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2,4-Diamino-6-hydroxypyrimidine

2,4-Diamino-6-hydroxypyrimidine Structure
CAS No.
56-06-4
Chemical Name:
2,4-Diamino-6-hydroxypyrimidine
Synonyms
1956-6-4;2,6-DIAMINOPYRIMIDIN-4-OL;DAHP;2,6-Diaminopyrimidin-4(1H)-one;2,6-DIAMINO-4-PYRIMIDINOL;2,6-diamino-1H-pyrimidin-4-one;2,6-DIAMINO-4-HYDROXYPYRIMIDINE;4(3H)-pyrimidinone, 2,6-diamino-;9-60-9;NSC 9302
CBNumber:
CB0174912
Molecular Formula:
C4H6N4O
Molecular Weight:
126.12
MOL File:
56-06-4.mol
Modify Date:
2024/11/14 14:09:35

2,4-Diamino-6-hydroxypyrimidine Properties

Melting point 285-286 °C (dec.) (lit.)
Boiling point 234.22°C (rough estimate)
Density 1.3659 (rough estimate)
refractive index 1.7990 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Fine Crystalline Powder
pka 10.61±0.50(Predicted)
color White to cream
Sensitive Light Sensitive
Merck 14,2981
BRN 125006
InChIKey SWELIMKTDYHAOY-UHFFFAOYSA-N
CAS DataBase Reference 56-06-4(CAS DataBase Reference)
NIST Chemistry Reference 4(1H)-pyrimidinone, 2,6-diamino-(56-06-4)
EPA Substance Registry System 2,6-Diamino-4(1H)-pyrimidinone (56-06-4)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
Hazard Note  Irritant
TSCA  Yes
HS Code  29335995
NFPA 704
1
2 0

2,4-Diamino-6-hydroxypyrimidine price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ALFA India ALF-B21240-36 2,4-Diamino-6-hydroxypyrimidine, 96% 56-06-4 500g ₹18099 2022-05-26 Buy
ALFA India ALF-B21240-22 2,4-Diamino-6-hydroxypyrimidine, 96% 56-06-4 100g ₹4098 2022-05-26 Buy
ALFA India ALF-B21240-14 2,4-Diamino-6-hydroxypyrimidine, 96% 56-06-4 25g ₹1492 2022-05-26 Buy
TCI Chemicals (India) D1321 2,4-Diamino-6-hydroxypyrimidine 56-06-4 25G ₹7200 2022-05-26 Buy
Product number Packaging Price Buy
ALF-B21240-36 500g ₹18099 Buy
ALF-B21240-22 100g ₹4098 Buy
ALF-B21240-14 25g ₹1492 Buy
D1321 25G ₹7200 Buy

2,4-Diamino-6-hydroxypyrimidine Chemical Properties,Uses,Production

Description

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.

Chemical Properties

White Solid

Uses

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.[Cayman Chemical]

Purification Methods

It recrystallises from H2O. [Beilstein 25 III/IV 3642.]

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2,4-Diamino-6-hydroxypyrimidine,96% TIMTEC-BB SBB004252 2,4-DIAMINOPYRIMIDIN-6-OL 2,4-DIAMINO-6-HYDROXYPYRIMIDINE 2,4-DIAMINO-6-PYRIMIDINOL 2,4-DIAMINO-6(1H)-PYRIMIDINONE 2,6-DIAMINO-4-PYRIMIDINONE 2,6-DIAMINO-4(1H)-PYRIMIDINONE AURORA KA-376 AKOS MSC-0109 2,6-Diamino-4-Hydroxyprimidine 2-4-DIAMINO6HYDROXY PYRIMID 2,4- two-6- aMinohydroxy pyriMidine 2,4-DiaMino-6-hydroxypyriMidine 96% 2,4-DiaMino-6-hydroxypyriMidine, 97+% InChI=1/C4H6N4O/c5-2-1-3(9)8-4(6)7-2/h1H,(H5,5,6,7,8,9 2,4-Diamino-6-hydroxypyrimidiine 4(1H)-Pyrimidinone, 2,6-diamino- (8CI,9CI) 2,6-Diaminopyrimidin-4-one 6-Aminoisocytosine NSC 44914 NSC 680818 NSC 9302 2,4-Diamino-6-hydroxy 2,4-diaminohypoxanthine 2,6-Diamino-1H-pyrimidin-4-on 2,4-Diamino-6. -Hydroxypyimidine 2,6-DIAMINO-3H-PYRIMIDIN-4-ONE 4(1H)-Pyrimidinone, 2,6-diamino 2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol, 2,6-Diamino-4-pyrimidinone 2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol 2,4-Diamino-6-pyrimidinone 2,6-Diamino-3,4-dihydropyrimidine-4-one 2,6-Diamino-4(3H)-pyrimidinone 2,4-Diamino-6-hydroxypyrimidine,2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol, 2,6-Diamino-4-pyrimidinone 4-DiaMino-6-hydroxypyriMidine 2,4-DIAMINO-6-HYDROXYPYRIDIMIDINE 6-Hydroxy-2,4-diaminopyrimidine 2,4-Diamino-6-hydroxypyrimidine > 2,4-Diamino-6-hydroxypyrimidine ISO 9001:2015 REACH 2,4-Diamino-6-hydroxypyrimidine,56-06-4 NSC 18522 NSC18522 NSC-18522 3-methylidene-1,5-benzodioxepine Pemetrexed Impurity 16 2,6-DIAMINOPYRIMIDIN-4-OL DAHP 2,6-diamino-1H-pyrimidin-4-one 4(3H)-pyrimidinone, 2,6-diamino- 2,6-Diaminopyrimidin-4(1H)-one 1956-6-4 Minoxidil Impurity 19 2,6-DIAMINO-4-PYRIMIDINOL 2,6-DIAMINO-4-HYDROXYPYRIMIDINE 2,4-Diamino-6-hydroxypyrimidine(98.60%) 9-60-9 2.4-Diamino-6-pyrimidone