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IVACHTIN

IVACHTIN Structure
CAS No.
745046-84-8
Chemical Name:
IVACHTIN
Synonyms
IVACHTIN;2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate;1H-Pyrrolo[3,4-c]quinoline-1,3(2H)-dione, 2-[2-(acetyloxy)ethyl]-4-methyl-8-(4-morpholinylsulfonyl)-;2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethylacetate;modest,reversibl,Inhibitor,noncompetitive,Caspase,caspases,nonpeptide,inhibit,apoptosis,Ivachtin,selectivity,staurosporininduced
CBNumber:
CB82459565
Molecular Formula:
C20H21N3O7S
Molecular Weight:
447.46
MOL File:
745046-84-8.mol
MSDS File:
SDS
Modify Date:
2023/9/4 15:51:00
Request For Quotation

IVACHTIN Properties

Boiling point 665.0±65.0 °C(Predicted)
Density 1.459±0.06 g/cm3(Predicted)
storage temp. Desiccate at +4°C
solubility Limited solubility, soluble in DMSO or DMF
pka 1.87±0.20(Predicted)
form Off-white solid

IVACHTIN Chemical Properties,Uses,Production

Uses

Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of caspase-3.

General Description

A cell-permeable, non-peptidyl pyrroloquinoline compound that acts as a potent, reversible, and non-competitive inhibitor of caspase-3 (IC50 = 23 nM) with larger than 10-fold greater selectivity towards caspase-3 than caspases-1, -2, and -4 through -10. Shown to display higher anti-apoptotic activity than Z-VAD-FMK (Cat. No. 627610) in preventing Staurosporine- (Cat. No. 569397) induced apoptosis in human Jurkat T cells.

Biochem/physiol Actions

Cell permeable: yes

IVACHTIN Preparation Products And Raw materials

Raw materials

Preparation Products

IVACHTIN Suppliers

Global( 54)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9707 58 Inquiry
BOC Sciences 1-631-485-4226; 16314854226 United States 14059 65 Inquiry
DC Chemicals 021-58447131 13564518121 China 9412 58 Inquiry
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 China 4551 58 Inquiry
Xianning Shen Lan Biomedical Research and Development Co., Ltd. 18171815831 China 2806 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9274 58 Inquiry
Olix (Shanghai) Pharmaceutical Technology Co., Ltd 17316404525 China 9650 58 Inquiry
Tocris Bioscience +44 (0) 117 916 3333 United Kingdom 5729 77 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Cayman Chemical Company 81
Shanghai EFE Biological Technology Co., Ltd. 58
BOC Sciences 65
DC Chemicals 58
Nantong QuanYi Biotechnology Co., Ltd 58
Xianning Shen Lan Biomedical Research and Development Co., Ltd. 58
RD International Technology Co., Limited 58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd 58
Tocris Bioscience 77

IVACHTIN Spectrum

IVACHTIN(745046-84-8)1HNMR

745046-84-8(IVACHTIN)Related Search:

4-METHYL-2,3-DIHYDRO-1H-PYRROLO[3,4-C]QUINOLINE-1,3-DIONE 2,4-DIMETHYLQUINOLINE-3-CARBOXAMIDE N-[2-(ACETOXY)ETHYL]-3-PYRIDINECARBOXAMIDE IVACHTIN
IVACHTIN 2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethylacetate 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate modest,reversibl,Inhibitor,noncompetitive,Caspase,caspases,nonpeptide,inhibit,apoptosis,Ivachtin,selectivity,staurosporininduced 1H-Pyrrolo[3,4-c]quinoline-1,3(2H)-dione, 2-[2-(acetyloxy)ethyl]-4-methyl-8-(4-morpholinylsulfonyl)- 745046-84-8 Inhibitor of caspase-3.