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ChemicalBook > Product Catalogue >Analytical Chemistry >Standard >Pharmaceutical Impurity Reference Standards >Pemetrexed Disodium Heptahydrate

Pemetrexed Disodium Heptahydrate

Pemetrexed Disodium Heptahydrate Structure
  • ₹9103.83 - ₹44610.9
  • Product name: Pemetrexed Disodium Heptahydrate
  • CAS: 357166-29-1
  • MF: C20H24N5NaO7
  • MW: 469.43
  • EINECS:639-569-0
  • MDL Number:MFCD09029394
  • Synonyms:N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate;Pemetrexed disodium hepthydrate;PeMetrexed disodiuM 7-hydrate;L-GlutaMic acid, N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-, disodiuM salt, heptahydrate;Pemetrexed for system suitability;Pemetrexed (sodium salt hydrate);N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hepthydrate;7-dihydro-4-oxo-3H-pyrrolo[2
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 500MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1596
  • Product descriptionPemetrexed Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging500MG
  • Price₹9103.83
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1490
  • Product descriptionPemetrexed disodium heptahydrate ≥98% (HPLC)
  • Packaging10MG
  • Price₹11066.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1490
  • Product descriptionPemetrexed disodium heptahydrate ≥98% (HPLC)
  • Packaging50MG
  • Price₹44610.9
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PHR1596 Pemetrexed Pharmaceutical Secondary Standard; Certified Reference Material 500MG ₹9103.83 2022-06-14 Buy
Sigma-Aldrich(India) SML1490 Pemetrexed disodium heptahydrate ≥98% (HPLC) 10MG ₹11066.7 2022-06-14 Buy
Sigma-Aldrich(India) SML1490 Pemetrexed disodium heptahydrate ≥98% (HPLC) 50MG ₹44610.9 2022-06-14 Buy

Properties

storage temp. :2-8°C
solubility :H2O: soluble30mg/mL, clear
form :powder
color :white to beige
Stability :Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 31month.
InChIKey :AEZRDYKQLPDYEH-YTCXBBKHNA-N
SMILES :C(C1=CNC2NC(N)=NC(=O)C1=2)CC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1.[NaH].O |&1:20,r|

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Pemetrexed is pyrrotopyrimidine-based, multi-targeted antifolate with broad in vivo antitumor activity. Originally identified as a highly efficient substrate for folylpolyglutamate synthase, pemetrexed potently inhibits multiple folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 μM). Its antiproliferative activity has been demonstrated in a wide variety of solid tumors, including non-small cell lung, breast, mesothelioma, colorectal, pancreatic, gastric, bladder, cervix, and head and neck.

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