Pemetrexed Disodium Heptahydrate
- CAS No.
- 357166-29-1
- Chemical Name:
- Pemetrexed Disodium Heptahydrate
- Synonyms
- CS-248;Pemetrexed disodium(7HO);7-dihydro-4-oxo-3H-pyrrolo[2;PeMetrexed disodiuM 7-hydrate;Pemetrexed Disodium (1500659);Pemetrexed disodium hepthydrate;Pemetrexed (sodium salt hydrate);Pemetrexed for system suitability;Pemetrexed disodium 7 hydrate (CEP);Pemetrexed disodium heptahydrate CRS
- CBNumber:
- CB82509918
- Molecular Formula:
- C20H24N5NaO7
- Molecular Weight:
- 469.43
- MOL File:
- 357166-29-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/10/12 14:08:49
| storage temp. | 2-8°C |
|---|---|
| solubility | H2O: soluble30mg/mL, clear |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 31month. |
| InChI | InChI=1/C20H21N5O6.Na.H2O.H/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;1H2;/t13-;;;/s3 |
| InChIKey | AEZRDYKQLPDYEH-YTCXBBKHNA-N |
| SMILES | C(C1=CNC2NC(N)=NC(=O)C1=2)CC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1.[NaH].O |&1:20,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H341-H360FD-H372 | |||||||||
| Precautionary statements | P202-P260-P264-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
Pemetrexed Disodium Heptahydrate price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1490 | Pemetrexed disodium heptahydrate ≥98% (HPLC) | 357166-29-1 | 10MG | ₹11066.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1490 | Pemetrexed disodium heptahydrate ≥98% (HPLC) | 357166-29-1 | 50MG | ₹44610.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1596 | Pemetrexed Pharmaceutical Secondary Standard; Certified Reference Material | 357166-29-1 | 500MG | ₹9103.83 | 2022-06-14 | Buy |
Pemetrexed Disodium Heptahydrate Chemical Properties,Uses,Production
Description
Pemetrexed Disodium Heptahydrate(357166-29-1) is a multi-targeted antifolate with antitumor activity. Its formal name is N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki?= 109 nM), dihydrofolate reductase (Ki?= 7 nM), glycinamide ribonucleotide formyltransferase (Ki?= 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki?= 3.6 μM). It is a clinically useful anticancer agent. Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas. Activation of AMPK is associated with pemetrexed resistance. Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells.
General Description
Pemetrexed Disodium Heptahydrate secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pemetrexed is an anionic anticancer drug with a narrow therapeutic index. As a folate anti metabolite, it acts as an inhibitor of thymidylate synthase. It can act effectively against a broad-spectrum of solid tumors such as non-small-cell lung and breast cancers in clinical trials. It is also effective against both dihydrofolate reductase and glycinamide ribonucleotide formyl transferase.
Biochem/physiol Actions
Pemetrexed exhibits its activity against several tumors such as colorectal, breast, gastric, pancreatic, and cervical cancer. It acts as a substrate for multidrug resistance protein transporters.
in vitro
Pemetrexed (LY231514) disodium is a novel classical antifolate, the antitumor activity of which may result from simultaneous and multipie inhibition of several key folate-requiring enzymes via its polyglutamated metabolites. Pemetrexed (LY231514) is one of the best substrates that is known for the enzyme FPGS (Km=1.6 μM and Vmax/Km=621). It is likely that polyglutamation and the polyglutamated metabolites of LY231514 play profound roles in determining both the selectivity and the antitumor activity of this novel agent. Whereas LY23l5l4 only moderately inhibits TS (Ki=340 nM, recombinant mouse), the pentaglutamate of LY23l5l4 is 100-fold more potent (Ki=3.4 nM), making LY231514 one of the most potent folate-based TS inhibitors.
in vivo
The group of mice treated with PC61 plus Pemetrexed demonstrates statistically longer survival than other groups. In a survival analysis, significantly better survival is observed in the group of mice treated with PC61 plus Pemetrexed compare with those treated with PC61 alone, rat IgG plus Pemetrexed, or no treatment.
Pemetrexed Disodium Heptahydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| SGMR PHARMACEUTICALS PVT LTD | +91-9032001889 +91-9032001889 | Telangana, India | 83 | 58 | Inquiry |
| Zyphars Biopharmaceuticals Pvt. Ltd | +91-8007587007 +91-8007587007 | Mumbai, India | 14 | 58 | Inquiry |
| Basil Drugs AND Pharmaceuticals Pvt Ltd | +91-2249700250 +91-9619320820 | Mumbai, India | 108 | 58 | Inquiry |
| Gland Chemicals Pvt Ltd | +91-9492733833 +91-9346729196 | Telangana, India | 16 | 58 | Inquiry |
| Sakar Healthcare | +91-8976292690 +91-9967572302 | Gujarat, India | 47 | 58 | Inquiry |
| Beta Drugs | +91-9316590666 +91-7015991921 | Haryana, India | 34 | 58 | Inquiry |
| Mac Chem Products (India) Pvt Ltd (Naprod Group) | +91-9727753234 +91-7770016606 | Maharashtra, India | 37 | 58 | Inquiry |
| Surajlok Chemicals Pvt Ltd (Neon Laboratories Ltd) | +91-2268107000 +91-9987232509 | Maharashtra, India | 30 | 58 | Inquiry |
| Kekule Life Sciences Limited | +91-9963474090 +91-9963474090 | AndhraPradesh, India | 19 | 58 | Inquiry |
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