5-Fluoro-2-methylaniline
- CAS No.
- 367-29-3
- Chemical Name:
- 5-Fluoro-2-methylaniline
- Synonyms
- 2-AMINO-4-FLUOROTOLUENE;2-METHYL-5-FLUOROANILINE;2-Amino-4-fluorotoluene~5-Fluoro-o-toluidine;TIMTEC-BB SBB004266;5-Fluoro-2-toluidine;5-Fluoro-2-methylani;Fluoromethylaniline7;5-FLUORO-O-TOLUIDINE;4-Fluoro-2-Aminotoluene;5-FLUORO-2-METHYLANILINE
- CBNumber:
- CB8263018
- Molecular Formula:
- C7H8FN
- Molecular Weight:
- 125.14
- MOL File:
- 367-29-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/18 21:58:05
| Melting point | 38-40 °C (lit.) |
|---|---|
| Boiling point | 98-100°C 15mm |
| Density | 1.13 g/cm3 (20℃) |
| refractive index | 1.538 |
| Flash point | 194 °F |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| form | Crystalline Solid or Liquid |
| pka | 3.44±0.10(Predicted) |
| color | Purple to brown |
| Water Solubility | insoluble |
| BRN | 2637584 |
| InChI | InChI=1S/C7H8FN/c1-5-2-3-6(8)4-7(5)9/h2-4H,9H2,1H3 |
| InChIKey | JLCDTNNLXUMYFQ-UHFFFAOYSA-N |
| SMILES | C1(N)=CC(F)=CC=C1C |
| CAS DataBase Reference | 367-29-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 5-Fluoro-2-methylaniline(367-29-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335-H302-H311-H332-H373 | |||||||||
| Precautionary statements | P261-P280-P301+P312+P330-P305+P351+P338-P260-P304+P340-P405-P501a-P264-P270-P271-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501 | |||||||||
| Hazard Codes | Xn,T,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38-23/24/25 | |||||||||
| Safety Statements | 26-27-36/37/39-45-36 | |||||||||
| RIDADR | UN 1325 4.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Toxic/Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214300 | |||||||||
| NFPA 704 |
|
5-Fluoro-2-methylaniline price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | F10402 | 5-Fluoro-2-methylaniline 99% | 367-29-3 | 10G | ₹3041.83 | 2022-06-14 | Buy |
| ALFA India | ALF-B25381-18 | 5-Fluoro-2-methylaniline, 98% | 367-29-3 | 50g | ₹13849 | 2022-05-26 | Buy |
| ALFA India | ALF-B25381-09 | 5-Fluoro-2-methylaniline, 98% | 367-29-3 | 10g | ₹3817 | 2022-05-26 | Buy |
| TCI Chemicals (India) | F0232 | 5-Fluoro-2-methylaniline min. 98.0 % | 367-29-3 | 5G | ₹2100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | F0232 | 5-Fluoro-2-methylaniline min. 98.0 % | 367-29-3 | 25G | ₹6500 | 2022-05-26 | Buy |
5-Fluoro-2-methylaniline Chemical Properties,Uses,Production
Chemical Properties
purple to brown crystalline solid
Uses
Used as a pharmaceutical intermediate in organic synthesis.
Synthesis
In a nitrogen-fed glovebox, Pd(P(o-tol)3)2 and CyPF-PtBu (1:1 ratio) were dissolved in dioxane and mixed for 5 min. A 20 mL scintation vial was charged with aryl halide (0.60 mmol, 1 equiv), ammonium sulfate (0.90 mmol, 1.5 equiv), and sodium tert-butoxide (2.7 mmol, 4.5 equiv). To this vial was added 6 mL of anhydrous dioxane and the appropriate amount of catalyst from the stock solution. The reaction vial was sealed with a Teflon-lined screw cap and removed from the glovebox. The reaction was stirred at the desired temperature for 12 h. The reaction mixture was diluted with EtOAc and filtered through a pad of Celite. The filtrate was concentrated in vacuo, and the crude product was purified by flash column chromatography. 5-Fluoro-2-methylaniline (Table 3, 2s) (CAS: 367-29-3) The reaction to form this product was conducted with 0.5 mol % Pd(P(o-tol)3)2 and 0.5 mol % CyPF-PtBu for 8 h. The crude product was isolated by flash column chromatography (5:1 Hexanes:EtOAc). 5-Fluoro-2-methylaniline was isolated as an oil in 76% yield. 1(600 MHz, CDCl3): δ 6.97 (t, J= 7.2 Hz, 1H), 6.40 (t, J= 9.9 Hz, 2H), 3.69 (s, 2H), 2.12 (s, 3H). 13C-NMR(151 MHz, CDCl3): δ 162.24 (d, JC-F= 240.9 Hz), 145.82 (d, JC-F= 10.6 Hz), 131.12 (d, JC-F= 9.6 Hz), 117.62 (d, JC-F = 2.6 Hz), 104.67 (d, JC-F= 21.0 Hz), 101.56 (d, JC-F= 24.6 Hz), 16.62 (s).
5-Fluoro-2-methylaniline Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
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| VASIN BIO LIFE SCIENCES PVT LTD | 9491644688 | Hyderabad, India | 2096 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| REDDY N REDDY PHARMACEUTICALS | 58 |
| Vyas Bio Life Sciences Pvt. Ltd | 58 |
| Oceanic Pharmachem Pvt. Ltd. | 58 |
| ALTAIR ALCHEMY Laboratories | 58 |
| A.J Chemicals | 58 |
| CHEMSWORTH | 30 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| VASIN BIO LIFE SCIENCES PVT LTD | 58 |