IWR-1-endo
- CAS No.
- 1127442-82-3
- Chemical Name:
- IWR-1-endo
- Synonyms
- IWR-1;CS-624;CS-1858;IWR-1-endo;endo-IWR 1;IWR-1-endo, >=98%;IWR-1(IWR-1-endo);IWR-1-endo USP/EP/BP;Wnt Antagonist I, IWR-1-endo;IWR-1-endo - IWR-1 | endo-IWR-1
- CBNumber:
- CB82518787
- Molecular Formula:
- C25H19N3O3
- Molecular Weight:
- 409.44
- MOL File:
- 1127442-82-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| alpha | -3.0～+3.0°(20℃/D)(c=0.1,CH3CN) |
|---|---|
| Boiling point | 643.9±55.0 °C(Predicted) |
| Density | 1.425±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: soluble5mg/mL, clear |
| pka | 11.88±0.43(Predicted) |
| form | Liquid |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| WGK Germany | 3 |
IWR-1-endo price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I0161 | IWR-1 ≥98% (HPLC) | 1127442-82-3 | 5MG | ₹10857.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I0161 | IWR-1 ≥98% (HPLC) | 1127442-82-3 | 25MG | ₹42098.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 5.04462 | InSolution Wnt Antagonist I, IWR-1-endo - CAS 1127442-82-3 - Calbiochem | 1127442-82-3 | 5MG | ₹12940 | 2022-06-14 | Buy |
IWR-1-endo Chemical Properties,Uses,Production
Uses
IWR-1-endo act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b). Such compounds may be used in the treatment of Wnt protein signaling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosi s.
General Description
A cell-permeable p-imidobenzamidoquinoline, endo-diastereomer that is shown to inhibit the activity of TNKS1/PARP5a and TNKS2/PARP5b in in vitro auto-PARsylation assays (IC50 = 131 and 56 nM, respectively) and effectively suppress Wnt-stimulated transcription activity in L-Wnt-STF-based reporter assays (IC50 = 180 nM), while exhibiting little activity against PARP1 or PARP2 (IC50 >18.75 μM). Although both IWR-1-endo and XAV939 (Tankyrase1/2 Inhibitor; >Cat. No. 575545) act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1-endo exerts its effect via interaction with Axin, while XAV939 binds TNKS directly.
Biochem/physiol Actions
Cell permeable: yes
IWR-1-endo Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9343 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29824 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24099 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
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