ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Proteases >Cysteine ??Protease Inhibitors >EST
EST
- CAS No.
- 88321-09-9
- Chemical Name:
- EST
- Synonyms
- EST;E-64D;ep453;Estate;CS-1622;oxistatin;NSC694281;LOXISTATIN;LOXASTATIN;E64d,E-64d
- CBNumber:
- CB8228758
- Molecular Formula:
- C17H30N2O5
- Molecular Weight:
- 342.43
- MOL File:
- 88321-09-9.mol
- Modify Date:
- 2023/9/4 15:51:00
| Melting point | 126.2°C |
|---|---|
| Boiling point | 477.88°C (rough estimate) |
| Density | 1.0657 (rough estimate) |
| refractive index | 1.5800 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO, DMF or ethanol |
| pka | 13.32±0.40(Predicted) |
| form | White solid |
| color | Fine needles from EtOH |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| RIDADR | 3077 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | RR0404300 | |||||||||
| HS Code | 29242990 | |||||||||
| Toxicity | cyt-ham:lng 200 mg/L IYKEDH 17,815,86 | |||||||||
| NFPA 704 |
|
EST price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | E8640 | E-64d protease inhibitor | 88321-09-9 | 250μG | ₹15782.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E8640 | E-64d protease inhibitor | 88321-09-9 | 1MG | ₹43343.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C1370 | COT (30-397), active, GST tagged human PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 88321-09-9 | 10μG | ₹48240.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 330005 | EST - CAS 88321-09-9 - Calbiochem A cell-permeable, irreversible inhibitor of cysteine proteases. | 88321-09-9 | 1MG | ₹16670.01 | 2022-06-14 | Buy |
| TCI Chemicals (India) | E1337 | E-64d [for Biochemical Research] | 88321-09-9 | 5MG | ₹6600 | 2022-05-26 | Buy |
EST Chemical Properties,Uses,Production
Description
E-64d is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases and has diverse biological activities. It is a synthetic analog of E-64 and prodrug form of E-64c that inhibits calpain and the cysteine proteases cathepsins F, -K, -B, -H, and -L. E-64d (20-200 μM) induces cell cycle arrest at the G2/M phase in A431 human epidermoid carcinoma cells. It inhibits protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells with an IC50 value of 0.5 μM. E-46d also inhibits entry of vesicular stomatitis virus (VSV) particles pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) or SARS-CoV-2 spike glycoprotein into Vero cells, an effect that is reduced by expression of the serine protease TMPRSS2.
Definition
ChEBI: An L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of (2S,3S)-3-(ethoxycarbonyl)oxirane-2-carboxylic acid with the amino group of N-(3-methylb tyl)-L-leucinamide.
Safety Profile
Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.
EST Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 172)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | China | 888 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | China | 19915 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |
88321-09-9(EST)Related Search:
GLYCIDAMIDE
(S)-(+)-Methyl glycidyl ether
EST
(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID
2-Hydroxy-4-amino butanoic acid
NALPHA-9-Fluorenylmethoxycarbonyl-S-trityl-L-cysteine pentafluorophenyl est
2,2'-[[4-[(3,5-dinitro-2-thienyl)azo]phenyl]imino]bis-ethano diacetate (est
(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC*ACID METHYL EST
Isothiocyanic acid isobutyl est
n-[3-(acetylamino)phenyl]-n-(3-methoxy-3-oxopropyl)-beta-alanin methyl est
1,2-CYCLOHEXANEDICARBOXYLICACID,BIS(2,3-EPOXYPROPYL)EST.
1,2,3,4,4a,4b,5, 6,7,9,10,10a-dodecahydro-1,4a-dimethyl-7- (1-methylethyl)-, 1,2,3-propanetriyl est1-Phenanthrenecarboxylic acid
8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL EST
ETHYL (2S)-2,3-EPOXYPROPANOATE
2(2-HYDROXYETHOXY)ACETAMIDE
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COT (30-397), active, GST tagged human
2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,ethyl ester, (2S,3S)-
E 64d (Aloxistatin)
(2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]-butyl]amino]carbonyl]-2-oxiranec
L-TRANS-EPOXYSUCCINYL-LEU-3-METHYLBUTYLAMIDE-ETHYL ESTER
L-TRANS-EPOXYSUCCINYL(OET)-LEU-3-METHYLBUTYLAMIDE
LOXASTATIN
LOXISTATIN
(L-3TRANS-ETHOXYCARBONYLOXIRANE-2-CARBONYL)-L-LEUCINE-(3-METHYLBUTYL)AMIDE
EST
E-64D
(2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-Methylbutyl)aMino]carbonyl]butyl]aMino]carbonyl]-2-oxiranecarboxylic acid ethyl ester
(2S,3S)-trans-Epoxysuccinyl-L-leucylaMido-3-Methylbutane ethyl ester, EST
(2S,3S)-ethyl 3-(((S)-1-(isopentylaMino)-4-Methyl-1-oxopentan-2-yl)carbaMoyl)oxirane-2-carboxylate
E-64-D(LOXISTATINE)
Estate
oxistatin
E64d,E-64d
E-64(Trans-Epoxysuccinyl-L-Leucylamido-(4-Guanidino)Butane)
L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbuty
trans-epoxysuccinyl-L-leucylamido 3-methylbutane ethyl
EST, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester
(2S,3S)-trans-epoxysuccinyl-L-*leucylamido-3-meth
aloxistatin
(2S)-3β-[[[(S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]oxirane-2α-carboxylic acid ethyl ester
[2S,3S,(+)]-3β-[(S)-3-Methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl]-2α-oxiranecarboxylic acid ethyl ester
E-64d, L-trans-Epoxysuccinyl(OEt)-Leu-3-MethylbutylaMide, EP453, Aloxistatin, Loxistatin
ep453
ethylester,(2s-(2-alpha,3-beta(r*)))-mino)carbonyl)
(2S,3S)-ETHYL-TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-3-METHYLBUTANE
(2S,3S)-TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-3-METHYLBUTANE ETHYL ESTER
3-[[[(1S)-3-methyl-1[[(3S-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2S-oxiranecarboxylic acid, ethyl ester
EST - CAS 88321-09-9 - Calbiochem
CS-1622
ALOXISTATIN;E64D;E 64D;LOXISTATIN;E-64C ETHYL ESTER;EP 453;NSC 694281;NSC694281;NSC-694281
NSC 694281
NSC694281
NSC-694281
(2S,3S)-3-[[(2S)-4-Methyl-1-[(3-methylbutyl)amino]-1-oxo-2-pentanyl]carbamoyl]-2-oxiranecarboxylic Acid Ethyl Ester
Ethyl (2S,3S)-3-[[(2S)-4-Methyl-1-[(3-methylbutyl)amino]-1-oxo-2-pentanyl]carbamoyl]-2-oxiranecarboxylate
Aloxistatin (Loxistatin
E64d, NSC-694281)
Ethyl (2S,3S)-3-(((S)-1-(isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylate
Aloxistatin (E-64d) EST Loxistatin
Aloxistatin (E64d
Aloxistatin(E-64d)
E64c ethyl ester)
Aloxistatin, 98%, irreversible cell-permeable cysteine protease inhibitor
E-64d [for Biochemical Research]
88321-09-9
C17H30N2O5
Enzymes, Inhibitors, and Substrates
Enzyme Inhibitors by Enzyme
Enzyme Inhibitors
A to C
Calpain
BioChemical
Biochemicals and Reagents