Vagistat
- CAS No.
- 65899-73-2
- Chemical Name:
- Vagistat
- Synonyms
- Trosyl;Trosyd;Zoniden;vagistat;UK-20349;Fungibacid;Vagistat 1;ioconazole;Gyno-Trosyd;TIOCONAZOLE
- CBNumber:
- CB8416704
- Molecular Formula:
- C16H13Cl3N2OS
- Molecular Weight:
- 387.71
- MOL File:
- 65899-73-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/8/29 14:17:32
| Melting point | 79-81oC |
|---|---|
| Boiling point | 534.5±50.0 °C(Predicted) |
| Density | 1.3115 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| RTECS | NI4480000 |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Very slightly soluble in water, very soluble in methylene chloride, freely soluble in alcohol. |
| pka | 6.66±0.12(Predicted) |
| form | powder |
| color | white to off-white |
| CAS DataBase Reference | 65899-73-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H361d-H410 | |||||||||
| Precautionary statements | P202-P273-P280-P301+P312-P302+P352-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2934990002 | |||||||||
| NFPA 704 |
|
Vagistat price More Price(2)
Vagistat Chemical Properties,Uses,Production
Description
Tioconazole is an antifungal agent, closely related to miconazole. Tioconazole is effective in the topical treatment of superficial fungal infections and appears to be more potent than miconazole against Candida and Trichophyton species.
Chemical Properties
White powder EINECS: 265-973-8
Uses
antithrombotic
Definition
ChEBI: A member of the class of imidazoles that comprises 2-(2,4-dichlorophenyl)ethylimidazole carrying an additional (2-chloro-3-thienyl)methoxy substituent at position 2.
Indications
Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. In addition, tioconazole is indicated for therapy of vulvovaginal mycoses caused by Candida species and Candida (Torulopsis) glabrata.
Antimicrobial activity
Tioconazole is a broad-spectrum imidazole antimycotic with activity against almost all species of pathogenic fungi.
Pharmacokinetics
Tioconazole is normally not absorbed after topical application to the skin [173]. On vaginal application of an ovulum containing 300 mg tioconazole, a serum concentration of 21 μg/mL was observed after 8 h.
Clinical Use
1-[2-[(2-chloro-3-thienyl)methoxy]2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole (Vagistat) is used for the treatment ofvulvovaginal candidiasis. A vaginal ointment containing6.5% of the free base is available. Tioconazole is more effectiveagainst Torulopsis glabrata than are other azoles.
Side effects
Local irritations such as itching, burning sensations, erythema, and dermatitis, and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.
Vagistat Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Flax Laboratories | +91-9867665132 +91-9867665132 | Maharashtra, India | 44 | 58 | Inquiry |
| Sekhment pharmaventures | +91-9030088669 +91-9030088669 | Mumbai, India | 105 | 58 | Inquiry |
| Gufic Group | +91-2267261000 +91-2267261000 | Maharashtra, India | 22 | 58 | Inquiry |
| Solara Active Pharma Sciences Ltd | +91-8046632100 +91-7075706520 | Bangalore, India | 65 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Optimus Pharma Pvt Ltd (Sekhmet Pharmaventures)) | +91-9100091731 +91-9573334999 | Telangana, India | 57 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| SOLARA ACTIVE PHARMA SCIENCES LTD | +91 44 4344 6700 | New Delhi, India | 89 | 58 | Inquiry |
| OPTIMUS DRUGS PRIVATE LIMITED | 040-33889898 | New Delhi, India | 11 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
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