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CHROMOMYCIN A3

CAS No.: 7059-24-7

Chemical Name:: CHROMOMYCIN A3

Synonyms: TOYOMYCIN;nsc-58514;Chromomycin;aburamycinb;Olivomycin D;CHROMOMYCIN A3;Chromoycin A3;antibioticb599;ABURAMYCIN BETA;nosyl)-7-methyl-

CBNumber:: CB8356277

Molecular Formula:: C57H82O26

Molecular Weight:: 1183.25

MOL File:: 7059-24-7.mol

MSDS File:: SDS

Modify Date:: 2024/5/10 17:26:08

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CHROMOMYCIN A3 Properties

Melting point	185℃
alpha	D23 -57° (ethanol)
Boiling point	780.13°C (rough estimate)
Density	1.1451 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	2-8°C
solubility	Soluble in ethanol, DMSO, and ethyl acetate (10 mg/ml).
form	Yellow solid
pka	4.54±0.60(Predicted)
color	Yellow
Merck	13,2258
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H300

Precautionary statements

P264-P270-P301+P310-P405-P501

Hazard Codes

T+,T

Risk Statements

61-28

Safety Statements

53-28-36/37/39-45

RIDADR

UN 3462 6.1/PG 1

WGK Germany

RTECS

GB7875000

3-8-10

HazardClass

6.1(a)

PackingGroup

HS Code

29419090

Toxicity

Excitation max: ~445 nm. Emission max: ~575 nm. Sol in ethanol, ethyl acetate, DMSO, methanol. LD50 in mice (mg/kg): 1.85 i.v. (Slavik, Carter).

NFPA 704

	0
4		0

CHROMOMYCIN A3 price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C2659	Chromomycin A3 from Streptomyces griseus ≥95% (HPLC)	7059-24-7	5MG	₹32702.33	2022-06-14	Buy
Sigma-Aldrich(India)	C2659	Chromomycin A3 from Streptomyces griseus ≥95% (HPLC)	7059-24-7	10MG	₹50379.55	2022-06-14	Buy

Product number	Packaging	Price	Buy
C2659	5MG	₹32702.33	Buy
C2659	10MG	₹50379.55	Buy

CHROMOMYCIN A3 Chemical Properties,Uses,Production

Description

Chromomycin A₃ is an anthraquinone antibiotic and antitumor agent isolated from S. griseus that is used as a fluorescent probe for DNA with excitation/emission spectra of 445/575 nm. Its DNA binding is specific to two or more contiguous GC base pairs, which makes it suitable for characterizing heterochromatin in plants with species-specific AT:GC ratios. Chromomycin A₃ is cytotoxic against non-small cell lung cancer and cervical cancer in vitro (IC₅₀s = 1, 42, 60, and 40 nM for HCC44, A549, ME180, and HeLa cells, respectively). It also inhibits oxidative stress- and DNA damage-induced neuronal injury by enhancing Sp1 and Sp3 transcription factor binding.

Chemical Properties

Yellow powder

Uses

Chromomycin A3 is the major component of the chromomycin complex of the aureolic acid class, isolated from several Streptomyces species, and first reported in 1960. Chromomycin A3 exhibits a broad biological profile as an antibacterial, antifungal and antitumour agent. It binds reversibly to GC-specific DNA ligand in the minor groove which inhibits transcription, DNA gyrase and topoisomerase II activity. The intense UV spectrum and strong fluorescence makes chromomycin a useful stain for DNA.

General Description

Chemical structure: aureolic acid

Purification Methods

Dissolve the antibiotic (10g) in EtOAc and add to a column of Silica Gel (Merck 0.05-0.2microns, 4x70cm) in EtOAc containing 1% oxalic acid. Elute with EtOAc+1% oxalic acid and check fractions by TLC. Pool fractions, wash with H2O thoroughly, dry and evaporate. Recrystallise the residue from EtOAc. The heptaacetate has m 214o, [] D -20o (c 1, EtOH). [Miyamoto et al. Tetrahedron 23 421 1967, Harada et al. J Am Chem Soc 91 5896 1969, Beilstein 17/5 V 673.]

