1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE

CAS No.: 168986-61-6

Chemical Name:: 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE

Synonyms: RS 67506;RS67506HCl;RS 67506 HYDROCHLORIDE;N-[2-[4-[3-(4-amino-5-chloro-2-methoxyphenyl)-3-oxopropyl]piperidin-1-yl]ethyl]methanesulfonamide;1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(1-2-methylsulfonylamino)ethyl-4-piperidinyl)-1-propanonehydrochloride;N-(2-(4-(3-(4-Amino-5-chloro-2-methoxyphenyl)-3-oxopropyl)piperidin-1-yl)ethyl)methanesulfonamide hydrochloride;1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride;1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE

CBNumber:: CB8335375

Molecular Formula:: C18H29Cl2N3O4S

Molecular Weight:: 454.41

MOL File:: 168986-61-6.mol

Modify Date:: 2023/5/18 11:31:11

Request For Quotation

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Properties

storage temp.	Store at RT
solubility	Soluble to 80 mM in H2O
form	Powder
Water Solubility	Soluble to 80 mM in water

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

RS 67506 Hydrochloride is a novel and potent 5-HT4 receptor agonist.

Definition

ChEBI: A hydrochloride salt obtained by mixing equimolar amounts of RS 39604 with hydrochloric acid. A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and alpha1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.

Biological Activity

A potent and selective 5-HT 4 partial agonist, with a pK i of 8.8 at 5-HT 4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT 1A, 1D, 2A, 2C , D 1 , D 2 and M 1-3 . It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Suppliers

Global( 16)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Service Chemical Inc.	888-895-6920	Germany	6373	71	Inquiry
3B Scientific Corporation	847.281.9822	United States	6744	47	Inquiry
MOLEKULA Ltd.	+44 (0) 1747 831066	United Kingdom	6152	66	Inquiry
CARBONE SCIENTIFIC CO.,LTD	+44(0)870 486 8629	United Kingdom	6682	30	Inquiry
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	China	15848	69	Inquiry
Tocris Bioscience	+44 (0) 117 916 3333	United Kingdom	5729	77	Inquiry
ApexBio Technology	+ 1-832-696-8203	United States	6254	58	Inquiry
Beijing Taize Ruida Technology Co., Ltd.	400-800-8151 13651185998	CHINA	6536	58	Inquiry
Beijing Bolide Biotechnology Co., Ltd.	010-51653916	CHINA	6172	58	Inquiry
Shanghai Weiwei Biological Technology Co., Ltd.	021-55669583 18616258598	CHINA	4398	58	Inquiry

Supplier	Advantage
Service Chemical Inc.	71
3B Scientific Corporation	47
MOLEKULA Ltd.	66
CARBONE SCIENTIFIC CO.,LTD	30
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Tocris Bioscience	77
ApexBio Technology	58
Beijing Taize Ruida Technology Co., Ltd.	58
Beijing Bolide Biotechnology Co., Ltd.	58
Shanghai Weiwei Biological Technology Co., Ltd.	58

168986-61-6(1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE)Related Search:

4-aminohexanoylphenone 1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE 1-[4-AMINO-5-CHLORO-2-(3,5-DIMETHOXYPHENYL)METHYLOXY]-3-[[1-[2-METHYLSULPHONYLAMINO]ETHYL]PIPERIDIN-4-YL]PROPAN-1-ONE HYDROCHLORIDE 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE 2-Chloro-5-methoxyaniline

1-(4-Amino-2-hydroxy-phenyl)-propan-1-one 1-(4-AMINO-3-CHLORO-PHENYL)-PROPAN-1-ONE P-HEXYLANILINE HYDROCHLORIDE 4-(3-PHENYL-PROPYL)-PIPERIDINE HCL

chevron_left

1of2

chevron_right

RS 67506 HYDROCHLORIDE 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(1-2-methylsulfonylamino)ethyl-4-piperidinyl)-1-propanonehydrochloride RS67506HCl RS 67506 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride N-[2-[4-[3-(4-amino-5-chloro-2-methoxyphenyl)-3-oxopropyl]piperidin-1-yl]ethyl]methanesulfonamide N-(2-(4-(3-(4-Amino-5-chloro-2-methoxyphenyl)-3-oxopropyl)piperidin-1-yl)ethyl)methanesulfonamide hydrochloride 168986-61-6 C18H28ClN3O4SHCl C18H29Cl2N3O4S