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Histrelin

CAS No.: 76712-82-8

Chemical Name:: Histrelin

Synonyms: histrelin acetate;PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET;1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-;N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)-1-pyrrolidinyl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-[1-(phenylmethyl)-4-imidazoly;orf17070;Supprelin;RWJ-17070;HISTRELIN;Amyridine;Histreline Acetate

CBNumber:: CB8480046

Molecular Formula:: C66H86N18O12

Molecular Weight:: 1323.53

MOL File:: 76712-82-8.mol

Modify Date:: 2023/11/16 17:07:08

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Histrelin Properties

alpha	D20 -33.9° (c = 1 in acetic acid)
Density	1.46±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
form	powder
pka	9.82±0.15(Predicted)
Stability	Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H360
Precautionary statements	P201-P308+P313
Hazard Codes	T
Risk Statements	60
Safety Statements	53-22-36/37/39-45
WGK Germany	3
RTECS	OK6370800
HS Code	3504009000

Histrelin price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	L2761	[des-Gly10, D-His(Bzl)6]-LH-RH ethylamide ≥97% (HPLC), powder	76712-82-8	0.5MG	₹13985.9	2022-06-14	Buy
Sigma-Aldrich(India)	L2761	[des-Gly10, D-His(Bzl)6]-LH-RH ethylamide ≥97% (HPLC), powder	76712-82-8	1MG	₹23317.05	2022-06-14	Buy

Product number	Packaging	Price	Buy
L2761	0.5MG	₹13985.9	Buy
L2761	1MG	₹23317.05	Buy

Histrelin Chemical Properties,Uses,Production

Description

Histrelin, a synthetic gonadotrophin-releasing hormone (GnRH) agonist, was introduced as a first-line therapy for the treatment of central precocious puberty. When administered over a prolonged period, it suppresses the release of gonadotrophin, inhibits ovarian and testicular steroidogenesis, and prevents sexual maturation. Superior to the traditional therapy with progestational agents, histrelin appears to have decelerating effects on skeletal maturation allowing more statural growth and significantly increased final adult height. Histrelin has also been used to treat other disorders including endometriosis, polycystic ovarian disease, uterine leiomyomas, severe premenstrual syndrome and to prevent acute intermittent porphyria.

Uses

LHRH agonist.

Definition

ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, 1-benzyl-D-histidyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotro in-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the diacetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.

Histrelin Preparation Products And Raw materials

Raw materials

Preparation Products

Histrelin Suppliers

Global( 143)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	China	2345	58	Inquiry
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	China	616	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29901	58	Inquiry
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	China	10259	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Cellmano Biotech Limited	0551-65326643 18156095617	China	999	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	China	10297	58	Inquiry
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	China	12460	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Chengdu Youngshe Chemical Co., Ltd.	58
Nantong Guangyuan Chemicl Co,Ltd	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
Cellmano Biotech Limited	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
Hebei Mojin Biotechnology Co., Ltd	58

76712-82-8(Histrelin)Related Search:

Benzyl acetate Butyl acetate Cellulose acetate Ammonium acetate Magnesium acetate

Goserelin acetate Vinyl acetate Sodium acetate Taltirelin Alarelin Acetate

Ethyl acetate LHRH (1-6) AMIDE FERTIRELIN ACETATE Histamine

L-Prolinamide (D-LEU7)-HISTRELIN Fertirelin acetate

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Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt 5-oxo-L-pmlyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N^^-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-pmlinamide RWJ-17070 Supprelin 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-1-benzyl-D-His-L-Leu-L-Arg-L-Pro-N-ethyl-NH2 Histreline Acetate ((imbl)-d-his(sub6),pro(sub9)-net)lhrh (n-ethyl-l-prolinamide)-10-deglycinamide- 6-(1-(phenylmethyl)-d-histidine)-9-luteinizinghormonereleasingfactor(pig orf17070 PYR-HIS-TRP-SER-TYR-HIS(BZL)-LEU-ARG-PRO-NHET PGLU-HIS-TRP-SER-TYR-D-HIS[BZL]-LEU-ARG-PRO-NHET (HIS(BZL)6)-HISTRELIN HISTRELIN (DES-GLY10,HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LHRH (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE DES-GLY10,[D-HIS(BZL)6]-LH-RH ETHYLAMIDE (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LHRH [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LH-RH (HUMAN) (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN) Histrelin USP/EP/BP Histrelin Acetate(net) 1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)- PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET histrelin acetate N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)-1-pyrrolidinyl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-[1-(phenylmethyl)-4-imidazoly Amyridine 76712-82-8 C66H86N18O12 Biochemicals and Reagents Amino Acids and Peptides BioChemical Peptides Releasing Factors LH-RH hormones Peptide