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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyrimidines >Dihydroxypyrimidine >2,4-Diamino-6-hydroxypyrimidine

2,4-Diamino-6-hydroxypyrimidine

2,4-Diamino-6-hydroxypyrimidine Structure
CAS No.
56-06-4
Chemical Name:
2,4-Diamino-6-hydroxypyrimidine
Synonyms
1956-6-4;2,6-DIAMINOPYRIMIDIN-4-OL;DAHP;2,6-Diaminopyrimidin-4(1H)-one;2,6-DIAMINO-4-PYRIMIDINOL;2,6-diamino-1H-pyrimidin-4-one;2,6-DIAMINO-4-HYDROXYPYRIMIDINE;4(3H)-pyrimidinone, 2,6-diamino-;9-60-9;NSC 9302
CBNumber:
CB0174912
Molecular Formula:
C4H6N4O
Molecular Weight:
126.12
MOL File:
56-06-4.mol
Modify Date:
2025/3/31 20:14:24
Request For Quotation

2,4-Diamino-6-hydroxypyrimidine Properties

Melting point 285-286 °C (dec.) (lit.)
Boiling point 234.22°C (rough estimate)
Density 1.3659 (rough estimate)
refractive index 1.7990 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka 10.61±0.50(Predicted)
form Fine Crystalline Powder
color White to cream
Sensitive Light Sensitive
Merck 14,2981
BRN 125006
InChIKey SWELIMKTDYHAOY-UHFFFAOYSA-N
CAS DataBase Reference 56-06-4(CAS DataBase Reference)
NIST Chemistry Reference 4(1H)-pyrimidinone, 2,6-diamino-(56-06-4)
EPA Substance Registry System 2,6-Diamino-4(1H)-pyrimidinone (56-06-4)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
Hazard Note  Irritant
TSCA  Yes
HS Code  29335995
NFPA 704
1
2 0

2,4-Diamino-6-hydroxypyrimidine price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ALFA India ALF-B21240-36 2,4-Diamino-6-hydroxypyrimidine, 96% 56-06-4 500g ₹18099 2022-05-26 Buy
ALFA India ALF-B21240-22 2,4-Diamino-6-hydroxypyrimidine, 96% 56-06-4 100g ₹4098 2022-05-26 Buy
ALFA India ALF-B21240-14 2,4-Diamino-6-hydroxypyrimidine, 96% 56-06-4 25g ₹1492 2022-05-26 Buy
TCI Chemicals (India) D1321 2,4-Diamino-6-hydroxypyrimidine 56-06-4 25G ₹7200 2022-05-26 Buy
Product number Packaging Price Buy
ALF-B21240-36 500g ₹18099 Buy
ALF-B21240-22 100g ₹4098 Buy
ALF-B21240-14 25g ₹1492 Buy
D1321 25G ₹7200 Buy

2,4-Diamino-6-hydroxypyrimidine Chemical Properties,Uses,Production

Description

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.

Chemical Properties

White Solid

Uses

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.[Cayman Chemical]

Synthesis

A solution of sodium ethoxide is prepared from 23 g. (1 g. atom) of sodium and 250 ml of anhydrous ethanol in a 1-l round-bottomed flask fitted with a reflux condenser carrying a calcium chloride drying tube. After the sodium has dissolved, the solution is cooled and 113 g. (1 mole) of ethyl cyanoacetate is added. This mixture is allowed to stand while a second solution of sodium ethoxide of the same volume and concentration is prepared. To this solution is added 97 g. (1.02 moles) of guanidine hydrochloride. The sodium chloride is separated by filtration, and the clear filtrate containing guanidine is added to the solution of ethyl sodiocyanoacetate. This mixture is heated for 2 hours under reflux and is then evaporated to dryness at atmospheric pressure. The solid product is dissolved in 325 ml. of boiling water and acidified with 67 ml. of glacial acetic acid. Upon cooling of the solution, 101–103 g. (80–82%) of yellow needles separates; m.p. 260–270° (dec.) 2,4-Diamino-6-hydroxypyrimidine synthesis route

Purification Methods

2,4-Diamino-6-hydroxypyrimidine recrystallises from H2O. [Beilstein 25 III/IV 3642.]

