 | 58 | Inquiry |
| Mitushi Biopharma | 08046058050 | Ahmedabad, India | 47 | 58 | Inquiry |
| P C Chem | +91-8046061281 | Mumbai, India | 676 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CHEMSWORTH | 30 |
| ALPHA CHEMIKA | 43 |
| Scientific OEM | 38 |
| Maas Pharma Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Nagase India Private Limited | 58 |
| Mitushi Biopharma | 58 |
| P C Chem | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
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