CHROMOMYCIN A3 Preparation Products And Raw materials

Raw materials

Preparation Products

CHROMOMYCIN A3 Suppliers

Global( 105)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	China	3002	58	Inquiry
Hebei Shengyang Water Conservancy Engineering Co., Ltd.	+8615373025980	China	858	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21675	55	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	China	10297	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	China	34571	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	26114	58	Inquiry
BOC Sciences	16314854226; +16314854226	United States	19743	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Hebei Shengyang Water Conservancy Engineering Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Fuxin Pharmaceutical	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58
BOC Sciences	58

7059-24-7(CHROMOMYCIN A3)Related Search:

AburaMycin A, NSC 131187 6-Methoxy-2-naphthaldehyde 5-Hydroxy-4-octanone 2,3,6-TRIMETHYLNAPHTHALENE 6'-Methoxy-2'-propiononaphthone

ISOVALEROPHENONE Naphthalen-2-ethanol 6-Methoxy-2-heptanonaphthone CHROMOMYCIN A3 2,6-DIMETHYLNAPHTHALENE

5,6,7,8-TETRAHYDRO-1-NAPHTHOL 2-Acetyl-6-methoxynaphthalene 2,6-HEPTANEDIONE 1,6-Dihydroxynaphthalene 2,3-DIMETHYLNAPHTHALENE

6-Hydroxy-2-naphthaldehyde 2,7-DIMETHYLNAPHTHALENE (R)-(-)-4-PHENYL-2-BUTANOL

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chromomycina(sub3) nosyl)-7-methyl- nsc-58514 olivomycind,3b-o-(4-o-acetyl-2,6-dideoxy-3-c-methyl-alpha-l-arabinohexopyra TOYOMYCIN 3BETA-O-(4-O-ACETYL-2.6-DIDEOXY-3-C-METHYL-ALPHA-L-ARABINO HEXOPYRANOSYL)-7-METHYLOLIVOMYCIN D 3B-O-(4-O-ACETYL-2,6-DIDEOXY-3-C-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSYL)-7-METHYLOLIVOMYCIN D 3B-O-(4-O-ACETYL-2,6-DIDEXY-3-C-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSYL)-7-METHYLOLIVOMYCIN ABURAMYCIN BETA CHROMOMYCIN A3 CHROMOMYCIN A3 STREPTOMYCES GRISEUS 3D-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-7-methylolivomycin D CHROMOMYCIN A(3), FOR FLUORESCENCE CHROMOMYCIN A3 FROM STREPTOMYCESGRISEUS APPROX. 96 Chromomycin D-threo-2-Pentulose, 1-C-(2S,3S)-7-4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-.alpha.-D-lyxo-hexopyranosyl)-.beta.-D-lyxo-hexopyranosyloxy-3-O-4-O-acetyl-2,6-dideoxy-3-C-methyl-.alpha.-L-arabino-hexopyranosyl-(1?3)-O-2,6-dideoxy-.beta.-D-arabino-h chromomycin a3from streptomyces griseus 3'''-O-(4-O-Acetyl-3-C-methyl-2,6-dideoxy-α-L-arabino-hexopyranosyl)-7-methylolivomycin D Chromoycin A3 Olivomycin D AburaMycin, ToyoMycin, NSC 58514, B 599-III, SR1768E aburamycinb antibiotic69895a antibioticb599 Chromomycin A - CAS 7059-24-7 - Calbiochem [(2R,3S,4R,6S)-6-[[(6S,7S)-6-[(2S,4R,5R,6R)-4-[(2S,4R,5R,6R)-4-[(2S,4S,5S,6S)-5-acetyloxy-4-hydroxy-4,6-dimethyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-7-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-4,10-dihydroxy-3-methyl-5-oxo-7,8-dihydro-6H-anthracen-2-yl]oxy]-4-[(2R,4R,5R,6R)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy-2-methyloxan-3-yl] acetate D-threo-2-Pentulose, 1-C-[(2S,3S)-7-[[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-D-lyxo-hexopyranosyl)-β-D-lyxo-hexopyranosyl]oxy]-3-[[O-4-O-acetyl-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy... CHROMOMYCIN A3 USP/EP/BP 7059-24-7 C57H82O26 Antibiotics Antibiotics A to Z Antibiotics A-F BioChemical antibiotic