2,4-Diamino-6-hydroxypyrimidine Preparation Products And Raw materials

Raw materials

Guanidine nitrate Methyl cyanoacetate 2,4-DIAMINO-6-HYDROXY-PYRIMIDINE-5-CARBALDEHYDE 2,4-DIAMINO-6-FLUOROPYRIMIDINE Guanidine hydrochloride

Preparation Products

2,4-DIAMINO-6-MERCAPTOPYRIMIDINE 2,6-DIAMINO-4-METHOXY PYRIMIDINE BENZYL PHENYL SULFIDE 2,4-Diamino-6-hydroxy-5-nitropyrimidine 2,4-DIAMINO-6-ETHOXYPYRIMIDINE
4-Pyrimidinol 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-3,7-dihydro-5-(1-methylethyl)-
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2,4-Diamino-6-hydroxypyrimidine Suppliers

Global( 548)Suppliers
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GLR Innovations +91 9891111994 New Delhi, India 4535 58 Inquiry
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Reliance Rasayan Pvt Ltd +91-9427160241 +91-9427160241 Gujarat, India 21 58 Inquiry
Supplier Advantage
GLR Innovations 58
SYNGREEN LIFESCIENCES PVT.LTD 58
Saflik Pharma 58
Louis Pharmaceuticals Pvt Ltd 58
Vardhaman P Golechha 58
Ganapa Liife Science 58
SVH BIOSCIENCES 58
NSR Laboratories Pvt. Ltd. 58
SNECOFRi Pvt Ltd 58
Reliance Rasayan Pvt Ltd 58

2,4-Diamino-6-hydroxypyrimidine Spectrum

2,4-Diamino-6-hydroxypyrimidine(56-06-4)MS2,4-Diamino-6-hydroxypyrimidine(56-06-4)1HNMR2,4-Diamino-6-hydroxypyrimidine(56-06-4)IR12,4-Diamino-6-hydroxypyrimidine(56-06-4)IR2

56-06-4(2,4-Diamino-6-hydroxypyrimidine)Related Search:

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2,4-Diamino-6-hydroxypyrimidine,96% TIMTEC-BB SBB004252 2,4-DIAMINOPYRIMIDIN-6-OL 2,4-DIAMINO-6-HYDROXYPYRIMIDINE 2,4-DIAMINO-6-PYRIMIDINOL 2,4-DIAMINO-6(1H)-PYRIMIDINONE 2,6-DIAMINO-4-PYRIMIDINONE 2,6-DIAMINO-4(1H)-PYRIMIDINONE AURORA KA-376 AKOS MSC-0109 2,6-Diamino-4-Hydroxyprimidine 2-4-DIAMINO6HYDROXY PYRIMID 2,4- two-6- aMinohydroxy pyriMidine 2,4-DiaMino-6-hydroxypyriMidine 96% 2,4-DiaMino-6-hydroxypyriMidine, 97+% InChI=1/C4H6N4O/c5-2-1-3(9)8-4(6)7-2/h1H,(H5,5,6,7,8,9 2,4-Diamino-6-hydroxypyrimidiine 4(1H)-Pyrimidinone, 2,6-diamino- (8CI,9CI) 2,6-Diaminopyrimidin-4-one 6-Aminoisocytosine NSC 44914 NSC 680818 NSC 9302 2,4-Diamino-6-hydroxy 2,4-diaminohypoxanthine 2,6-Diamino-1H-pyrimidin-4-on 2,4-Diamino-6. -Hydroxypyimidine 2,6-DIAMINO-3H-PYRIMIDIN-4-ONE 4(1H)-Pyrimidinone, 2,6-diamino 2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol, 2,6-Diamino-4-pyrimidinone 2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol 2,4-Diamino-6-pyrimidinone 2,6-Diamino-3,4-dihydropyrimidine-4-one 2,6-Diamino-4(3H)-pyrimidinone 2,4-Diamino-6-hydroxypyrimidine,2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol, 2,6-Diamino-4-pyrimidinone 4-DiaMino-6-hydroxypyriMidine 2,4-DIAMINO-6-HYDROXYPYRIDIMIDINE 6-Hydroxy-2,4-diaminopyrimidine 2,4-Diamino-6-hydroxypyrimidine > 2,4-Diamino-6-hydroxypyrimidine ISO 9001：2015 REACH 2,4-Diamino-6-hydroxypyrimidine,56-06-4 NSC 18522 NSC18522 NSC-18522 3-methylidene-1,5-benzodioxepine Pemetrexed Impurity 16 2,6-DIAMINOPYRIMIDIN-4-OL DAHP 2,6-diamino-1H-pyrimidin-4-one 4(3H)-pyrimidinone, 2,6-diamino- 2,6-Diaminopyrimidin-4(1H)-one 1956-6-4 Minoxidil Impurity 19 2,6-DIAMINO-4-PYRIMIDINOL 2,6-DIAMINO-4-HYDROXYPYRIMIDINE 2,4-Diamino-6-hydroxypyrimidine(98.60%) 9-60-9 2.4-Diamino-6-pyrimidone