5-Fluoro-2-methylpyridine
- CAS No.
- 31181-53-0
- Chemical Name:
- 5-Fluoro-2-methylpyridine
- Synonyms
- 5-FLUORO-2-PICOLINE;3-FLUORO-6-PICOLINE;3-FLUORO-6-METHYLPYRIDINE;5-FLUORO-2-METHYLPYRIDINE;2-methyl-5-fluoro-pyridine;Pyridine, 5-fluoro-2-methyl-;5-Fluoro-2-methylpyridine 98+%;5-Fluoro-2-methylpyridine, 97%;5-FLUORO-2-PICOLINE5-FLUORO-2-METHYLPYRIDINE;5-Fluoro-2-methylpyridine ISO 9001：2015 REACH
- CBNumber:
- CB8479536
- Molecular Formula:
- C6H6FN
- Molecular Weight:
- 111.12
- MOL File:
- 31181-53-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/4/23 13:52:06
| Boiling point | 135-136 C |
|---|---|
| Density | 1.077g/ml |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | liquid |
| pka | 3.53±0.10(Predicted) |
| color | Clear, almost colourless |
| CAS DataBase Reference | 31181-53-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H227-H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | T,Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
5-Fluoro-2-methylpyridine Chemical Properties,Uses,Production
Synthesis
5-Amino-2-methyl pyridine (2.8 g, 25.9 mmol) was added to a mixture of water (15 mL) and cone. HCl (7 mL) and cooled to 0°C. NaNO2 (3.5 g, 51.8 mmol) was added portion-wise with stirring over 10 min whilst keeping the reaction temperature between -5℃ and O℃. After stirring for 10 min 60 % w/w HPF6 (14 mL) was added dropwise with cooling, at which point a precipitate formed. This was filtered, washed with cold water and diethyl ether and dried. The solid was then heated slowly to 100℃; the reaction being very exothermic. After 5 min a dark red oily material formed which was then cooled to r.t. The oil was basifed with dilute sodium hydroxide to pH ~10 and extracted with dichloromethane. The combined organics were dried over sodium sulfate, filtered and evaporated in vacuo. The residue was purified by column chromatography over neutral alumina using 20 % dichloromethane-petroleum ether to yield 5-fluoro-2- methyl pyridine (1.57 g, 55%) as an oil.
5-Fluoro-2-methylpyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1817 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| SL Drugs and Pharmaceuticals Pvt. Ltd. | +91 (40) 6661-1133 | New Delhi, India | 2683 | 50 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| Accela ChemBio Inc. | +1-858-6993322 | United States | 19825 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49732 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29808 | 58 | Inquiry |
| SIMAGCHEM CORP | +86-13806087780 | China | 17365 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34563 | 58 | Inquiry |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | China | 7906 | 58 | Inquiry |